Synergistic Impacts of <i>Alpinia oxyphylla</i> Seed Extract and Allopurinol against Experimental Hyperuricemia

Sung, Yoon‐Young; Kim, Dong-Seon

doi:10.1155/2022/2824535

Cited by 8 publications

(1 citation statement)

References 30 publications

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“…The medicinal part is the seed of A. oxyphylla and the crude and salt processed products are commonly used (in) clinically. According to the theories of Traditional Chinese Medicine (TCM), salt processing increased the inclination and direction of AOF's actions, thereby strengthening its efficacy in treatment of renal injury (Sung et al, 2022). The SAOF is more widely used in traditional Chinese medicine prescriptions, such as Suoquan pill, Sanxian pill, which are commonly used in the treatment proteinuria in kidney injury (Shuai et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

Pak. J. Pharm. Sci.,

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Alpinia oxyphylla Fructus is one of the traditional Chinese medicine plants in the treatment of kidney injury. In clinical practice, crude Alpinia oxyphylla Fructus (CAOF) and salt-processed Alpinia oxyphylla Fructus (SAOF) are the two commonly used drugs specificated in the prevention and treatment of diabetic nephropathy (DN). However, the intestinal micro ecology regulation between CAOF and SAOF on DN has not been reported. In this paper, intestinal micro ecology regulation activities between CAOF and SAOF in DN rats were compared and analyzed by short-chain fatty acids (SCFAs) and intestinal flora analysis. The results showed that both SAOF and CAOF can regulate the intestinal flora metabolite SCFAs level in DN rats, reduce blood glucose concentration and improve inflammatory reaction. The intestinal flora analysis showed SAOF and CAOF could increase the intestinal bacterial diversity. The treatment of renal injury may be related to their increased intestinal bacterial diversity.

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Section: Introductionmentioning

confidence: 99%

Untitled

2023

Pak. J. Pharm. Sci.,

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Herbal remedies in the management of hyperuricemia and gout: A review of in vitro, in vivo and clinical evidences

Mahomoodally,

Coodian,

Hosenally

et al. 2024

Phytotherapy Research

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Gout, or hyperuricemia is a multifactorial and multi‐faceted metabolic disease that is quite difficult to manage and/or treat. Conventional therapies such as non‐steroidal anti‐inflammatory drugs (NSAIDs) such as allopurinol, corticosteroids and colchicine amongst others, have helped in its management and treatment to some extent. This study aimed to compile and analyze the different herbal remedies used in the management of hyperuricemia and gout. A literature search was conducted from key databases (PubMed, ScienceDirect, Cochrane Library, Google Scholar) using relevant keywords via the PRISMA model. Smilax riparia A.DC. from Traditional Chinese Medicine is used in many countries for its therapeutic effect on lowering serum urate levels. No single study was able to establish the efficacy of a specific traditionally used herb via in vitro, in vivo, and clinical studies. Patients were found to use a panoply of natural remedies, mainly plants to treat hyperuricemia and gout, which have been validated to some extent by in vitro, in vivo, and clinical studies. Nonetheless, further research is needed to better understand the ethnopharmacological relationship of such herbal remedies.

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