Synergistic Effects of the Jackfruit Seed Sourced Resistant Starch and Bifidobacterium pseudolongum subsp. globosum on Suppression of Hyperlipidemia in Mice

Zeng, Zhen; Wang, Yuanyuan; Zhang, Yanjun; Chen, Kaining; Chang, Haibo; Ma, Chenchen; Jiang, Shuaiming; Huo, Dongxue; Liu, Wenjun; Jha, Rajesh; Zhang, Jiachao

doi:10.3390/foods10061431

Cited by 18 publications

(8 citation statements)

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“…Although, RS obtained by food processing needs chemical-physical structure characterization [22][23][24][25][26][27][28][29][30]. To this, several techniques to determine their crystallinity, structural order, chain-length distribution and conformation, helicity, as well as double-helical structures are used [31][32][33][34][35][36][37][38]. These include: (i) scanning electron microscopy (SEM), (ii) differential scanning calorimetry (DSC), (iii) X-ray diffraction (XRD) analysis, (iv) solid-state 13 C nuclear magnetic resonance ( 13 C-NMR), (v) permethylation-GC-MS and (vi) Fourier transform infrared spectroscopy (FT-IR).…”

Section: Type Of Resistant Starch and Its Content In Mediterranean Foodmentioning

confidence: 99%

Resistant Starches and Non-Communicable Disease: A Focus on Mediterranean Diet

Cione

Fazio

Curcio

et al. 2021

Foods

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Resistant starch (RS) is the starch fraction that eludes digestion in the small intestine. RS is classified into five subtypes (RS1–RS5), some of which occur naturally in plant-derived foods, whereas the others may be produced by several processing conditions. The different RS subtypes are widely found in processed foods, but their physiological effects depend on their structural characteristics. In the present study, foods, nutrition and biochemistry are summarized in order to assess the type and content of RS in foods belonging to the Mediterranean Diet (MeD). Then, the benefits of RS consumption on health are discussed, focusing on their capability to enhance glycemic control. RS enters the large bowel intestine, where it is fermented by the microbiome leading to the synthesis of short-chain fatty acids as major end products, which in turn have systemic health effects besides the in situ one. It is hoped that this review will help to understand the pros of RS consumption as an ingredient of MeD food. Consequently, new future research directions could be explored for developing advanced dietary strategies to prevent non-communicable diseases, including colon cancer.

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Section: Type Of Resistant Starch and Its Content In Mediterranean Foodmentioning

confidence: 99%

Resistant Starches and Non-Communicable Disease: A Focus on Mediterranean Diet

Cione

Fazio

Curcio

et al. 2021

Foods

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“…Differently, compared with the donkey, sampling method had more signi cently in uence on the cow. In the fecal samples, Bi dobacterium pseudolongum, predominant in cow dung and never be isolated in human feces [44], had the ability of the jackfruit seed sourced resistant starch utilization [45]. Lachnospiraceae bacterium may in uenced the development of obesity and diabetes [46].…”

Section: Discussionmentioning

confidence: 99%

Metagenomic analysis reveals the composition and function of intestinal microbiota were affected by different sampling methods and digestive tract segments in monogastric and polygastric animals

Guo

Shi

et al. 2023

Preprint

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Background: As a domesticated species vital to humans, cow and donkey are raised worldwide as a source of agricultural industry and food production. The digestion and absorption must rely on the division of labor and cooperation of all the digestive tract segments and microbes. The microbiota plays an important role in the health, diseases, athletic performance, weight and digestion of food in animals. The composition and function of microbial community are closely related to the animals’ physiological structure. Moreover, experimental techniques, like the sampling method, could also influence the identification results. Results: Here, using approximately 300 GB of metagenomic sequencing data from digestive tract samples from 91 samples that represent six (donkeys) and nine (cows) digestive tract segment with swab and fecal samples of monogastric (donkeys) and polygastric (cows) animals. We assembled 4,004,115 (cow) and 2,938,653 (donkey) microbial metagenome assembled contigs, and obtained 9,060,744 genes with an average of 553bp (range 102bp ~ 10,912bp) were obtained by clustering at 95% identity and 90% coverage. There were certainly influences on the microbiota with two sampling methods and fecal sample was recommended due to more abundant diversity of species compared with swab sample. Besides, microbiota in the stomach was significantly different from other segments and colon held the most abundant bacteria in the other intestine. In addition, the microbial community structure of donkey was obviously different from cow for both dominant and endemic microbes. There were 1,942 genera that were characterized by high Lactobacillus, Clostridium and Prevotella in the donkey while 1,744 genera were recognized in the cow. Differ from the donkey, different segments of the cow had different dominate genera such Prevotellafor the stomach, Kandleria for the small intestine and Clostridium for the hindgut. Conclusions: Overall, we solved the scientific problem of fecal sample could more objectively reflect the intestinal microbial community. Meanwhile, the microbial composition showed the shared and distinct features of digestive tract segments in different type animals. Our experimental design and dataset provides a valuable resource for discovery of performance-enhancing microbes and systematic studies of cow and donkey microbiome.

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“…Therefore, polyamines may be tested to prevent bone destruction associated with chronic infections in obesity/T2D, where mice at 21 days postinfection show significantly more bone loss than lean/control mice ( 47 ). We suggest that the changes in the gut microbiota, including increased B. pseudolongum abundance, likely lead to increased systemic polyamine production for several reasons: (i) experiments with various Bifidobacteria species demonstrated their capability to produce spermidine in vitro , (ii) shotgun metagenomic sequencing of gut microbiota from obese mice fed resistant starch indicated that polyamine synthesis was associated with increases in B. pseudolongum , and (iii) treatment of mice with arginine and Bifidobacterium animalis led to increased levels of circulating and colonic polyamines, which corresponded with decreased levels of TNF-α and IL-6 ( 76 – 78 ). The evidence from our work demonstrated that polyamines were significantly upregulated in the gut, where microbes are abundant ( Fig.…”

Section: Discussionmentioning

confidence: 99%