Synergistic Effects of Propolis Combined with 2-Phenoxyethanol and Antipyretics on the Growth of Staphylococcus aureus

Grecka, Katarzyna; Szweda, Piotr

doi:10.3390/pharmaceutics13020215

Cited by 10 publications

(3 citation statements)

References 60 publications

(61 reference statements)

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“…Presence of phenolic compounds and flavonoides are recognized for antimicrobial activity of propolis [112], Furthermore, phenylates flavonoids, is responsible for cell membrane damage, caused by lipophilic prenyl group. Synergistic activity between phenolic and other compounds was reported previously, by Castaldo [113] and recently, by Grecka [114]. Substances identified in propolis, such as pinocembrin, galangin, caffeic acid, ferulic acid, pinobanksin, benzyl ester, may act on the microbial membrane or cell wall site, causing functional and structural damages [19,105], constituents of propolis can interact with bacterial stucture by forming intramolecular hydrogen bonds that create hydrophobic interactions between the cell wall or membrane and propolis antimicrobial compounds [108].…”

Section: Antibacterial Activitysupporting

confidence: 60%

Biological Activity of Propolis: An Update

Benhanifia¹,

SOLTANI²

2022

Preprint

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Antibiotic resistance was described soon discovery of penicillin by Fleming. In recent years, there has been increasing research interest in the development of alternatives to address this problem. Natural products, mainly, have long been considered as sources of drugs, and a great part of pharmaceuticals available in modern medicine are directly or indirectly derived from natural sources. propolis been used to treat human diseases since ancient times, propolis, is a natural resinous mixture produced by honeybees (Apis mellifera) from collected parts of plants, he is increasingly recognized by their wide range of biological and pharmacological properties, As anti- infective agent, combination synergy with standard antibiotics could be very promising alternative strategy

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Section: Antibacterial Activitysupporting

confidence: 60%

Biological Activity of Propolis: An Update

Benhanifia¹,

SOLTANI²

2022

Preprint

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“…Además, existen otras líneas de investigación que trabajan con otro compuesto natural, el própolis, el cual se ha observado que interfiere en la actividad antimicrobiana de algunos antisépticos, aumentándola en el caso de administrarse junto a dihidrocloruro de octenidina (tensioactivo catiónico) o 2-fenoxietanol y disminuyéndola en el caso de la clorhexidina. Estos estudios se encuentran en fase de desarrollo con previsiones a futuras optimizaciones para su uso en la clínica (76) .…”

Section: Poliuretanosunclassified

Avances en las formulaciones de los antisépticos

González-Rodrı́guez

Calle-Moriel

2021

Ars Pharm

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Objetivo: Revisar nuevas formulaciones antisépticas que minimicen los inconvenientes de las formulaciones convencionales y mejoren la efectividad los tratamientos actualmente usados. Metodología: Se ha realizado una búsqueda bibliográfica en diferentes bases de datos científicas, como Pubmed o Sciencedirect, entre otras, así como en artículos de revistas científicas, libros, tesis doctorales y páginas webs oficiales siguiendo siempre criterios de inclusión y exclusión previamente establecidos. Una vez seleccionados los artículos de interés mediante palabras clave, se procedió a la organización de los contenidos de la revisión. Resultados: Las formulaciones convencionales usadas en antisepsia presentan algunas limitaciones, como la formación de biopelículas por Staphylococcus aureus resistentes a meticilina (MRSA), la necesidad de conseguir un efecto más prolongado en el tiempo y la potenciación de la actividad microbiana debido a la resistencia a antisépticos, entre otros. Por este motivo, existen diversas líneas de investigación que intentan contrarrestar estas barreras mediante el diseño de nuevas formulaciones, como los sistemas de administración autoemulsionables de fármacos (SEDDS), sistemas formadores de película o usando la nanotecnología en forma de micelas cargadas con antisépticos, nanopartículas de organosílica mesoporosa o como nanopartículas de plata u ZnO que se combinan con polímeros como los hidrogeles o los poliuretanos para conseguir tratamientos más eficaces mejorando sus propiedades tanto antisépticas como mecánicas. Conclusiones: Las diferentes estrategias que se abordan en esta revisión presentan mejores propiedades antisépticas que las terapias convencionales, según se recoge en los artículos revisados. Por este motivo, seguramente formarán parte de la amplia gama de antisépticos en un futuro próximo.

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“…Propolis has a vast number of Chemical Compounds, many of the researchers claimed to have 350 to 500 Chemical Constituents in "Bee Propolis" 3,6,7 . a lot of chemical constituents make Propolis an important topic of research, and the main chemical compounds found in different samples of "Bee Propolis" are: - Galangin 3,6,7,13  Pinocembrin 3,6,7,11,13  Pinobanksin 1,3,13,16  Quercetin 3,10,11,13,14  Apigenin 1,3,11,13  Caffeic Acid 3,14 So, in the formulation development. The Propolis is used as a natural polymer, and HPMC K 200 M is used as a synthetic polymer, and the excipients, such as Lactose, PVP K30, Talc, and Magnesium Stearate are used.…”

mentioning

confidence: 99%

Untitled

2022

IJPSR

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Ibuprofen is a Non-steroidal anti-inflammatory (NSAID) class drug and is used to treat pain, minor aches, fever, inflammation, and arthritis. Ibuprofen has an oral dose of 300 mg minimum and 3200 mg maximum in a day and is the main reason for the increase in its dosing frequency; many of the Ibuprofen formulations are of three times a day dosing and is the main reason for the development of such a formulation which can reduce the dosing frequency, so many researchers developed Ibuprofen matrix dosage form which can give a prolonged therapeutic effect. But in this formulation, Ibuprofen is combined with a Natural, Resinous substance known as "Bee Propolis" or simply "Propolis" Propolis is a natural substance collected by some species of Honey bees; it is a resinous, gummy material that has many therapeutic properties and can also be used as a natural binder in the dosage form due to its good binding abilities and, it can also give a positive synergistic effect when combined with Ibuprofen. In this study, the formulation was developed as a matrix dosage system in an oral tablet form with a dose of 400 mg/ tablet. Though not all honey bee species are capable of making propolis some of the honey bee species, such as "Apis mellifera L.", "Apis Dorsata", etc. in India are capable of making Propolis. Propolis has 350-500 chemical constituents which can be used in many therapeutic activities; such chemical constituents present in a single product makes it more valuable in further research. INTRODUCTION:Ibuprofen is a Non-steroidal Anti-inflammatory class drug used to reduce fever and relieve minor pain and aches and also for arthritis and other minor aches 21,22 . The minimum dose of Ibuprofen is 300 mg a day, and the maximum dose of Ibuprofen is 3200 mg/ day 22 .

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Synergistic Effects of Propolis Combined with 2-Phenoxyethanol and Antipyretics on the Growth of Staphylococcus aureus

Cited by 10 publications

References 60 publications

Biological Activity of Propolis: An Update

Biological Activity of Propolis: An Update

Avances en las formulaciones de los antisépticos

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