Synergistic use of biomaterials and licensed therapeutics to manipulate bone remodelling and promote non-union fracture repair

Simpson, Christopher R.; Kelly, Helena; Murphy, Ciara M.

doi:10.1016/j.addr.2020.10.011

Cited by 28 publications

(23 citation statements)

References 300 publications

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“…Their extra-cellular matrix, which consists of water, minerals (e.g., hydroxyapatite, calcium fluoride, and calcium carbonate), and proteins (mostly type I collagen) [ 17 ], undergoes constant remodeling. Equilibrium is obtained by synthesizing osteoblasts and degradation from osteoclasts [ 3 ]. bmMSCs influence this through their secretome and their ability to develop into osteoblasts [ 3 , 18 ].…”

Section: Bone Regenerationmentioning

confidence: 99%

“…Equilibrium is obtained by synthesizing osteoblasts and degradation from osteoclasts [ 3 ]. bmMSCs influence this through their secretome and their ability to develop into osteoblasts [ 3 , 18 ].…”

Section: Bone Regenerationmentioning

confidence: 99%

“…Furthermore, macrophage deficient mice have fewer MSCs in their bones, decrease bone mineralization and longer fracture healing time [ 22 ]. On the other hand, a high and prolonged inflammatory intensity impairs, or even completely inhibits, the tissue healing process [ 3 ].…”

Section: Bone Regenerationmentioning

confidence: 99%

“…In young healthy patients, bone tissue shows high self-repair abilities. However, systematic factors, such as an increased age, disease or obesity can negatively affect bone regeneration [ 1 , 2 , 3 ]. Large defects due to heavy trauma, multiple fracture, infection, or tumor resection, are also disruptive for proper tissue healing [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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The Role of Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering

Mende

Götzl

Kubo

et al. 2021

Cells

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Bone regeneration is a complex process that is influenced by tissue interactions, inflammatory responses, and progenitor cells. Diseases, lifestyle, or multiple trauma can disturb fracture healing, which might result in prolonged healing duration or even failure. The current gold standard therapy in these cases are bone grafts. However, they are associated with several disadvantages, e.g., donor site morbidity and availability of appropriate material. Bone tissue engineering has been proposed as a promising alternative. The success of bone-tissue engineering depends on the administered cells, osteogenic differentiation, and secretome. Different stem cell types offer advantages and drawbacks in this field, while adipose-derived stem or stromal cells (ASCs) are in particular promising. They show high osteogenic potential, osteoinductive ability, and immunomodulation properties. Furthermore, they can be harvested through a noninvasive process in high numbers. ASCs can be induced into osteogenic lineage through bioactive molecules, i.e., growth factors and cytokines. Moreover, their secretome, in particular extracellular vesicles, has been linked to fracture healing. The aim of this review is a comprehensive overview of ASCs for bone regeneration and bone tissue engineering.

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Section: Bone Regenerationmentioning

confidence: 99%

Section: Bone Regenerationmentioning

confidence: 99%

Section: Bone Regenerationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Role of Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering

Mende

Götzl

Kubo

et al. 2021

Cells

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show abstract

“…Despite the outcomes of biomaterials for bone repair, many issues still hinder the clinical transformation from several aspects. For example, the clinical indications are limited, the majority of biomaterials are used as bone void fillers for implant fixation and only a few of them can be used in non-union fractures [ 33 ]. In addition, biocompatibility is another concern.…”

Section: Introductionmentioning

confidence: 99%

Implantable blood clot loaded with BMP-2 for regulation of osteoimmunology and enhancement of bone repair

Fan

Bai

Shan

et al. 2021

Bioactive Materials

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The treatment of large-area bone defects still faces many difficulties and challenges. Here, we developed a blood clot delivery platform loaded with BMP-2 protein (BMP-2@BC) for enhanced bone regeneration. Blood clot gel platform as natural biomaterials can be engineered from autologous blood. Once implanted into the large bone defect site, it can be used for BMP-2 local delivery, as well as modulating osteoimmunology by recruiting a great number of macrophages and regulating their polarization at different stages. Moreover, due to the deep-red color of blood clot gel, mild localized hyperthermia under laser irradiation further accelerated bone repair and regeneration. We find that the immune niche within the bone defect microenvironment can be modulated in a controllable manner by the blood clots implantation and laser treatment. We further demonstrate that the newly formed bone covered almost 95% of the skull defect area by our strategy in both mice and rat disease models. Due to the great biocompatibility, photothermal potential, and osteoimmunomodulation capacity, such technology shows great promise to be used in further clinical translation.

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Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration

Shariati,

Bedar,

Huang

et al. 2024

Advanced Therapeutics

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Tissue regeneration involves dynamic dialogue between and among different cells and their surrounding matrices. Bone regeneration is specifically governed by reciprocity between osteoblasts and osteoclasts within the bone microenvironment. Osteoclast‐directed resorption and osteoblast‐directed formation of bone are essential to bone remodeling, and the crosstalk between these cells is vital to curating a sequence of events that culminate in the creation of bone tissue. Among bone biomaterial strategies, many have investigated the use of different material cues to direct the development and activity of osteoblasts. However, less attention has been given to exploring features that similarly target osteoclast formation and activity, with even fewer strategies demonstrating or integrating biomaterial‐directed modulation of osteoblast‐osteoclast coupling. This review aims to describe various biomaterial cues demonstrated to influence osteoclastogenesis and osteoclast function, emphasizing those that enhance a material construct's ability to achieve bone healing and regeneration. Additionally discussed are approaches that influence the communication between osteoclasts and osteoblasts, particularly in a manner that takes advantage of their coupling. Deepening the understanding of how biomaterial cues may dictate osteoclast differentiation, function, and influence on the microenvironment may enable the realization of bone‐replacement interventions with enhanced integrative and regenerative capacities.

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Synergistic use of biomaterials and licensed therapeutics to manipulate bone remodelling and promote non-union fracture repair

Cited by 28 publications

References 300 publications

The Role of Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering

The Role of Adipose Stem Cells in Bone Regeneration and Bone Tissue Engineering

Implantable blood clot loaded with BMP-2 for regulation of osteoimmunology and enhancement of bone repair

Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration

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