Synergistic interactions of cadmium-free quantum dots embedded in a photosensitised polymer surface: efficient killing of multidrug-resistant strains at low ambient light levels

Owusu, Ethel G. A.; Yaghini, Elnaz; Naasani, Imad; Parkin, Ivan P.; Allan, Elaine; MacRobert, Alexander J.

doi:10.1039/c9nr10421f

Cited by 7 publications

(10 citation statements)

References 72 publications

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“…To restrict the use of toxic cadmium, Owusu et al 113 developed indium phosphide quantum dots (InP QDs) via a proprietary molecular seeding procedure. The QDs-CV complex was incorporated into PU via the swell-encapsulation-shrink dipping technique, and the obtained PU/QDs-CV film was evaluated for its antibacterial effect on E. coli and P. aeruginosa (Figure 6).…”

Section: Other Metal and Metal Oxide Nanoparticles-incorporated Polyu...mentioning

confidence: 99%

“…The fabricated PU and PU nanocomposites were examined for their antibacterial activity against S. aureus and E. coli bacteria. Even after 24 h of F I G U R E 6 Preparation of antibacterial PU with InP QDs and CV via a non-covalent dipping process 113 [Color figure can be viewed at wileyonlinelibrary.com] incubation, the cell viability was not affected by the presence of pure PU, whereas the GO-and rGO-incorporated PU nanocomposites showed a 100% reduction in cell viability. The graphite-derived PU nanocomposite film displayed 63% inhibition for E. coli and 42% inhibition for S. aureus after 24 h. The antimicrobial action of grapheneincorporated PU nanocomposites may be attributed to the introduction of membrane and oxidation stress (Figure 8).…”

Section: Carbon Materials-based Polyurethane Compositesmentioning

confidence: 99%

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Polyurethane‐basedcomposites with promising antibacterial properties

Kasi

Sathishkumar

Zhang

et al. 2022

J of Applied Polymer Sci

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Polyurethane (PU) is a well-known synthetic polymer consisting of isocyanates, polyols, and chain extenders. The incorporation of fillers into the PU polymeric matrix, including inorganic nanomaterials, synthetic polymers, natural components, quaternary ammonium salts, and commercial drugs, bestows the endproducts with unique and improved physicochemical properties. Fillers can be used to tailor the molecular orientation, crystallinity, cross-linking, and functional chemical groups of PU-based composites. The bactericidal ability of PU composites highly depends on their surface composition, morphology, charge, and stability. Recent advancements highlight the potential of PU composites in combating bacterial infections. In this review, the cutting-edge of inorganic and organicbased PU composites for antibacterial applications is addressed. Notably, selective examples of scientific reports' key findings and their crucial information on PU composites are discussed. Furthermore, the positive impact of PU composites on the future prospects of this field is explored. This review comprehensively deliberates the values of PU composites towards practical applications in the biomedical field of antibacterial activity. This review can help researchers to gain widespread knowledge and a better understanding of PU composites for antibacterial applications.

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Section: Other Metal and Metal Oxide Nanoparticles-incorporated Polyu...mentioning

confidence: 99%

Section: Carbon Materials-based Polyurethane Compositesmentioning

confidence: 99%

Polyurethane‐basedcomposites with promising antibacterial properties

Kasi

Sathishkumar

Zhang

et al. 2022

J of Applied Polymer Sci

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“…It is suggested that there are two pathways, known as Type I and Type II mechanisms. As proposed by Owusu and cols [ 94 , 95 ] Type I mechanism involves photo-electron transfer (PET) to generate free radicals such as superoxide anions and hydroxyl radicals. The Type II mechanism involves the formation of reactive singlet oxygen ( 1 O 2 ) from a direct energy transfer from the phtosensitizer to molecular oxygen.…”

Section: Polymeric Materials With Antibacterial Activitymentioning

confidence: 99%

“…Both mechanisms contribute to the formation of ROS that kill bacteria. As the purpose of this study is the use of these complexes in medicine, cadmium free quantum dots were proposed [ 94 ]. The photoactivable mechanism is also proposed in a household solar water disinfection device, where self-supported TiO 2 is placed inside polyethylene terephthalate (PET) bottles to produce clean household water [ 95 ].…”

Section: Polymeric Materials With Antibacterial Activitymentioning

confidence: 99%

Polymeric Materials with Antibacterial Activity: A Review

Olmos

González‐Benito

2021

Polymers

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Infections caused by bacteria are one of the main causes of mortality in hospitals all over the world. Bacteria can grow on many different surfaces and when this occurs, and bacteria colonize a surface, biofilms are formed. In this context, one of the main concerns is biofilm formation on medical devices such as urinary catheters, cardiac valves, pacemakers or prothesis. The development of bacteria also occurs on materials used for food packaging, wearable electronics or the textile industry. In all these applications polymeric materials are usually present. Research and development of polymer-based antibacterial materials is crucial to avoid the proliferation of bacteria. In this paper, we present a review about polymeric materials with antibacterial materials. The main strategies to produce materials with antibacterial properties are presented, for instance, the incorporation of inorganic particles, micro or nanostructuration of the surfaces and antifouling strategies are considered. The antibacterial mechanism exerted in each case is discussed. Methods of materials preparation are examined, presenting the main advantages or disadvantages of each one based on their potential uses. Finally, a review of the main characterization techniques and methods used to study polymer based antibacterial materials is carried out, including the use of single force cell spectroscopy, contact angle measurements and surface roughness to evaluate the role of the physicochemical properties and the micro or nanostructure in antibacterial behavior of the materials.

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“…CV has been chosen for this purpose since it has been reported as a fluorescent marker to study the traverse effect on the Escherichia coli peptidoglycan membrane, as a fluorescent discriminator for the G-quadruplex complex, and so forth. − CV-anchored magnetofluorescent nanoparticles were also designed for the detection of bacteria by μ-NMR and optical imaging as point-of-care diagnostics . Cadmium-free quantum dots and CV have been explored as FRET pairs to generate photoactivated reactive oxygen species, and solution-based spectroscopic methods (not image-based assay) were explored to study their antimicrobial activity. , Until now, no effort has been made to explore the image-based FRET assay in bacterial research. In the present investigation, a novel strategy is introduced, wherein an on-site bacterial membrane-reinforced FRET gate was created using an AIE-active polymer gatekeeper (donor) to localize the CV biomarker (acceptor).…”

Section: Introductionmentioning

confidence: 99%

Theranostic FRET Gate to Visualize and Quantify Bacterial Membrane Breaching

Ghosh

Jayakannan

2023

Biomacromolecules

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Designing new antimicrobial-cum-probes to study realtime bacterial membrane breaching and concurrently developing inquisitorial image-based analytical tools is essential for the treatment of infectious diseases. An array of aggregation-induced emission (AIE) polymers (donor) consisting of neutral, anionic, and cationic charges were designed and employed as antimicrobial theranostic gatekeepers for the permeabilization of the peptidoglycan layer-adherable crystal violet (CV, acceptor). An AIE-active tetraphenylethylene (TPE)-tagged polycaprolactone biodegradable platform was chosen, and their selfassembled tiny amphiphilic nanoparticles were employed as a gatekeeper in the construction of bacterial membrane-reinforced fluorescent resonance energy transfer (FRET) probes. Electrostatic adhering of the cationic AIE polymer and subsequent gate opening aided fluorescent FRET probe activation on the membrane of Gram-negative bacteria, Escherichia coli. The selective photoexcitation energy transfer process in confocal microscopy experiments facilitated the building of a visualization-based FRET assay for the quantification of bactericidal activity. Nonantimicrobial AIE polymers (neutral and anionic) did not breach the bacterial membrane, resulting in no FRET signal. Detailed photophysical studies were done to establish the FRET probe mechanism, and a proof of concept was established.

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Synergistic interactions of cadmium-free quantum dots embedded in a photosensitised polymer surface: efficient killing of multidrug-resistant strains at low ambient light levels

Abstract: Polyurethane incorporated with cadmium-free quantum dots and crystal violet dye kill >99.9% of multi-drug resistant and intrinsically resistant clinical strains of bacteria under ambient light irradiation.

Cited by 7 publications

References 72 publications

Polyurethane‐basedcomposites with promising antibacterial properties

Polyurethane‐basedcomposites with promising antibacterial properties

Polymeric Materials with Antibacterial Activity: A Review

Theranostic FRET Gate to Visualize and Quantify Bacterial Membrane Breaching

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