Synergistic effects of multiple natural products in pancreatic cancer cells

Wang, Zhiwei; Desmoulin, Sita Kugel; Banerjee, Sanjeev; Kong, Dejuan; Li, Yiwei; Deraniyagala, Rohan; Abbruzzese, James L.; Sarkar, Fazlul H.

doi:10.1016/j.lfs.2008.06.017

Cited by 54 publications

(33 citation statements)

References 33 publications

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“…They also found that the effects of those compounds were associated with decreased Notch-1 expression and DNA binding activity of nuclear factor kappa B (NF-κB) and its target genes such as Cyclin D1, Bcl-2, and Bcl-xL [32]. …”

Section: Discussionmentioning

confidence: 99%

Effect of Turkish propolis extracts on proteome of prostate cancer cell line

et al. 2011

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BackgroundPropolis is a natural, resinous hive product that has several pharmacological activities. Its composition varies depending on the vegetation, climate, season and environmental conditions of the area from where it was collected. Surface enhanced laser desorption ionization time of flight mass spectrometry (SELDI-TOF MS) is a proteomic approach which has been used in cancer proteomics studies. Prostate cancer is one of the most commonly diagnosed cancers in men. It has shown that nutritional supplements rich in polyphenolic compounds such as propolis play a significant role in prostate cancer chemoprevention. The aim of this study is to evaluate if protein expression profile in PC-3 prostate cancer cell lines could be differentiated when incubated with dimethyl sulfoxide and water extracts of Turkish propolis.ResultsThe antioxidant potentials of dimethyl sulfoxide and water extracts of propolis were found in correlation with the amount of total phenolic compounds of them. Dimethyl sulfoxide and water extracts of propolis of 20 μg/mL reduced the cell viability to 24.5% and 17.7%, respectively. Statistically significant discriminatory peaks between control PC-3 cells and dimethyl sulfoxide extract of propolis-treated PC-3 cells were found to be the proteomic features at m/z 5143, 8703, 12661, 20184 and 32794, detected by CM10 ProteinChip, and the peak at m/z 3772, detected by Q10 ProteinChip. Between control PC-3 cells and water extract of propolis-treated PC-3 cells, statistically significant discriminatory peaks were found to be the proteomic features at m/z 15846, 16052 and 24658, detected by CM10 ProteinChip and the peaks at m/z 10348, 10899 and 11603, detected by Q10 ProteinChip.ConclusionsIt was concluded that dimethyl sulfoxide and water extracts of Turkish propolis may have anti-proliferative activity through differentiating protein expression profile in PC-3 prostate cancer cell lines along with their antioxidant capacity.

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Section: Discussionmentioning

confidence: 99%

Effect of Turkish propolis extracts on proteome of prostate cancer cell line

et al. 2011

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“…Curcumin in combination with carnosic acid displayed a strong synergism in inhibiting acute myeloid leukemia cells accompanied by enhanced activation of apoptotic pathways (Pesakhov et al 2010). Combination treatment of curcumin plus isoflavone synergistically inhibited cell growth of BxPC-3 pancreatic cancer cells (Wang et al 2008). Furthermore, the combination treatment produced stronger inhibition on Notch 1 and NF-κB-mediated pathways than that attained by either compound alone.…”

Section: Other Cancersmentioning

confidence: 99%

Diet-Based Strategies for Cancer Chemoprevention: The Role of Combination Regimens Using Dietary Bioactive Components

DiMarco-Crook

Xiao

2015

Annu. Rev. Food Sci. Technol.

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Chemopreventive agents that the general population can consume for prolonged periods of time with minimal risk of any side effects are of great interest to all in search of a solution to the pervasive incidence of cancer. Dietary bioactive components have been found to modulate many deregulated molecular pathways associated with the initiation and progression of different types of cancer. Combination regimens with dietary bioactive components are a promising strategy for cancer chemoprevention because they may offer enhanced protective effects against cancer development but cause little or no adverse effects. This article provides an overview of studies examining the combination of dietary bioactive components for the chemoprevention of major types of cancer. A better understanding of existing research on the combination of dietary bioactive components will provide an important basis for the rational design of future combination studies and the successful development of cancer chemoprevention strategies.

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“…Sufficient data from in vitro and in vivo experimental studies have produced solid evidence supporting the role of genistein as a potent anti-tumor agent by targeting multiple signaling pathways such as NF-κB, Wnt, Notch-1, and Akt/mTOR in many different types of cancers [193–199]. Accumulating evidence from multiple in vitro and in vivo studies has also indicated that genistein exerts an anti-oxidant activity by inhibition of ROS production, DNA oxidation, lipid peroxidation, and NF-κB-mediated inflammatory cytokines in various cells including cancer cells [200–207].…”

Section: Genistein a Soy Isoflavone As A Potent Anti-oxidant Agenmentioning

confidence: 99%

Targeting CSCs in Tumor Microenvironment: The Potential Role of ROS-Associated miRNAs in Tumor Aggressiveness

Bao¹,

Azmi²,

Li³

et al. 2013

CSCR

Self Cite

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Reactive oxygen species (ROS) have been widely considered as critical cellular signaling molecules involving in various biological processes such as cell growth, differentiation, proliferation, apoptosis, and angiogenesis. The homeostasis of ROS is critical to maintain normal biological processes. Increased production of ROS, namely oxidative stress, due to either endogenous or exogenous sources causes irreversible damage of bio-molecules such as DNA, proteins, lipids, and sugars, leading to genomic instability, genetic mutation, and altered gene expression, eventually contributing to tumorigenesis. A great amount of experimental studies in vitro and in vivo have produced solid evidence supporting that oxidative stress is strongly associated with increased tumor cell growth, treatment resistance, and metastasis, and all of which contribute to tumor aggressiveness. More recently, the data have indicated that altered production of ROS is also associated with cancer stem cells (CSCs), epithelial-to-mesenchymal transition (EMT), and hypoxia, the most common features or phenomena in tumorigenesis and tumor progression. However, the exact mechanism by which ROS is involved in the regulation of CSC and EMT characteristics as well as hypoxia- and, especially, HIF-mediated pathways is not well known. Emerging evidence suggests the role of miRNAs in tumorigenesis and progression of human tumors. Recently, the data have indicated that altered productions of ROS are associated with deregulated expression of miRNAs, suggesting their potential roles in the regulation of ROS production. Therefore, targeting ROS mediated through the deregulation of miRNAs by novel approaches or by naturally occurring anti-oxidant agents such as genistein could provide a new therapeutic approach for the prevention and/or treatment of human malignancies. In this article, we will discuss the potential role of miRNAs in the regulation of ROS production during tumorigenesis. Finally, we will discuss the role of genistein, as a potent anti-tumor agent in the regulation of ROS production during tumorigenesis and tumor development.

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Synergistic effects of multiple natural products in pancreatic cancer cells

Cited by 54 publications

References 33 publications

Effect of Turkish propolis extracts on proteome of prostate cancer cell line

Effect of Turkish propolis extracts on proteome of prostate cancer cell line

Diet-Based Strategies for Cancer Chemoprevention: The Role of Combination Regimens Using Dietary Bioactive Components

Targeting CSCs in Tumor Microenvironment: The Potential Role of ROS-Associated miRNAs in Tumor Aggressiveness

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