Synergistic treatment strategies to combat resistant bacterial infections using Schiff base modified nanoparticulate - hydrogel system

Bavya, M. C.; Rohan, K. Vimal; Gaurav, G.B.; Srivasatava, R.

doi:10.1016/j.msec.2018.10.080

Cited by 12 publications

(6 citation statements)

References 47 publications

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“…Biocides such as triclosan (irgasan) or fusidic acid have been used since 1998 for the successful removal of resistance plasmids in Gram-negative (E. coli) and Gram-positive (methicillin-resistant S. aureus) bacteria (Irish et al, 1998;Riber et al, 2016). Recently, nanoparticles have been proposed as potential tools to combat bacterial resistance (Jones et al, 2010;Bavya et al, 2019). An advantage of using nanoparticles is that they simultaneously target multiple structures, decreasing the risk of selecting/acquiring resistance to them (Zhang et al, 2010).…”

Section: Chemical Strategies For Removing Mgesmentioning

confidence: 99%

Targeting Plasmids to Limit Acquisition and Transmission of Antimicrobial Resistance

et al. 2020

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Antimicrobial resistance (AMR) is a significant global threat to both public health and the environment. The emergence and expansion of AMR is sustained by the enormous diversity and mobility of antimicrobial resistance genes (ARGs). Different mechanisms of horizontal gene transfer (HGT), including conjugation, transduction, and transformation, have facilitated the accumulation and dissemination of ARGs in Gram-negative and Gram-positive bacteria. This has resulted in the development of multidrug resistance in some bacteria. The most clinically significant ARGs are usually located on different mobile genetic elements (MGEs) that can move intracellularly (between the bacterial chromosome and plasmids) or intercellularly (within the same species or between different species or genera). Resistance plasmids play a central role both in HGT and as support elements for other MGEs, in which ARGs are assembled by transposition and recombination mechanisms. Considering the crucial role of MGEs in the acquisition and transmission of ARGs, a potential strategy to control AMR is to eliminate MGEs. This review discusses current progress on the development of chemical and biological approaches for the elimination of ARG carriers.

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Section: Chemical Strategies For Removing Mgesmentioning

confidence: 99%

Targeting Plasmids to Limit Acquisition and Transmission of Antimicrobial Resistance

et al. 2020

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“…Finally, the number of bacterial colonies on each agar plate was counted. The bacterial concentration in the group without the treatment of LS-GS and GS was used as a control …”

Section: Methodsmentioning

confidence: 99%

Green and Sustainable Self-Assembly Nanocomposite from Gentamicin Sulfate/Lignosulfonate with Efficient Antibacterial and Wound-Healing Activity

Zou

Bao

et al. 2020

ACS Sustainable Chem. Eng.

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In recent years, developments of drug delivery systems of antibiotics have been needed for improving antibacterial performance due to massive usage of antibiotics. With the global growing concept of being green, lignosulfonate (LS) has been deemed as an ecofriendly stabilizer and carrier that holds promise in preparing nanocomposites for antibacterial treatment. At the same time, LS and gentamicin sulfate (GS) have been proven to form a nanocomposite (LS-GS) with highly uniform size and roundness in solution. It also possesses a good loading capacity of GS. Density functional theory (DFT) verified that the interaction forces in LS-GS, a nanocomposite with selfassembly characteristics, were mainly combined via hydrogen bonds, van der Waals forces, and repulsion. The obtained LS-GS has the biocompatible, biodegradable, and low-cost merits of LS. It also exhibited excellent in vitro antibacterial activities against Escherichia coli and Staphylococcus aureus due to the antibacterial properties of GS. Moreover, an in-depth antibacterial study revealed the highly efficient antibacterial and woundhealing applications of LS-GS in vivo. Collectively, LS, a carrier material with low cost, which strikingly increases the antibacterial and wound-healing ability of GS in vitro and in vivo, will contribute to the production of large-scale antibacterial nanocomposites.

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“…Then the supernatant was collected and analysed for quantification of drug at 336 nm using UV spectrophotometer (Lambda 25, PerkinElmer). The percentage entrapment efficiency (EE) and loading efficiency (LE) were calculated using the following eqn (1) and (2) : 43 …”

Section: Methodsmentioning

confidence: 99%

“…It could be the fact that HA selectively binds to CD44 receptors overexpressed on the surface of MDA-MB-231 cells and are selectively uptaken through receptor-mediated endocytosis. 42,43 Previous literature reports have extensively compared different molecular weights of HA and concluded that high molecular weight HA exhibits increased CD44 receptor binding capacity than lower molecular weight HA. 53 Likewise, the high molecular weight of HA used in the study supports in improving the CD44 receptor binding capacity.…”

Section: Cellular Uptake and Quantication Studiesmentioning

confidence: 99%

Niclosamide encapsulated polymeric nanocarriers for targeted cancer therapy

et al. 2019

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Synergistic treatment strategies to combat resistant bacterial infections using Schiff base modified nanoparticulate - hydrogel system

Cited by 12 publications

References 47 publications

Targeting Plasmids to Limit Acquisition and Transmission of Antimicrobial Resistance

Targeting Plasmids to Limit Acquisition and Transmission of Antimicrobial Resistance

Green and Sustainable Self-Assembly Nanocomposite from Gentamicin Sulfate/Lignosulfonate with Efficient Antibacterial and Wound-Healing Activity

Niclosamide encapsulated polymeric nanocarriers for targeted cancer therapy

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