Synergistic toxicity of ethanol and 2,4-dichlorophenoxyacetic acid enhances oxidant status, DNA damage, inflammation, and apoptosis in rats

İnce, Sinan; Demirel, Hasan Hüseyin; Zemheri‐Navruz, Fahriye; Arslan‐Acaröz, Damla; Küçükkurt, İ̇smail; Acaröz, Ulaş; Türeyen, Ali; Demirkapi, Ezgi Nur

doi:10.1007/s11356-022-22964-3

Cited by 9 publications

(4 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The decrease in antioxidant capacity was mainly shown by the reduction in the activity of hepatic antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), and glutathione reductase (GR) [ 62 , 64 , 75 ]. Among them, CAT ( n = 19, 46%), GST ( n = 16, 39%), and SOD ( n = 13, 31%) were the most frequently reported in the articles that investigated markers related to the antioxidant response.…”

Section: Resultsmentioning

confidence: 99%

“…However, when the production of free radicals exceeds the antioxidant capacity of the organism and reaches high concentrations, oxidative stress occurs, resulting in oxidative damage to cellular macromolecules, such as proteins, lipids, and nucleic acids [35,130]. The decrease in antioxidant capacity was mainly shown by the reduction in the activity of hepatic antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), and glutathione reductase (GR) [62,64,75]. Among them, CAT (n = 19, 46%), GST (n = 16, 39%), and SOD (n = 13, 31%) were the most frequently reported in the articles that investigated markers related to the antioxidant response.…”

Section: Toxicity Biomarkers 351 Antioxidant Metabolismmentioning

confidence: 99%

See 1 more Smart Citation

2,4-D Herbicide-Induced Hepatotoxicity: Unveiling Disrupted Liver Functions and Associated Biomarkers

Martins,

Carvalho,

Maia

et al. 2024

Toxics

View full text Add to dashboard Cite

2,4-dichlorophenoxyacetic acid (2,4-D) is a widely used herbicide worldwide and is frequently found in water samples. This knowledge has prompted studies on its effects on non-target organisms, revealing significant alterations to liver structure and function. In this review, we evaluated the literature on the hepatotoxicity of 2,4-D, focusing on morphological damages, toxicity biomarkers and affected liver functions. Searches were conducted on PubMed, Web of Science and Scopus and 83 articles were selected after curation. Among these studies, 72% used in vivo models and 30% used in vitro models. Additionally, 48% used the active ingredient, and 35% used commercial formulations in exposure experiments. The most affected biomarkers were related to a decrease in antioxidant capacity through alterations in the activities of catalase, superoxide dismutase and the levels of malondialdehyde. Changes in energy metabolism, lipids, liver function, and xenobiotic metabolism were also identified. Furthermore, studies about the effects of 2,4-D in mixtures with other pesticides were found, as well as hepatoprotection trials. The reviewed data indicate the essential role of reduction in antioxidant capacity and oxidative stress in 2,4-D-induced hepatotoxicity. However, the mechanism of action of the herbicide is still not fully understood and further research in this area is necessary.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Toxicity Biomarkers 351 Antioxidant Metabolismmentioning

confidence: 99%

2,4-D Herbicide-Induced Hepatotoxicity: Unveiling Disrupted Liver Functions and Associated Biomarkers

Martins,

Carvalho,

Maia

et al. 2024

Toxics

View full text Add to dashboard Cite

show abstract

“…The decrease in antioxidant capacity was mainly evidenced by the reduction in the activity of hepatic antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione Stransferase (GST), glutathione peroxidase (GPx), and glutathione reductase (GR) [51,53,64]. Among them, CAT (n=19, 46%), GST (n=16, 39%), and SOD (n= 13, 31%) were the most frequently reported in the articles that investigated markers related to the antioxidant response.…”

Section: Antioxidant Metabolismmentioning

confidence: 99%

2,4‐D Herbicide‐Induced Hepatotoxicity: Unveiling Disrupted Liver Functions and Associated Biomarkers

Martins,

Carvalho,

Maia

et al. 2023

Preprint

View full text Add to dashboard Cite

2,4-dichlorophenoxyacetic acid (2,4-D) is a globally used herbicide and is frequently found in water samples. This fact has prompted studies on its effects in non-target organisms, revealing significant alterations on liver structure and function. In this review, we evaluated the literature on the hepatotoxicity of 2,4-D, focusing on morphological damages, biomarkers of toxicity and affected liver functions. Searches were conducted on PubMed, Web of Science and Scopus and 83 articles were selected after curation. Among the studies, 72% used in vivo models and 30% used in vitro models. Additionally, 48% used the active ingredient, and 35% used commercial formu-lations in exposure experiments. The most affected biomarkers were related to a decrease in an-tioxidant capacity, including alterations in the activities of catalase and superoxide dismutase, and in the levels of malondialdehyde. Changes in energy metabolism, lipids, liver function, and xenobiotic metabolism were also identified. Furthermore, we found studies about the effects of 2,4-D in mixtures with other pesticides, as well as hepatoprotection trials. The reviewed data in-dicate that the reduction in antioxidant capacity and oxidative stress play an important role in 2,4-D-induced hepatotoxicity. However, the mechanism of action of the herbicide is still not ful-ly understood and further research in this area is needed.

show abstract

“… 18,19 Continuous exposure to DCP causes oxidative stress in hepatic tissues, contributing to an increase in kidney and renal problems. 20 These observed and documented problems serve as catalysts for modern nanotechnology research, which targets various methods of modifying nanomaterials, such as graphene, for the effective sensing and adsorption of various pollutants, which poses a great risk to plants and humans.…”

Section: Introductionmentioning

confidence: 99%

Computational modelling of graphene/aluminum nitride (GP/AlN) hybrid materials for the detection of 2,4 dichlorophenoxyacetic acid (DCP) pollutant

Apebende,

Amodu,

Ogbogu

et al. 2024

RSC Adv.

View full text Add to dashboard Cite

show abstract

Synergistic toxicity of ethanol and 2,4-dichlorophenoxyacetic acid enhances oxidant status, DNA damage, inflammation, and apoptosis in rats

Cited by 9 publications

References 49 publications

2,4-D Herbicide-Induced Hepatotoxicity: Unveiling Disrupted Liver Functions and Associated Biomarkers

2,4-D Herbicide-Induced Hepatotoxicity: Unveiling Disrupted Liver Functions and Associated Biomarkers

2,4‐D Herbicide‐Induced Hepatotoxicity: Unveiling Disrupted Liver Functions and Associated Biomarkers

Computational modelling of graphene/aluminum nitride (GP/AlN) hybrid materials for the detection of 2,4 dichlorophenoxyacetic acid (DCP) pollutant

Contact Info

Product

Resources

About