Synergistic Impact of Xanthorrhizol and <i>d</i>-δ-Tocotrienol on the Proliferation of Murine B16 Melanoma Cells and Human DU145 Prostate Carcinoma Cells

Chan, Darren; Meister, Maureen; Madhani, Chappell; Elfakhani, Manal; Yount, Sophie T.; Ji, Xiangming; Feresin, Rafaela; Wanders, Desiree; Mo, Huanbiao

doi:10.1080/01635581.2020.1807573

Nutrition and Cancer

2020

DOI: 10.1080/01635581.2020.1807573

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Synergistic Impact of Xanthorrhizol and d-δ-Tocotrienol on the Proliferation of Murine B16 Melanoma Cells and Human DU145 Prostate Carcinoma Cells

Darren Chan

Maureen Meister

Chappell Madhani

et al.

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2024

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Cited by 1 publication

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Therapeutic potential of tocotrienols as chemosensitizers in cancer therapy

Sailo,

Chauhan,

Hegde

et al. 2024

Phytotherapy Research

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Chemoresistance is the adaptation of cancer cells against therapeutic agents. When exhibited by cancer cells, chemoresistance helps them to avoid apoptosis, cause relapse, and metastasize, making it challenging for chemotherapeutic agents to treat cancer. Various strategies like dosage modification of drugs, nanoparticle‐based delivery of chemotherapeutics, antibody‐drug conjugates, and so on are being used to target and reverse chemoresistance, one among such is combination therapy. It uses the combination of two or more therapeutic agents to reverse multidrug resistance and improve the effects of chemotherapy. Phytochemicals are known to exhibit chemosensitizing properties and are found to be effective against various cancers. Tocotrienols (T3) and tocopherols (T) are natural bioactive analogs of vitamin E, which exhibit important medicinal value and potential curative properties apart from serving as an antioxidant and nutrient supplement. Notably, T3 exhibits a variety of pharmacological activities like anticancer, anti‐inflammatory, antiproliferative, and so on. The chemosensitizing property of tocotrienol is exhibited by modulating several signaling pathways and molecular targets involved in cancer cell survival, proliferation, invasion, migration, and metastasis like NF‐κB, STATs, Akt/mTOR, Bax/Bcl‐2, Wnt/β‐catenin, and many more. T3 sensitizes cancer cells to chemotherapeutic drugs including cisplatin, doxorubicin, and paclitaxel increasing drug concentration and cytotoxicity. Discussed herewith are the chemosensitizing properties of tocotrienols on various cancer cell types when combined with various drugs and biological molecules.

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Therapeutic potential of tocotrienols as chemosensitizers in cancer therapy

Sailo,

Chauhan,

Hegde

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

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Synergistic Impact of Xanthorrhizol and d-δ-Tocotrienol on the Proliferation of Murine B16 Melanoma Cells and Human DU145 Prostate Carcinoma Cells

Cited by 1 publication

References 46 publications

Therapeutic potential of tocotrienols as chemosensitizers in cancer therapy

Therapeutic potential of tocotrienols as chemosensitizers in cancer therapy

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