Synergistic properties of cellulases from Clostridium cellulovorans in the presence of cellobiose

Yamamoto, Kosuke; Tamaru, Yutaka

doi:10.1186/s13568-015-0169-5

Cited by 53 publications

(71 citation statements)

References 24 publications

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“…The T3SS proteins interfere with the pro-angiogenic action of the growth factors in tumors. Administration of ST8/pSEndo in murine CT26 colon cancer mice showed effective tumor regression with low blood vessel density and severe tumor necrosis as compared to a mock control ST8/pSGFP [ 8 ]. Potent anti-angiogenic and tumor vessel normalization properties of Histidine-proline-rich glycoprotein (HPRG) were introduced in S. typhimurium VNP20009 strain under the control of hypoxia-induced NirB promoter.…”

Section: Mechanism Of Tumor Suppressionmentioning

confidence: 99%

“…Genetic engineering and synthetic biology are essential tools to bioengineer therapeutic bacteria to maximize their efficiency in cancer treatment. Bacteria can be genetically engineered and used as direct oncolytic agents or as vectors for delivery of gene therapy, cytotoxic agents, and peptides [ 8 , 9 , 10 ]. Species of Clostridia, Bifidobacteria , and Salmonellae are commonly used as vectors for delivery of tumor suppressor genes, tumor associated antigens, or suicide genes [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Bacteria can be genetically engineered and used as direct oncolytic agents or as vectors for delivery of gene therapy, cytotoxic agents, and peptides [ 8 , 9 , 10 ]. Species of Clostridia, Bifidobacteria , and Salmonellae are commonly used as vectors for delivery of tumor suppressor genes, tumor associated antigens, or suicide genes [ 8 ]. The use of bacterial anti-cancer therapy in conjunction with the conventional cancer therapy as effective treatment options have also been described.…”

Section: Introductionmentioning

confidence: 99%

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Microbes as Medicines: Harnessing the Power of Bacteria in Advancing Cancer Treatment

Sawant

Patil

Gupta

et al. 2020

IJMS

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Conventional anti-cancer therapy involves the use of chemical chemotherapeutics and radiation and are often non-specific in action. The development of drug resistance and the inability of the drug to penetrate the tumor cells has been a major pitfall in current treatment. This has led to the investigation of alternative anti-tumor therapeutics possessing greater specificity and efficacy. There is a significant interest in exploring the use of microbes as potential anti-cancer medicines. The inherent tropism of the bacteria for hypoxic tumor environment and its ability to be genetically engineered as a vector for gene and drug therapy has led to the development of bacteria as a potential weapon against cancer. In this review, we will introduce bacterial anti-cancer therapy with an emphasis on the various mechanisms involved in tumor targeting and tumor suppression. The bacteriotherapy approaches in conjunction with the conventional cancer therapy can be effective in designing novel cancer therapies. We focus on the current progress achieved in bacterial cancer therapies that show potential in advancing existing cancer treatment options and help attain positive clinical outcomes with minimal systemic side-effects.

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Section: Mechanism Of Tumor Suppressionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Microbes as Medicines: Harnessing the Power of Bacteria in Advancing Cancer Treatment

Sawant

Patil

Gupta

et al. 2020

IJMS

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“…In the environment, these bacteria may be present in soil and water. 22 Several factors may contribute to the presence of Clostridium species in soil: seasonality, 23 soil type, 24 stagnant (accumulated) water, 25 presence of inhibitors of their enzymatic activity, microorganisms, 26 etc. Moreover, according to the literature, affiliated bacteria with genus Clostridium may be present in sites polluted with hydrocarbons; 27 they are also tolerant to acid mine drainage systems, 28 and resistant to butanol.…”

Section: Extraction Of Dna From Soilmentioning

confidence: 99%

Burkholderia thailandensis: the Main Bacteria Biodegrading Fipronil in Fertilized Soil with Assessment by a QuEChERS/GC-MS Method

Cappelini¹,

Alberice²,

Eugenio³

et al. 2018

J. Braz. Chem. Soc.

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Due to the expansion of sugarcane crops and the high costs of agricultural inputs, an alternative for fertilization of the soil is the use of humic substances (HS) because they improve its physical-chemical properties. The objective of this study was to assess the biological degradation of fipronil in soil supplemented with HS. For determination of fipronil and its metabolites, we validated a quick, easy, cheap, effective, rugged, and safe gas chromatography-mass spectrometry (QuEChERS/GC-MS) method, which yielded detection and quantification limits of 15.0 and 62.5 ng g −1 , respectively. The method presented linearity of 0.99, precision between 1.5 and 10.9%, while the recovery ranged from 78 to 98%, with precision (relative standard deviation (RSD)) < 5%. The strain B. thailandensis of Burkholderia sp. grew under typical conditions for degradation of fipronil. Eight treatments assessed the degradation by B. thailandensis in the presence of HS. The metabolites produced in the experiment, although detected, could not be quantified because they were below the limit of quantification of the method. Our results showed that B. thailandensis has the potential to degrade fipronil, and that HS is not toxic to the microbiota, and does not inactivate fipronil.

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“…When surveying Japanese isolates, we discovered yeasts exhibiting high-level oleaginous potential under various conditions [ 17 , 19 , 20 ]. In the present study, we focused on oleaginous yeasts that could utilize glucose and xylose simultaneously and selected three strains, IPM32-16, ISM28-8s T , and IPM46-17, for evaluation.…”

Section: Introductionmentioning

confidence: 99%

Lipid production via simultaneous conversion of glucose and xylose by a novel yeast, Cystobasidium iriomotense

et al. 2018

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The yeast strains IPM32-16, ISM28-8sT, and IPM46-17, isolated from plant and soil samples from Iriomote Island, Japan, were explored in terms of lipid production during growth in a mixture of glucose and xylose. Phylogenetically, the strains were most closely related to Cystobasidium slooffiae, based on the sequences of the ITS regions and the D1/D2 domain of the LSU rRNA gene. The strains were oleaginous, accumulating lipids to levels > 20% dry cell weight. Moreover, kinetic analysis of the sugar-to-lipid conversion of a 1:1 glucose/xylose mixture showed that the strains consumed the two sugars simultaneously. IPM46-17 attained the highest lipid content (33%), mostly C16 and C18 fatty acids. Thus, the yeasts efficiently converted lignocellulosic sugars to lipids, aiding in biofuel production (which benefits the environment, promotes rural jobs, and strengthens fuel security). The strains constituted a novel species of Cystobasidium, for which we propose the name Cystobasidium iriomotense (type strain ISM28-8sT = JCM 24594T = CBS 15015T).

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Synergistic properties of cellulases from Clostridium cellulovorans in the presence of cellobiose

Cited by 53 publications

References 24 publications

Microbes as Medicines: Harnessing the Power of Bacteria in Advancing Cancer Treatment

Microbes as Medicines: Harnessing the Power of Bacteria in Advancing Cancer Treatment

Burkholderia thailandensis: the Main Bacteria Biodegrading Fipronil in Fertilized Soil with Assessment by a QuEChERS/GC-MS Method

Lipid production via simultaneous conversion of glucose and xylose by a novel yeast, Cystobasidium iriomotense

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