Synergistic regulation of hepatic Fsp27b expression by HNF4α and CREBH

Kasano-Camones, Carlos Ichiro; Takizawa, Masayuki; Iwasaki, W.; Sasaki, Shota; Hamada, Mume; Morimoto, Aoi; Sakaguchi, Masakiyo; Gonzalez, Frank J.; Inoue, Yusuke

doi:10.1016/j.bbrc.2020.05.070

Cited by 7 publications

(2 citation statements)

References 21 publications

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“…De novo fatty acid synthesis relies heavily on ACLY, ACC1, and MOGAT2, all of which are connected to chemoresistance (Sur et al, 2019). ADRP, CIDE, and ACAT1 play key roles in forming lipid droplets in the liver and other peripheral tissues (Ayyagari et al, 2022; Fan et al, 2020; Kasano‐Camones et al, 2020). It has been proposed that ING5‐mediated lipid droplet formation is associated with chemoresistance and that ING5 mRNA expression is positively modulated by the SRF–YY1–ING5–p53 complex in the ING5 promoter region (Gou et al, 2015; Zheng et al, 2022; Zheng et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Section: Effect Of Fam64a Expression On Chemoresistance and Lipid Dro...mentioning

confidence: 99%

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FAM64A aggravates proliferation, invasion, lipid droplet formation, and chemoresistance in gastric cancer: A biomarker for aggressiveness and a gene therapy target

Yun

Yang

et al. 2023

Drug Development Research

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FAM64A is a mitogen‐induced regulator of the metaphase and anaphase transition. Here, we found that FAM64A messenger RNA (mRNA) and protein expression levels were higher in gastric cancer tissue than in normal mucosa (p < .05). FAM64A methylation was negatively correlated with FAM64A mRNA expression (p < .05). The differentially expressed genes of FAM64A were mainly involved in digestion, potassium transporting or exchanging ATPase, contractile fibers, endopeptidase, and pancreatic secretion (p < .05). The FAM64A‐related genes were principally categorized into ubiquitin‐mediated proteolysis, cell cycle, chromosome segregation and mitosis, microtubule binding and organization, metabolism of amino acids, cytokine receptors, lipid droplet, central nervous system, and collagen trimer (p < .05). FAM64A protein expression was lower in normal gastric mucosa than intestinal metaplasia, adenoma, and primary cancer (p < .05), negatively correlated with older age, T stage, lymphatic and venous invasion, tumor, node, metastasis stage, and dedifferentiation (p < .05), and associated with a favorable overall survival of gastric cancer patients. FAM64A overexpression promoted proliferation, antiapoptosis, migration, invasion, and epithelial–mesenchymal transition via the EGFR/Akt/mTOR/NF‐κB, while the opposite effect was observed for FAM64A knockdown. FAM64A also induced chemoresistance directly or indirectly through lipid droplet formation via ING5. These results suggested that upregulation of FAM64A expression might induce aggressive phenotypes, leading to gastric carcinogenesis and its subsequent progression. Thus, FAM64A could be regarded as a prognosis biomarker and a target for gene therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Effect Of Fam64a Expression On Chemoresistance and Lipid Dro...mentioning

confidence: 99%

FAM64A aggravates proliferation, invasion, lipid droplet formation, and chemoresistance in gastric cancer: A biomarker for aggressiveness and a gene therapy target

Yun

Yang

et al. 2023

Drug Development Research

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The promoting effects of GPR176 expression on proliferation, chemoresistance, lipogenesis and invasion of oesophageal cancer

Yun

Yin³

et al. 2023

J Cancer Res Clin Oncol

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Purpose As a member of the G-protein-coupled receptor 1 family, the G-protein-coupled receptor 176 (GPR176) gene encodes a glycosylated protein made up of 515 amino acids. The current study was performed to evaluate the impact of GPR176 on the clinicopathology and prognosis of oesophageal cancer, as well as uncover its molecular mechanisms. Methods Bioinformatics and clinical tissue samples were used to detect the expression and clinicopathological significance of GPR176 in oesophageal cancer. The expression, proliferation, migration and invasion, apoptosis and lipid droplet formation of GPR176 gene in oesophageal cancer were performed as phenotypic readouts. Results Here, RT-PCR and bioinformatic analyses revealed that GPR176 mRNA expression was significantly higher in oesophageal cancer than in normal mucosa (p < 0.05). GPR176 mRNA expression was associated with low weight and BMI, low T stage, low N and clinicopathological stage, low histological grade and favourable clinical outcome of oesophageal cancer (p < 0.05). The differential genes of GPR176 mRNA were involved in protein digestion and absorption, extracellular matrix constituent, endoplasmic reticulum lumen, among others (p < 0.05). GPR176-related genes were classified as being involved in oxidoreductase activity, actin and myosin complexes, lipid localisation and transport, among others (p < 0.05). GPR176 knockdown suppressed proliferation, anti-apoptotic and anti-pyroptotic properties, migration, invasion, chemoresistance and lipid droplet formation in oesophageal cancer cells (p < 0.05), while ACC1 and ACLY overexpression reversed the inhibitory effects of GPR176 silencing on lipid droplet formation and chemoresistance. Conclusion These findings indicated that upregulated expression of GPR176 might be involved in oesophageal carcinogenesis and subsequent progression, aggressiveness, and induced chemoresistance by ACC1- and ACLY-mediated lipogenesis and lipid droplet assembly.

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Regulatory mechanisms of the cAMP-responsive element binding protein 3 (CREB3) family in cancers

Yuxiong,

Faping,

Bin

et al. 2023

Biomedicine & Pharmacotherapy

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Synergistic regulation of hepatic Fsp27b expression by HNF4α and CREBH

Cited by 7 publications

References 21 publications

FAM64A aggravates proliferation, invasion, lipid droplet formation, and chemoresistance in gastric cancer: A biomarker for aggressiveness and a gene therapy target

FAM64A aggravates proliferation, invasion, lipid droplet formation, and chemoresistance in gastric cancer: A biomarker for aggressiveness and a gene therapy target

The promoting effects of GPR176 expression on proliferation, chemoresistance, lipogenesis and invasion of oesophageal cancer

Regulatory mechanisms of the cAMP-responsive element binding protein 3 (CREB3) family in cancers

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