Synergistic effects of Woodfordia fruticosa gold nanoparticles in preventing microbial adhesion and accelerating wound healing in Wistar albino rats in vivo

Raghuwanshi, Navdeep; Kumari, Poonam; Srivastava, Amit Kumar; Vashisth, Priya; Yadav, Tara Chand; Prasad, Ramasare; Pruthi, Vikas

doi:10.1016/j.msec.2017.05.134

Cited by 59 publications

(38 citation statements)

References 46 publications

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“…To evaluate the wound‐healing process efficiency, monitoring all the changes during the treatment process is of vital importance. Accordingly, the wound area was traced and measured to quantify the percentage of wound closure using the following (1), [17] on days 6, 12 and 18 after wounding

normalPercentageclosure ()(, %) = ()(, A_{z} - A_{t} / A_{z}) \times 100

where A t is the wound area on corresponding days and A z is the wound area on day 0.…”

Section: Methodsmentioning

confidence: 99%

Biologically‐synthesised ZnO/CuO/Ag nanocomposite using propolis extract and coated on the gauze for wound healing applications

Bayrami

Habibi‐Yangjeh

et al. 2020

IET nanobiotechnol.

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normalPercentageclosure ()(, %) = ()(, A_{z} - A_{t} / A_{z}) \times 100

where A t is the wound area on corresponding days and A z is the wound area on day 0.…”

Section: Methodsmentioning

confidence: 99%

Biologically‐synthesised ZnO/CuO/Ag nanocomposite using propolis extract and coated on the gauze for wound healing applications

Bayrami

Habibi‐Yangjeh

et al. 2020

IET nanobiotechnol.

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“…A further decrease was observed using the aminosaccharide-based gold nanoparticles (<40%). Raghuwanshi et al [125] combined Woodfordia fruticosa extract with gold nanoparticles to prevent microbial biofilms and enhance skin wound healing. Fresh flowers of W. fruticosa were used for rapid wound healing [126].…”

Section: Topically Applying Nanoparticles To Treat Cutaneous Biofilms 61 Metallic Nanoparticlesmentioning

confidence: 99%

The Antibiofilm Nanosystems for Improved Infection Inhibition of Microbes in Skin

et al. 2021

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Biofilm formation is an important virulence factor for the opportunistic microorganisms that elicit skin infections. The recalcitrant feature of biofilms and their antibiotic tolerance impose a great challenge on the use of conventional therapies. Most antibacterial agents have difficulty penetrating the matrix produced by a biofilm. One novel approach to address these concerns is to prevent or inhibit the formation of biofilms using nanoparticles. The advantages of using nanosystems for antibiofilm applications include high drug loading efficiency, sustained or prolonged drug release, increased drug stability, improved bioavailability, close contact with bacteria, and enhanced accumulation or targeting to biomasses. Topically applied nanoparticles can act as a strategy for enhancing antibiotic delivery into the skin. Various types of nanoparticles, including metal oxide nanoparticles, polymeric nanoparticles, liposomes, and lipid-based nanoparticles, have been employed for topical delivery to treat biofilm infections on the skin. Moreover, nanoparticles can be designed to combine with external stimuli to produce magnetic, photothermal, or photodynamic effects to ablate the biofilm matrix. This study focuses on advanced antibiofilm approaches based on nanomedicine for treating skin infections. We provide in-depth descriptions on how the nanoparticles could effectively eliminate biofilms and any pathogens inside them. We then describe cases of using nanoparticles for antibiofilm treatment of the skin. Most of the studies included in this review were supported by in vivo animal infection models. This article offers an overview of the benefits of nanosystems for treating biofilms grown on the skin.

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“…Inspired by the high chemical process activity of natural metallo enzymes, M-N-C SACs with similar structures of natural metalloenzymes were exploited as single-atom nanozymes to mimic the chemical process activities of natural enzymes. Atomically distributed single metal atoms supported on carbon spheres (denoted as PMCS) were fictitious as singleatom nanozyme (SAzyme) with predominant peroxidase-mimicking activity for suppressing the microorganism proliferation and facilitating the wound regeneration [89,90].…”

Section: Wound Healingmentioning

confidence: 99%

The role of biotechnology in the field of biomedical engineering

Datta¹,

Khan²,

Das³

et al. 2021

GSC Biol. and Pharm. Sci.

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The modern age is an arena of interdisciplinary research and knowledge domain which involves versatile field of sciences to work cooperatively for the improvement of the mankind. Biotechnology is providing for more personalized healthcare and continued analysis of the human body. As biotechnology advances day by day, we have to uphold the pace to discover future medical applications of it. Biotechnology is a huge and rapidly growing field. Biomedical technology involves the application of engineering and technology principles to the domain of living or biological systems. Generally biomedical denotes larger stress on issues related to human health and diseases. Different kinds of live expression systems like plant or insect cells, transgenic animals, mammals, yeast, Escherichia coli and more are particularly beneficial because biotechnology-derived medicines from them. This type of expressed gene or protein incorporates the identical nucleotide sequence as endogenous form of humans. Application of biotechnology in different domain of biomedical fields has already brought about a substantial difference which denotes the superiority over traditional ways of treatment. It is very easy to understand that how biotechnology can be played a crucial role in medical purposes. This paper will try to highlight the glimpse of multifaceted application of biotechnology in different field as well as from different angle of application.

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Synergistic effects of Woodfordia fruticosa gold nanoparticles in preventing microbial adhesion and accelerating wound healing in Wistar albino rats in vivo

Cited by 59 publications

References 46 publications

Biologically‐synthesised ZnO/CuO/Ag nanocomposite using propolis extract and coated on the gauze for wound healing applications

Biologically‐synthesised ZnO/CuO/Ag nanocomposite using propolis extract and coated on the gauze for wound healing applications

The Antibiofilm Nanosystems for Improved Infection Inhibition of Microbes in Skin

The role of biotechnology in the field of biomedical engineering

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