Synergistic Effects of Photobiomodulation Therapy with Combined Wavelength on Diabetic Wound Healing <i>In Vitro</i> and <i>In Vivo</i>

Hamushan, Musha; Zhang, Yubo; Xu, Z. Y.; Ren, Zun; Du, Jiafei; Ju, Jiaqi; Peng, Chong; Tan, Moyan; Han, Pei

doi:10.1089/photob.2021.0068

Cited by 8 publications

(10 citation statements)

References 38 publications

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“…The contents were grouped into three categories to facilitate the presentation of the information extracted after reading and analyzing the recommendations: in vitro/mixed, pre-clinical, and clinical studies. Eight in vitro studies investigated the effects of BL exclusively in cell culture [ 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ], two articles included in vitro and in vivo experiments [ 64 , 65 ], and one used ex vivo methods [ 66 ]. Immortalized myofibroblasts, fibroblasts, keratinocytes, endothelial cells [ 56 , 57 , 59 , 61 , 62 , 63 , 66 ], and primary cultures of human fibroblasts and keratinocytes [ 58 , 60 ] were used.…”

Section: Resultsmentioning

confidence: 99%

“…The authors also used different wavelengths (nm) and energy densities (J/cm 2 ). The details for the studies are: 470 nm, 50 mW, and 30 J/cm 2 [ 57 ]; 470 nm, 30 mW/cm 2 , and 3, 5, 10, and 55 J/cm 2 [ 56 ]; 453 nm, 50 mW/cm 2 , and 2 and 30 J/cm 2 [ 58 ]; 475 nm, 40 mw, and 24 J/cm 2 [ 59 ]; 450 and 490 nm, 30 mW, and 30 J/cm 2 [ 60 ]; 453 nm, 30 mW/cm 2 , and 2 and 30 J/cm 2 [ 66 ]; 465 nm and 3 J/cm 2 , without a reported power density [ 64 ]; 450 nm, 75 mW/cm 2 , and 0.63 and 0.95 J/cm 2 [ 61 ]; 420 nm, 680 mW/cm 2 , and 3.43, 6.87, 13.7, 20.6, 30.9, and 41.2 J/cm 2 [ 63 ]; 460 nm, 4 mW/cm 2 , and 2.4 and 4.8 J/cm 2 [ 65 ]; and 400–450 nm, 120 mW/cm 2 , and 28.9 J/cm 2 [ 62 ].…”

Section: Resultsmentioning

confidence: 99%

“…Another variable considered important for adequate light delivery to the tissues is the irradiation time. Among the seven in vitro/mixed articles, the irradiation time ranged from 5 s to 20 min ( Table 2 ) [ 57 , 59 , 61 , 62 , 63 , 64 , 65 ]. Three studies did not report the irradiation time [ 58 , 60 , 66 ], and one study reported that the time was given by the equipment automatically [ 56 ].…”

Section: Resultsmentioning

confidence: 99%

“…Cai et al (2022) [ 65 ] demonstrated a higher concentration of NO in the combined BL/RL group compared with the control group ( p < 0.01). The NO concentration in the BL group was significantly higher than in the RL group ( p < 0.05).…”

Section: Resultsmentioning

confidence: 99%

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Photobiomodulation with Blue Light on Wound Healing: A Scoping Review

Prado

Zanchetta

Barbieri

et al. 2023

Life

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Background: Photobiomodulation consists of inducing healing by irradiating light. This scoping review investigates the effect of blue light on the healing process. Methods: The MEDLINE, Web of Science, Scopus, and CINAHL databases were searched. Two reviewers independently examined the search results and extracted data from the included studies. A descriptive analysis was performed. Results: Twenty-two articles were included. Studies were categorized as in vitro/mixed, preclinical, and clinical. The power density used was 10–680 mW/cm2 in most of the in vitro/preclinical studies, the irradiation time ranged from 5 s to 10 min, and different wavelengths and energy densities were used. In clinical studies, the wavelength ranged from 405 to 470 nm, and the energy density varied from 1.5 to 30 J/cm2. Conclusions: A low energy density (<20 J/cm2) was able to stimulate the different cell types and proteins involved in healing, while a high energy density, 20.6–50 J/cm2, significantly reduced cell proliferation, migration, and metabolism. There is a great variety of device parameters among studies, and this makes it difficult to conclude what the best technical specifications are. Thus, further studies should be performed in order to define the appropriate parameters of light to be used.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Photobiomodulation with Blue Light on Wound Healing: A Scoping Review

Prado

Zanchetta

Barbieri

et al. 2023

Life

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“…concluded that PBM with RLT plus BLT had a synergistic effect on skin injury repair and could be a more effective approach to skin ulcer repair in diabetic patients 37 (Table 3).…”

Section: Effect Of Blt On Wound Healing In Diabetic Animalsmentioning

confidence: 99%

Impact of Blue Light Therapy on Wound Healing in Preclinical and Clinical Subjects: A Systematic Review

Bayat

Albright²,

Hamblin

et al. 2022

J Lasers Med Sci

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Introduction: While a wound caused by a minor cutaneous incision routinely heals in a short time, wounds from major surgical operations might need numerous days to heal and may leave an obvious cicatrix. The use of blue light therapy (BLT) to destroy infectious microorganisms and disrupt biofilm formation could be an efficient method for healing ulcers. This systematic review focused on the effects of BLT in different preclinical in vivo studies and clinical models of skin wound healing. Furthermore, this study attempted to determine what main light parameters should be tested in preclinical and clinical studies. Methods: The online databases PubMed.gov, Google Scholar, Scopus, Web of Science, and Cochrane were searched using the keywords "blue light" and "wound healing" according to PRISMA guidelines. No publication time limit was enforced. Results: A total of 858 articles were identified, and 17 articles in three distinct categories were included for review. They comprised two articles on humans, fourteen articles on healthy animals, and one article on diabetic animals. Conclusion: Some studies have shown that the application of BLT on preclinical and clinical models of wound healing in vivo is able to significantly accelerate the healing process. Few studies, however, have explored the bactericidal effect of BLT on skin injury repair in burn patients. Further preclinical investigations designed to provide a better understanding of the bactericidal effect of BLT using standardized protocols, different BLT wavelengths, and different stages of the wound healing process of infected wounds and ulcers in healthy and diabetic animals should be carried out before clinical trials can be considered. BLT could eventually be a good option for treating infected chronic wounds, including those in diabetic patients.

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Effects of multiwavelength photobiomodulation for the treatment of traumatic soft tissue injuries associated with bone fractures: A double‐blind, randomized controlled clinical trial

Neto

Martimbianco

Mesquita‐Ferrari

et al. 2023

Journal of Biophotonics

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This study evaluated the efficacy and safety of multiwavelength photobiomodulation (MPBM) in healing soft tissue injuries associated with tibial and/or ankle fractures. Participants were randomized into the MPBM or control group. Primary outcome was wound healing, measured by the Bates‐Jensen scale. Assessments were performed daily. Twenty‐seven hospitalized adults were included. MPBM showed an improvement in the daily mean Bates‐Jensen scale (MPBM 32.1 vs. control 34.2; p = 0.029), daily mean pain score change (MPBM 0.5 vs. control 0.2; p = 0.04) and occurrence of infection at the site of the external fixator pins (MPBM 15.3% vs. control 57.1%; p = 0.02). MPBM group also showed faster‐wound resolution (MPBM 13.1 vs. control 23.1 days). Subgroup analysis showed improvement in the MPBM group among less severe patients on the Bates‐Jensen scale (MPBM 27.4 vs. control 34.7; p = 0.0081) and mean time for wound resolution (MPBM 7.0 vs. control 14.6 days; p = 0.03). MPBM appears safe and effective in reducing wound resolution time, infection in the surgical pin sites, reported pain and time before definitive surgery.

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Synergistic Effects of Photobiomodulation Therapy with Combined Wavelength on Diabetic Wound Healing In Vitro and In Vivo

Cited by 8 publications

References 38 publications

Photobiomodulation with Blue Light on Wound Healing: A Scoping Review

Photobiomodulation with Blue Light on Wound Healing: A Scoping Review

Impact of Blue Light Therapy on Wound Healing in Preclinical and Clinical Subjects: A Systematic Review

Effects of multiwavelength photobiomodulation for the treatment of traumatic soft tissue injuries associated with bone fractures: A double‐blind, randomized controlled clinical trial

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