Synergistic interaction of endogenous platelet-activating factor and vasopressin in generating angina in rats

Psychological support and outcomes for ICU patients

“…Stress stimuli are non‐specific, that is, psychological stressors display similar neurohormonal and secretagogue patterns, as well as psycho‐physiologic effects, as those described for physiological stressors (Scantamburlo et al , 2001). A large body of evidence on the impact of emotion, stress and coping style on physiology exists implying that stress and its molecules (neuropeptides, neurotransmitters and cytokines), through their peripheral receptors (Zukowska et al , 2003), may contribute to derangements prevalent in critical illness, including systemic inflammation (Elenkov et al , 2000), cellular stress and oxidative damage (Tanabe et al , 2001; Sivonová et al , 2004; Sobocanec et al , 2005), endothelial dysfunction and coagulopathies (von Känel et al , 2001; Nemccsik et al , 2004), which precipitate high mortality and morbidity. In addition, other evidence suggests that positive affective states, such as hope and relaxation may reverse these adverse consequences (DeWitt et al , 2000; Gitto et al , 2001; Meng et al , 2002).…”

Mentha longifolia alleviates experimentally induced angina via decreasing cardiac load

“…On the other hand, vasopressin stimulates coronary arteries vasoconstriction and hence increases total coronary resistance. Therefore, vasopressin‐induced angina is a useful model for evaluating the antianginal activities (Nemcsik et al, ).…”

Scientific revolutions and the structure of critical care

“…It is their bodies’ integrated neuroendocrine immune response (Baue et al ., 1998; Van den Berghe, 2002) generating various dysfunctions at organismic and cellular level (Fink and Evans, 2002; Lin and Hopf, 2003) that essentially determines outcome. Evidence exists that stress and its molecules (neuropeptides, neurotransmitters and even cytokines), through ample peripheral receptors (Zukowska et al ., 2003), contribute to the exaggeration of inflammation (Elenkov et al ., 2000), cellular stress (heat shock and apoptosis) (Tanabe et al ., 2001) oxidative damage (Sivonová et al ., 2004; Sobocanec et al ., 2005), endothelial dysfunction and coagulopathies (von Känel et al ., 2001; Nemcsik et al ., 2004), phenomena prevalent in critical illness, which are also associated with poor patient outcomes. In addition, scarcer but not less compelling evidence suggests that positive affective states, such as hope and relaxation, through specific neuropeptides, may reverse these adverse consequences (DeWitt et al ., 2000; Gitto et al ., 2001; Meng et al ., 2002).…”