Synergistic effects of tetramethylpyrazine and astragaloside IV on spinal cord injury via alteration of astrocyte A1/A2 polarization through the Sirt1-NF-κB pathway

Rao, Yaojian; Li, Junjie; Qiao, Ruofei; Luo, Jinxin; Liu, Yan

doi:10.1016/j.intimp.2024.111686

Cited by 6 publications

(2 citation statements)

References 52 publications

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“…Most importantly, ligustrazine also inhibited ROS overproduction and alleviated decreased mitochondrial potential, emphasizing the important role of TCM antioxidative therapies in the management of migraine headaches. Although ligustrazine has shown great potential in relieving migraine and neuroinflammation, the clinical treatment of migraine is mostly based on the use of mixed formulations of several Chinese herbs, mainly Chuanxiong , Astragalus , Tianma , etc ., and there have been reports suggesting synergistic or facilitating effects between ligustrazine and other Chinese herbal ingredients [ 57 , 58 ]. Therefore, in this study, we focused only on ligustrazine itself and ignored other herbal components, which is another limitation of this work.…”

Section: Discussionmentioning

confidence: 99%

Dopamine D2 Receptor Activation Blocks GluA2/ROS Positive Feedback Loop to Alienate Chronic-Migraine-Associated Pain Sensitization

Zhang,

Lei

et al. 2024

Antioxidants

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Chronic migraine is a disabling disorder without effective therapeutic medicine. AMPA receptors have been proven to be essential to pathological pain and headaches, but the related regulatory mechanisms in chronic migraine have not yet been explored. In this study, we found that the level of surface GluA2 was reduced in chronic migraine rats. Tat-GluR23Y (a GluA2 endocytosis inhibitor) reduced calcium inward flow and weakened synaptic structures, thus alleviating migraine-like pain sensitization. In addition, the inhibition of GluA2 endocytosis reduced the calcium influx and alleviated mitochondrial calcium overload and ROS generation in primary neurons. Furthermore, our results showed that ROS can induce allodynia and GluA2 endocytosis in rats, thus promoting migraine-like pain sensitization. In our previous study, the dopamine D2 receptor was identified as a potential target in the treatment of chronic migraine, and here we found that dopamine D2 receptor activation suppressed chronic-migraine-related pain sensitization through blocking the GluA2/ROS positive feedback loop in vivo and in vitro. Additionally, ligustrazine, a core component of ligusticum chuanxiong, was shown to target the dopamine D2 receptor, thereby alleviating ROS production and abnormal nociception in CM rats. This study provides valuable insight into the treatment of chronic migraine.

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Section: Discussionmentioning

confidence: 99%

Dopamine D2 Receptor Activation Blocks GluA2/ROS Positive Feedback Loop to Alienate Chronic-Migraine-Associated Pain Sensitization

Zhang,

Lei

et al. 2024

Antioxidants

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“…At the same time, NF-κB can also mediates the inflammatory response of microglia cells [ 27 , 28 ]. Numerous studies have highlighted the crucial role of NF-κB in the pathogenesis of SCI-induced pain [ 29 – 31 ]. Meanwhile, Daphnoretin has shown promise in attenuating inflammation in various diseases [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Daphnoretin inhibited SCI-induced inflammation and activation of NF-κB pathway in spinal dorsal horn

Wu,

Lin,

Chen

2024

Aging

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Objective: Spinal cord injury (SCI) is a devastating disease for which there is no safe and effective treatment at present. Daphnoretin is a natural discoumarin compound isolated from Wikstroemia indica with various pharmacological activities. Our study aimed to investigate the role of Daphnoretin in NF-κB pathway activation and inflammatory response after SCI. Methods: A mouse SCI model was constructed, and the Basso Mouse Scale Score and subscore were used to evaluate the effect of Daphnoretin on the movement capacity of mice. The effect of Daphnoretin on the activation of glial cells in the mouse model and BV2 cells was observed by immunofluorescence. PCR and ELISA were used to detect the expression of inflammatory factors, and Western blot was performed to detect the protein expression associated with NF-κB pathway. Results: Daphnoretin inhibited the loss of movement ability and the activation of glial cells in mice after SCI, and it also inhibited the activation of NF-κB pathway and the expression of inflammatory factors TNF-α and IL-1β in vivo and in vitro . Conclusions: Daphnoretin can inhibit the activation of NF-κB pathway and the inflammatory response induced by SCI. Our study demonstrates the potential of Daphnoretin on clinical application for the treatment of SCI.

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Edaravone Dexborneol provides neuroprotective effect by inhibiting neurotoxic activation of astrocytes through inhibiting NF-κB signaling in cortical ischemia

Chen,

Li,

Tang

et al. 2024

Brain Research Bulletin

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Synergistic effects of tetramethylpyrazine and astragaloside IV on spinal cord injury via alteration of astrocyte A1/A2 polarization through the Sirt1-NF-κB pathway

Cited by 6 publications

References 52 publications

Dopamine D2 Receptor Activation Blocks GluA2/ROS Positive Feedback Loop to Alienate Chronic-Migraine-Associated Pain Sensitization

Dopamine D2 Receptor Activation Blocks GluA2/ROS Positive Feedback Loop to Alienate Chronic-Migraine-Associated Pain Sensitization

Daphnoretin inhibited SCI-induced inflammation and activation of NF-κB pathway in spinal dorsal horn

Edaravone Dexborneol provides neuroprotective effect by inhibiting neurotoxic activation of astrocytes through inhibiting NF-κB signaling in cortical ischemia

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