Synergistic effects of parabens and plastic nanoparticles on proliferation of human breast cancer cells

Roje, Željka; Ilić, Krunoslav; Galić, Emerik; Pavičić, Ivan; Turčić, Petra; Stanec, Zdenko; Vrček, Ivana Vinković

doi:10.2478/aiht-2019-70-3372

Cited by 27 publications

(18 citation statements)

References 11 publications

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“…Currently PBs are classified as endocrine disruptors, which have genotoxic and cytotoxic effects 15 , 16 and affect many internal organs and systems, mainly including the reproductive, immune and endocrine systems 17 – 20 . Some studies have also reported correlations between PBs and obesity, disorders in the nervous system developmental disorders and neoplastic processes 11 , 21 – 23 . Due to adverse effects of PBs, the legislation of many countries has introduced the limitation of these substances.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of human exposure to parabens in north eastern Poland through hair sample analysis

Wojtkiewicz

Tzatzarakis

Vakonaki

et al. 2021

Sci Rep

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Parabens (PBs) are a group of substances commonly used in industry. They also pollute the environment, penetrate into living organisms and adversely affect various internal organs. During this study, the degree of exposure of people living in Olsztyn, a city in north eastern Poland, to selected parabens most often used in industry was studied. The chemicals under investigation included: methyl paraben—MePB, ethyl paraben—EtPB, propyl paraben—PrPB, benzyl paraben BePB and butyl paraben -BuPB. To this aim, hair samples collected from the scalps of 30 volunteers were analyzed using a liquid chromatography–mass spectrometry technique. All PBs studied were present in a high percentage of analyzed samples (from 76.7% in the case of BePB to 100% in the case of MePB and PrPB). The mean concentration levels were 4425.3 pg/mg for MeBP, 704.0 pg/mg for EtPB, 825.7 pg/mg for PrPB, 135.2 pg/mg for BePB and 154.5 pg/mg for BuPB. Significant differences in PB concentration levels between particular persons were visible. On the other hand, gender, age and artificial hair coloring did not cause statistically significant differences in PB levels. Obtained results have clearly indicated that people living in north eastern Poland are exposed to various PBs, and therefore these substances may affect their health status. However, the evaluation of PBs influence on human health requires further research.

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Section: Introductionmentioning

confidence: 99%

Evaluation of human exposure to parabens in north eastern Poland through hair sample analysis

Wojtkiewicz

Tzatzarakis

Vakonaki

et al. 2021

Sci Rep

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“…Still because of their small size, nanoparticles can translocate and reach the systemic circulation to be potentially distributed to other organs. This explains why some studies investigated the damages to the cardio-vascular system (Asweto et al, 2017;Feng et al, 2018Feng et al, , 2017 and to other organs (Cotena et al, 2021;Courter et al, 2007;Deville et al, 2016;Ku et al, 2017;Lai et al, 2020;Roje et al, 2019;Schirinzi et al, 2017;Teng et al, 2020;Xia et al, 2011). Among the different organs, the digestive system is quite well studied (Ahamed et al, 2020a(Ahamed et al, , 2019bCao et al, 2021Cao et al, , 2019Dussert et al, 2020;Shi et al, 2010;Zheng et al, 2012).…”

Section: A Literature Review On the Joint Toxicity Of Nanoparticles And Co-contaminantsmentioning

confidence: 99%

“…In Table 2, the category other/ various includes studies on the nervous system (Ku et al, 2017;Schirinzi et al, 2017), immune system (Deville et al, 2016), kidney cells (Xia et al, 2011), breast cells (Roje et al, 2019), on carcinogenesis (Courter et al, 2007), reproductive organs (Cotena et al, 2021), fetus (Teng et al, 2020) or deal with global effects, affecting several organs (Courter et al, 2007;Lai et al, 2020;Teng et al, 2020).…”

Section: A Literature Review On the Joint Toxicity Of Nanoparticles And Co-contaminantsmentioning

confidence: 99%

“…This mechanism is referred to as the "Trojan horse" effect (Deng et al, 2017;Liu et al, 2018). This concept explaining the facilitated entry of toxic molecules adsorbed on nanoparticles and resulting in an enhanced intracellular concentration of pollutants was illustrated by numerous studies (Ahamed et al, 2019b;Dussert et al, 2020;Guo et al, 2013;Roje et al, 2019;Yu et al, 2015;Zheng et al, 2012). For instance, Yu et al…”

Section: A Carrier Effect Leading To Increased Toxicitymentioning

confidence: 99%

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Combined effects of nanoparticles and other environmental contaminants on human health - an issue often overlooked

Forest

2021

NanoImpact

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Air pollution is considered as a major public health issue worldwide. It consists of a complex mixture of pollutants including nanoparticles to which we are increasingly exposed to due to the dramatic development of the nanotechnologies and their incidental or intentional release in the environment. Consequently, some concerns have raised about the combined toxicity of air particulates and other air pollutants on human health. However, the interactions between the contaminants and their resulting combined toxicity are often overlooked. Indeed, the biological effects triggered by nanoparticles are usually assessed focusing on individual nanoparticles, while their interaction with co-contaminants can deeply impact, either positively or negatively, their biodistribution, fate in the organism and toxicological profile (additive, synergistic or antagonistic responses). This paper presents a bibliographic review on the combined toxicity of nanoparticles and co-pollutants and discusses the underlying mechanisms. It also highlights the scarcity of data in the current literature, arguing for an urgent need to take into account the mixture effects to be more representative of real-life conditions for a better and accurate human health risk assessment and management.

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“…The detection of parabens, specifically in human breast cancer tissue, moreover implied their potential to drive the sustained proliferation of breast epithelial cells that possess estrogen receptors (ER), specifically the estrogen receptor alpha (ERα). [ 5–8 ]…”

Section: Introductionmentioning

confidence: 99%

The potential implications of estrogenic and antioxidant‐dependent activities of high doses of methyl paraben on MCF7 breast cancer cells

El-Sehly

Mourad

Mehanna

et al. 2022

J Biochem & Molecular Tox

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Methyl paraben (MP) is an endocrine-disrupting compound that possesses estrogenic properties and contributes to an aberrant burden of estrogen signaling in the human breast and subsequently increasing the risks for the development of breast cancer. The exact exposure, as well as the safe concentrations, are variable among daily products. The present study addresses the effects of exposure to escalated concentrations of MP on the proliferation of MCF-7 breast cancer cells in addition to exploring its other mechanisms of action. The study involved exposure of cultured MCF-7 breast cancer cells to seven MP concentrations, ranging from 40 to 800 µM for 5 days. Cell viability, apoptosis, and proliferation were respectively assessed using crystal violet test, flow cytometric analysis, and quantitative real-time polymerase chain reaction for Ki-67 expression. The estradiol (E2) secretion and oxidative stress were also assessed and analyzed in correlation to MP's proliferation and cytotoxicity potentials. The results showed that the maximum proliferative concentration of MP was 800 µM. At a concentration of 40 μM and higher, MP induced increased expression of Ki-67, denoting enhanced proliferation of the cells in monolayer culture. A positive correlation between the detrimental oxidative stress effect of MP's tested concentrations, cell proliferation, and viability was demonstrated (p < 0.05). Our results indicated that MP at high doses induced sustained cell proliferation due to E2 secretion as well as its antioxidant activity. Accordingly, it was concluded that high and unpredicted exposure to MP might carry a carcinogenic hazard on estrogen receptor-positive breast cancer cells.

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Synergistic effects of parabens and plastic nanoparticles on proliferation of human breast cancer cells

Cited by 27 publications

References 11 publications

Evaluation of human exposure to parabens in north eastern Poland through hair sample analysis

Evaluation of human exposure to parabens in north eastern Poland through hair sample analysis

Combined effects of nanoparticles and other environmental contaminants on human health - an issue often overlooked

The potential implications of estrogenic and antioxidant‐dependent activities of high doses of methyl paraben on MCF7 breast cancer cells

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