Synergistic topical photoprotection by a combination of the iron chelator 2-furildioxime and sunscreen

Bissett, Donald; McBride, James F.

doi:10.1016/s0190-9622(96)90677-5

Cited by 38 publications

(21 citation statements)

References 12 publications

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“…Previous studies in hairless mice using iron-chelators and antioxidants indicate that UV-induced ROS are involved in photoaging (Bissett et al, 1990;Bissett and McBride, 1996). It has also been shown that exposure of human or mouse skin to UV irradiation upregulates the synthesis of the matrix-degrading enzymes matrix metalloproteinases (MMP), such as MMP-1, -2, -3, -7, -8, -9, and -12 (Fisher et al, , 2001Fisher and Voorhees, 1998;Saarialho-Kere et al, 1999;Inomata et al, 2003), which have been implicated in photoaging.…”

mentioning

confidence: 99%

Green Tea Polyphenols Prevent Ultraviolet Light-Induced Oxidative Damage and Matrix Metalloproteinases Expression in Mouse Skin

Vayalil

Mittal

Hara³

et al. 2004

Journal of Investigative Dermatology

244

175

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Chronic exposure of solar ultraviolet (UV) light to human skin results in photoaging. UV-induced oxidative damage and induction of matrix metalloproteinases (MMP) have been implicated in this process. Because polyphenols from green tea (GTP) prevent other cutaneous adverse effects of UV radiation we hypothesized that UV irradiation-induced oxidative damage and induction of MMP might be prevented in vivo in mouse skin by oral administration of GTP. GTP was administered in drinking water (0.2%, wt/vol) to SKH-1 hairless mice, which were then exposed to multiple doses of UVB (90 mJ per cm2, for 2 mo on alternate days) following in vivo photoaging animal protocol. Treatment of GTP resulted in inhibition of UVB-induced protein oxidation in vivo in mouse skin, a hallmark of photoaging, when analyzed biochemically, by immunoblotting, and immunohistochemistry. GTP treatment also inhibited UVB-induced protein oxidation in vitro in human skin fibroblast HS68 cells, which supports in vivo observations. Moreover, oral administration of GTP also resulted in inhibition of UVB-induced expression of matrix degrading MMP, such as MMP-2 (67%), MMP-3 (63%), MMP-7 (62%), and MMP-9 (60%) in hairless mouse skin. These data suggest that GTP as a dietary supplement could be useful to attenuate solar UVB light-induced premature skin aging.

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mentioning

confidence: 99%

Green Tea Polyphenols Prevent Ultraviolet Light-Induced Oxidative Damage and Matrix Metalloproteinases Expression in Mouse Skin

Vayalil

Mittal

Hara³

et al. 2004

Journal of Investigative Dermatology

244

175

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“…In this case, iron, by virtue of its ability to accept or donate electrons, acts as a prooxidant. Although this pathway has not been studied in the skin, it is interesting to note that iron may be released from hemoglobin after exposure to ultraviolet radiation during oxidative stress [77,78]. It is possible that the galvanic microparticles are mimicking these iron effects in the skin through production of free electrons and BMP/Smad canonical pathway activation.…”

Section: Resultsmentioning

confidence: 99%

Galvanic microparticles increase migration of human dermal fibroblasts in a wound-healing model via reactive oxygen species pathway

Tandon

Cimetta

Villasante

et al. 2014

Experimental Cell Research

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Electrical signals have been implied in many biological mechanisms, including wound healing, which has been associated with transient electrical currents not present in intact skin. One method to generate electrical signals similar to those naturally occurring in wounds is by supplementation of galvanic particles dispersed in a cream or gel. We constructed a three-layered model of skin consisting of human dermal fibroblasts in hydrogel (mimic of dermis), a hydrogel barrier layer (mimic of epidermis) and galvanic microparticles in hydrogel (mimic of a cream containing galvanic particles applied to skin). Using this model, we investigated the effects of the properties and amounts of Cu/Zn galvanic particles on adult human dermal fibroblasts in terms of the speed of wound closing and gene expression. The collected data suggest that the effects on wound closing are due to the ROS-mediated enhancement of fibroblast migration, which is in turn mediated by the BMP/SMAD signaling pathway. These results imply that topical low-grade electric currents via microparticles could enhance wound healing.

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“…FDO and sunscreen combination also can delay the onset of photocarcinogenesis and skin wrinkling in mice. 215 The photoprotective capacity of cadmium chloride-induced MT, an antioxidant, has been shown both in vivo and in vitro. It was found that MT-null mice, which are deficient in MT-1 and MT-2 genes, developed greater number of sunburn and apoptotic cells than those observed in normal mice on exposure to UVB radiation.…”

Section: Other Photoprotective Agentsmentioning

confidence: 99%

Photoprotection

Kullavanijaya

Lim

2005

Journal of the American Academy of Dermatology

345

265

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Synergistic topical photoprotection by a combination of the iron chelator 2-furildioxime and sunscreen

Cited by 38 publications

References 12 publications

Green Tea Polyphenols Prevent Ultraviolet Light-Induced Oxidative Damage and Matrix Metalloproteinases Expression in Mouse Skin

Green Tea Polyphenols Prevent Ultraviolet Light-Induced Oxidative Damage and Matrix Metalloproteinases Expression in Mouse Skin

Galvanic microparticles increase migration of human dermal fibroblasts in a wound-healing model via reactive oxygen species pathway

Photoprotection

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