Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma

El-Hafeez, Amer Ali Abd; Fujimura, Takashi; Kamei, Rikiya; Hirakawa, Naoya; Baba, Kenji; Ono, Kazuhisa; Kawamoto, Seiji

doi:10.1007/s10616-017-0124-1

Cited by 12 publications

(5 citation statements)

References 28 publications

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“…Dasatinib, a tyrosine kinase inhibitor, has been approved for first-line treatment of chronic myelogenous leukemia [12]. Various ongoing studies are evaluating the effectiveness of dasatinib in different cancers [13][14][15][16], but the mechanisms underlying the effect of dasatinib on GC progression are not yet clear. Therefore, in this study, we analyzed how dasatinib suppresses the growth of GC cells and interacts with other chemotherapeutic drugs.…”

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confidence: 99%

Retracted: Dasatinib promotes TRAIL‐mediated apoptosis by upregulating CHOP‐dependent death receptor 5 in gastric cancer

Wang

Qin

et al. 2018

FEBS Open Bio

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Dasatinib, a tyrosine kinase inhibitor, has been approved for first‐line treatment of leukemia and has also been evaluated for use in numerous other cancers. However, its role in gastric cancer ( GC ) remains unclear. Therefore, the aim of this study was to investigate how dasatinib suppresses the growth of GC cells and interacts with chemotherapeutic drugs. The results showed that, in the presence of dasatinib, proliferation of GC cells decreased and apoptosis increased, and that Fas‐associated death domain protein and caspase‐8 are essential to dasatinib‐induced cell apoptosis in GC . In addition, we found that dasatinib increased the expression of death receptor 5 ( DR 5) in GC cells. Dasatinib enhanced apoptosis induced by tumor necrosis factor‐related apoptosis‐inducing ligand ( TRAIL ) in GC cells. Moreover, increased DR 5 expression facilitated dasatinib‐induced apoptosis; the dasatinib‐induced increase in DR 5 expression was mediated by CCAAT /enhancer‐binding protein homologous protein ( CHOP ). Furthermore, dasatinib also synergized with TRAIL to induce apoptosis via DR 5 in GC cells. Our results show that dasatinib promoted TRAIL ‐mediated apoptosis via upregulation of CHOP ‐dependent DR 5 expression in GC , suggesting that DR 5 induction can be used as an indicator of dasatinib sensitivity.

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mentioning

confidence: 99%

Retracted: Dasatinib promotes TRAIL‐mediated apoptosis by upregulating CHOP‐dependent death receptor 5 in gastric cancer

Wang

Qin

et al. 2018

FEBS Open Bio

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“…Previous studies have reported that PLE has anti-oxidative, anti-inflammatory, and antitumor effects [ 2 – 7 ]. Several studies have revealed the presence of anthocyanins, flavonoids, and phenolic acids in P. frutescens [ 3 , 8 – 11 ]. In addition, recent studies suggest that various compounds in PLE have anticancer activities.…”

Section: Discussionmentioning

confidence: 99%

Extracts of Perilla frutescens var. Acuta (Odash.) Kudo Leaves Have Antitumor Effects on Breast Cancer Cells by Suppressing YAP Activity

Kim

Shin

Choi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Yes-associated protein (YAP)/WW domain-containing transcription factor (TAZ) is critical for cell proliferation, survival, and self-renewal. It has been shown to play a crucial oncogenic role in many different types of tumors. In this study, we investigated the antitumor effect of the extracts of Perilla frutescens var. acuta (Odash.) Kudo leaves (PLE) on Hippo-YAP/TAZ signaling. PLE induced the phosphorylation of YAP/TAZ, thereby inhibiting their activity. In addition, the treatment suppresses YAP/TAZ transcriptional activity via the dissociation of the YAP/TAZ-TEAD complex. To elucidate the molecular mechanism of PLE in the regulation of YAP activity, we treated WT and cell lines with gene knockout (KO) for Hippo pathway components with PLE. The inhibitory effects of PLE on YAP-TEAD target genes were significantly attenuated in LATS1/2 KO cells. Moreover, we found the antitumor effect of PLE on MDA-MB-231 and BT549, both of which are triple-negative breast cancer (TNBC) cell lines. PLE reduced the viability of TNBC cells in a dose-dependent manner and induced cell apoptosis. Further, PLE inhibited the migration ability in MDA-MB-231 cells. This ability was weakened in YAP and TEAD-activated clones suggesting that the inhibition of migration by PLE is mainly achieved by regulating YAP activity. Taken together, the results of this study indicate that PLE suppressed cell growth and increased the apoptosis of breast cancer (BC) cells via inactivation of YAP activity in a LATS1/2-dependent manner.

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“…The synergistic anti-tumor effect was fulfilled by induction of cell cycle arrest at both G2/M and G1 phases. 102 The effects of PLE on two cancer cell lines, namely, HCT116 and H1299 (a colorectal cancer cell line and a LC cell line, respectively) were investigated. Treatment of these cells with PLE, dose-dependently inhibited cancer cells proliferation by 52-92% and completely abolished the colony formation in soft agar.…”

Section: Perilla Frutescensmentioning

confidence: 99%

Promising leads against lung cancer from the plants in Lamiaceae family

Rahimlouy Aghdam,

Hamedeyazdan

2024

Bioimpacts

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Introduction: Ceaselessly, management of cancer has been the major global challenge for healthcare professionals. As regards, lung cancer (LC) has been introduced as the second most common form of cancer in both men and women, taking the lives of more than a million people each year, statistically holding the highest mortality rate among all cancer types. Although much effort has been made for the management of LC, current therapies are quite ineffective. With reference to the fact that the most current chemotherapeutic agents for LC are of plant origin, the authors hereby collected the acclaimed plants from the Lamiaceae family which have shown remarkable activity against LC. Methods: The incorporated papers were published between the years of 1997 and 2023. The principal search keywords for this review article were "lung cancer", "Lamiaceae", "cytotoxic effect", "anti-tumor" and "anti-proliferative" in Medline, Springer, Scopus, ScienceDirect and Google Scholar databases. Results: To the furthest extent, different responsible mechanism(s) of action for the anti-cancer properties of each plant are discussed. The respected IC50 values for plant extracts, essential oils or pure isolated compounds are underlined as well. Conclusion: Many plants and isolated relative phytochemicals have shown exceptional anti-cancer potency against LC; nonetheless, they still remain undisclosed. We believe that this assembled data would globally inspire scientists on the passing way of LC treatment.

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Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma

Cited by 12 publications

References 28 publications

Retracted: Dasatinib promotes TRAIL‐mediated apoptosis by upregulating CHOP‐dependent death receptor 5 in gastric cancer

Retracted: Dasatinib promotes TRAIL‐mediated apoptosis by upregulating CHOP‐dependent death receptor 5 in gastric cancer

Extracts of Perilla frutescens var. Acuta (Odash.) Kudo Leaves Have Antitumor Effects on Breast Cancer Cells by Suppressing YAP Activity

Promising leads against lung cancer from the plants in Lamiaceae family

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