Synergistic Effects of Taurine and Temozolomide Via Cell Proliferation Inhibition and Apoptotic Induction on U-251 MG Human Glioblastoma Cells

Abstract

22 (12), 4001-4009 is the most common brain tumor and has been found in people worldwide, including in Thailand (Miranda-Filho et al., 2017;Witthayanuwat et al., 2018). Major signs and symptoms of GBM include motor weakness in the beginning, progressive headache, and convulsion. Other signs and symptoms depend on brain areas that the tumor invades into such as hemiparesis, visual loss, and aphasia. The definite cause of this tumor is unknown; however, there are some theories proposed that it might cause by genetic factors, race or, people who have ever received radiation therapy on head-to-neck area (Urbańska et al., 2014). This disease has a poor prognosis, and its survival rate is approximately 13-16 months (Shergalis et al., 2018; Urbańska et al., 2014;Bleeker et al., 2012). The current standard treatments for GBM patients include

Camboginol and Morelloflavone from Garcinia dulcis (Roxb.) Kurz Flower Extract Promote Autophagic Cell Death against Human Glioblastoma Cells through Endoplasmic Reticulum Stress

“…Long-term administration of purified camboginol or morelloflavone from G. dulcis for GBM prevention is warranted. Additionally, medication combinations to treat GBM and reduce adverse drug effects are interesting ( Surarak et al, 2021 ). A combination of temozolomide, a conventional chemotherapeutic drug against GBM with camboginol, and morelloflavone would also be further applied.…”