Synergistic Potential of Dillapiole Combined With Pyrethroids against Mosquitoes

Gomes, Erika Oliveira; Nunomura, Sergio Massayoshi; Marinotti, Osvaldo; Tadei, erli Pedro

doi:10.4172/2473-4810.1000114

Cited by 5 publications

(7 citation statements)

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“…Pharmacoenhancement by dillapiol was demonstrated in mice acutely infected with Piper berghei, where we found that dillapiol has no antimalarial activity but greatly enhanced the plasma levels and efficacy of the antimalarial compound gedunin . The synergistic potential of dillapiol combined with pyrethroids against mosquitoes had also been described …”

Section: Introductionsupporting

confidence: 60%

“…4 The synergistic potential of dillapiol combined with pyrethroids against mosquitoes had also been described. 5…”

Section: Introductionmentioning

confidence: 99%

“…4 The synergistic potential of dillapiol combined with pyrethroids against mosquitoes had also been described. 5 Dillapiol has also been long known as an insecticide synergist. A recent study reported that dillapiol effectively synergized the efficacy of pyrethrin in resistant strains of Colorado potato beetle.…”

Section: ■ Introductionmentioning

confidence: 99%

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Potent CYP3A4 Inhibitors Derived from Dillapiol and Sesamol

et al. 2019

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Synthesis of 50 analogues of the natural insecticide synergists, dillapiol and sesamol, is reported. These were evaluated as potential insecticide synergists based on their inhibition of human CYP3A4. The most potent inhibitors have a relatively large hydrophobic substituent at either position 5 or 6 of these molecules. For example, 5-(benzyloxy)-6-(3-phenylsulfonyl)propyl)benzo[ d ][1,3]dioxole ( 18 ) and the diphenyl acetate of (6,7-dimethoxybenzo[ d ][1,3]dioxol-5-yl)propan-1-ol ( 5n ) show inhibitory concentrations for 50% activity IC 50 values of 0.086 and 0.2 μM, respectively. These compounds are 106 and 46 times more potent than dillapiol whose IC 50 for the inhibition of CYP3A4 is 9.2 μM. The ortho -chloro analogue ( 8f ), whose activity is 86 times the activity of dillapiol, is the most potent of the fourteen 5-(benzyloxy-6-(2 propenyl)benzo[ d ][1,3]dioxoles prepared for this study.

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Section: Introductionsupporting

confidence: 60%

“…4 The synergistic potential of dillapiol combined with pyrethroids against mosquitoes had also been described. 5…”

Section: Introductionmentioning

confidence: 99%

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Potent CYP3A4 Inhibitors Derived from Dillapiol and Sesamol

et al. 2019

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“…This finding can be explained by the high content of dill apiole 39 (94.1 %) in the tested EO, known for its insecticidal activity . Gomes et al . found that combination of dill apiole/pyrethroids exhibited a synergistic effect in controlling Aedes aegypti and Anopheles albitarsis mosquitos.…”

Section: Resultsmentioning

confidence: 99%

“…Biodiversity 2020, 17, e1900552 www.cb.wiley.com (4 of 13) e1900552 © 2020 Wiley-VHCA AG, Zurich, Switzerland insecticidal activity. [59][60][61][62][63] Gomes et al [64] found that combination of dill apiole/pyrethroids exhibited a synergistic effect in controlling Aedes aegypti and Anopheles albitarsis mosquitos. In addition, dill apiole 39 synergistically interacted with several insecticides, against the mosquito larvae Aedes atropalpus and the flour beetle Tribolium castaneum.…”

Section: Repellent Activitymentioning

confidence: 99%

Chemical Composition and Insecticidal Activity of Crithmum Maritimum L. Essential Oil against Stored‐Product Beetle Tribolium Castaneum

Mustapha

Zardi‐Bergaoui

Chaieb

et al. 2020

Chemistry & Biodiversity

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Several plant essential oils have been used against diverse insect pests since, unlike conventional pesticides, they pose almost no risk to humans and the environment. For this reason, the essential oil (EO) isolated from the fresh leaves of Crithmum maritimum L. and its fractions (F1–F5) obtained by chromatographic simplification were investigated for their chemical profile, as well as for their toxicity and repellency effects against Tribolium castaneum (Herbst) adults. The analysis by GC/MS allowed the identification of 92.8–99.1 % of the compositions of the total oil (EO) and of its fractions (F1–F5). The EO and its fractions F3–F5 were characterized by the presence of a high amount of phenylpropanoids (94.4, 94.8, 93.6, and 88.7 %, respectively): in all the samples, dill apiole was the most abundant component (EO: 94.1 %, F3: 94.6 %, F4: 93.4 %, and F5: 83.3 %). In addition, the repellency assay results showed that the volatile fraction F5 and the complete EO exhibited a higher repellency towards T. castaneum (97 % and 93 %, respectively) after 2 h of exposure at the dose of 0.04 μL/cm2. The median lethal dose of the topical application of the EO was 9 %. Furthermore, the fraction F1 possessed interesting contact toxicity against T. castaneum (80 % of mortality) at the concentration of 10 %. These results suggested that the essential oil of C. maritimum leaves might be used as an alternative to synthetic insecticides in order to prevent insects from damaging the stored products.

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