Synergistic gangrene of the breast in a patient with type 2 diabetes

Parker, J C; Sabanathan, Sivakumaran

doi:10.1258/shorts.2011.011099

Cited by 7 publications

(4 citation statements)

References 8 publications

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“…Primary breast gangrene was reported previously in an HIV-positive patient as the first presentation with severe necrotizing infections and ended up with mastectomy [5]. Jody and Sivakumaran reported another case of synergistic gangrene of the breast in a patient with type 2 diabetes [8]. Sameer A et al reported a case of right breast gangrene as a complication of puerperal sepsis in a female patient [9].…”

Section: Discussionmentioning

confidence: 99%

A Case of Bilateral Breast Gangrene in Lactating Non Diabetic Young Lady

Mahran¹,

Heeny²

2016

IJCR

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This report describes an unusual case of gangrene affecting the breast in a lactating non-diabetic patient.She was admitted to Minia University hospital complaining of swelling, pain and blackish discoloration of both breasts that was more extensive on the left side. Wound cultures revealed heavy growth of styphalcoccusaureus showing sensitivity to linzeolid, Methicillin and Vancomycin.Blood culture was sterile. Examination revealed that both breasts were large, tender and the gangrene involved all quadrants of the left breast and the medial side of the right breast (15x7 cm). Debridement was carried out and then skin graft was carried out for the left breast and primary closure for the right breast. The objective of this case report is to study clinical presentation and management of youngfemale with breast gangrene.

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Section: Discussionmentioning

confidence: 99%

A Case of Bilateral Breast Gangrene in Lactating Non Diabetic Young Lady

Mahran¹,

Heeny²

2016

IJCR

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“…The main microbiological agents obtained on culture are mixed anaerobic and aerobic florae ( S aureus , Escherichia coli , bacteroids, proteus, Enterococcus and anaerobic streptococci). Although this disorder carries a high mortality (20–70%),4 early diagnosis and emergent surgical intervention in the form of wide local repeated debridement of the gangrenous breast and proper aseptic dressing along with broad-spectrum and culture-specific antibiotics and other supportive measures can save the patient 5. Once healthy granulation tissue appears split skin grafting can be carried out.…”

Section: Discussionmentioning

confidence: 99%

Breast gangrene: a rare source of severe sepsis

2014

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We present a very rare case of breast gangrene in a 26-year-old woman, lactating primipara, referred to the emergency department of our hospital with a 1-day history of difficulty in breathing, high-grade fever associated with chills and rigor and failure to pass urine. After initial resuscitation, stabilisation and thorough examination her right breast was found to be gangrenous, with satellite lesions at the periphery. Later, under local anaesthesia and appropriate antibiotic coverage, the patient was taken for emergency debridement. She gradually recovered and as the wound developed healthy granulation tissue and wound culture became sterile, grafting of the affected area was carried out. The graft took well following which she was discharged.

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“…Bacteria isolated from polymicrobial soft tissue infections such as synergistic gangrene and type I necrotising fasciitis include combinations of Gram-positive cocci, Gram-negative bacilli and anaerobes e.g., Bacteroides sp. [35,36]. These infections can result from factors such as infected surgical wounds, burns and chronic skin ulcers, all of which can rapidly progress to polymicrobial sepsis [35,36].…”

Section: Infection Sourcesmentioning

confidence: 99%

“…[35,36]. These infections can result from factors such as infected surgical wounds, burns and chronic skin ulcers, all of which can rapidly progress to polymicrobial sepsis [35,36]. While these severe soft tissue infections occur less frequently, they can be fatal if not recognised and treated aggressively [36,37].…”

Section: Infection Sourcesmentioning

confidence: 99%

Molecular Methodologies for Improved Polymicrobial Sepsis Diagnosis

Doualeh

Payne

Litton

et al. 2022

IJMS

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Polymicrobial sepsis is associated with worse patient outcomes than monomicrobial sepsis. Routinely used culture-dependent microbiological diagnostic techniques have low sensitivity, often leading to missed identification of all causative organisms. To overcome these limitations, culture-independent methods incorporating advanced molecular technologies have recently been explored. However, contamination, assay inhibition and interference from host DNA are issues that must be addressed before these methods can be relied on for routine clinical use. While the host component of the complex sepsis host–pathogen interplay is well described, less is known about the pathogen’s role, including pathogen–pathogen interactions in polymicrobial sepsis. This review highlights the clinical significance of polymicrobial sepsis and addresses how promising alternative molecular microbiology methods can be improved to detect polymicrobial infections. It also discusses how the application of shotgun metagenomics can be used to uncover pathogen/pathogen interactions in polymicrobial sepsis cases and their potential role in the clinical course of this condition.

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Synergistic gangrene of the breast in a patient with type 2 diabetes

Cited by 7 publications

References 8 publications

A Case of Bilateral Breast Gangrene in Lactating Non Diabetic Young Lady

A Case of Bilateral Breast Gangrene in Lactating Non Diabetic Young Lady

Breast gangrene: a rare source of severe sepsis

Molecular Methodologies for Improved Polymicrobial Sepsis Diagnosis

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