Synergy of BMI and family history on diabetes: the Humboldt Study

Chen, Yue; Rennie, Donna; Dosman, James A.

doi:10.1017/s1368980009991285

Cited by 13 publications

(9 citation statements)

References 33 publications

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“…However, BMI may also be influenced by genes indicating the possibility that also gene-gene interactions may contribute to our findings. The observation of an interaction between a parental history of diabetes and obesity concurs with results from a Canadian study, also cross-sectional in its design, suggesting that the combination of high BMI and a family history of diabetes increases the risk to develop diabetes [17]. However, the analyses were performed on men and women combined.…”

Section: Discussionsupporting

confidence: 80%

“…Analyses of interactions between family history and different environmental factors may thus identify environmental factors that if combined with a genetic susceptibility are particularly hazardous with regard to diabetes. Only a few earlier studies have evaluated interaction effects for the combination of family history of diabetes and presence of risk factors related to lifestyle and results are divergent [12], [17].…”

Section: Introductionmentioning

confidence: 99%

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The Risk of Type 2 Diabetes in Men Is Synergistically Affected by Parental History of Diabetes and Overweight

et al. 2013

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Interactions between genetic- and lifestyle factors may be of specific importance for the development of type 2 diabetes. Only a few earlier studies have evaluated interaction effects for the combination of family history of diabetes and presence of risk factors related to lifestyle. We explored whether 60-year-old men and women from Stockholm with a parental history of diabetes are more susceptible than their counterparts without a parental history of diabetes to the negative influence from physical inactivity, overweight or smoking regarding risk of developing type 2 diabetes. The study comprised 4232 participants of which 205 men and 113 women had diabetes (the vast majority type 2 diabetes considering the age of study participants) and 224 men and 115 women had prediabetes (fasting glucose 6.1–6.9 mmol/l). Prevalence odds ratios (OR) with 95% confidence intervals (95% CI) were calculated using logistic regression. Biologic interaction was analyzed using a Synergy index (S) score. The crude OR for type 2 diabetes associated with a parental history of diabetes was 2.4 (95% CI 1.7–3.5) in men and 1.4 (95% CI 0.9–2.3) in women. Adjustments for overweight, physical inactivity and current smoking had minimal effects on the association observed in men whereas in women it attenuated results. In men, but not in women, a significant interaction effect that synergistically increases the risk of developing type 2 diabetes was observed for the combination of BMI>30 and a parental history of diabetes, S 2.4 (95% CI 1.1–5.1). No signs of interactions were noted for a parental history of diabetes combined with physical inactivity and smoking, respectively. In conclusion, obesity in combination with presence of a parental history of diabetes may be particularly hazardous in men as these two factors were observed to synergistically increase the risk of developing type 2 diabetes in men.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

The Risk of Type 2 Diabetes in Men Is Synergistically Affected by Parental History of Diabetes and Overweight

et al. 2013

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“…These results, which need to be replicated in different samples, extend previous research showing that additional risk factors such as obesity work interactively with parental history of diabetes (8, 9, 11) to influence risk for type 2 diabetes. Current etiological understanding of diabetes suggests that underlying genetic risk is compounded by other factors until clinical threshold is reached (4).…”

Section: Discussionsupporting

confidence: 80%

Parental History of Diabetes, Positive Affect, and Diabetes Risk in Adults: Findings from MIDUS

Tsenkova

Karlamangla²,

Ryff

2016

ann. behav. med.

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Background Family history of diabetes is one of the major risk factors for diabetes but significant variability in this association remains unexplained, suggesting the presence of important effect modifiers. Purpose To our knowledge, no previous work has examined whether psychological factors moderate the degree to which family history of diabetes increases diabetes risk. Methods We investigated the relationships among parental history of diabetes, affective states (positive affect, negative affect, and depressed affect), and diabetes in 978 adults from the MIDUS 2 national sample. Results As expected, parental history of diabetes was associated with an almost threefold increase in diabetes risk. We found a significant interaction between positive affect and parental history of diabetes on diabetes (p=.009): higher positive affect was associated with a statistically significant lower relative risk for diabetes in participants who reported having a parental history of diabetes (RR=.66 per unit increase in positive affect; 95% CI: .47; .93), but it did not influence diabetes risk for participants who reported no parental history of diabetes (p=.34). This pattern persisted after adjusting for an extensive set of health and sociodemographic covariates and was independent of negative and depressed affect. Conclusions These results suggest that psychological well-being may protect individuals at increased risk from developing diabetes. Understanding such interactions between non-modifiable risk factors and modifiable psychological resources is important for delineating biopsychosocial pathways to diabetes and informing theory-based, patient-centered interventions to prevent the development of diabetes.

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“…In our study, we found a joint effect of FHD and abdominal obesity on IFG. Consistently, studies from Canadian and Finnish populations have shown joint effects of family history and obesity on diabetes [24,23]. Adjusted for age, sex, region, marital status, education level, occupation, smoking, drinking, physical activity, sleep quality, and history of hypertension.…”

Section: Discussionmentioning

confidence: 67%

“…The MONICA/KORA Augsburg cohort study reported an additive effect of overall and abdominal obesity on diabetes [22]. Joint effects of genetic risk scores and obesity had been reported to have contributed to the risk of diabetes [23,24]. Abdominal obesity was classified as waist circumference ≥85 cm for men and ≥80 cm for women.…”

Section: Discussionmentioning

confidence: 99%

Interaction of poor sleep quality, family history of type 2 diabetes, and abdominal obesity on impaired fasting glucose: a population-based cross-sectional survey in China

Qin

Lou

Chen

et al. 2015

Int J Diabetes Dev Ctries

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This study aims to explore the interaction of sleep quality, family history of type 2 diabetes, and obesity in relation to impaired fasting glucose in a Chinese population. A representative population-based cross-sectional study was conducted, and 15,145 residents aged between 18 and 75 years were selected from 11 districts of Xuzhou City, Jiangsu Province. The Pittsburgh Sleep Quality Index was used to evaluate sleep conditions, with categories of good and poor. Impaired fasting glucose (IFG) was assessed by fasting blood glucose. Interaction of sleep quality, obesity, and family history of diabetes (FHD) on IFG was analyzed by logistic regression. Relative excess risk due to interaction (RERI) and the synergy index (SI) were applied to evaluate the additive interaction between the two factors. Either poor sleep or positive FHD was independently associated with an increased odds ratio (OR) for IFG. Those with both poor sleep and positive FHD had a significantly increased risk compared with those without poor sleep and FHD (OR 20.6, 95 % confidence interval (CI) 16.4-29.0, P<0.001). The corresponding RERI and SI was 14.6 (8.6-20.6) and 3.7 (1.4-5.1), respectively. Both abdominal obesity and FHD significantly increased the risk of being IFG. The synergistic effect of abdominal obesity and FHD on IFG was statistically significant (OR 40.1, 95 % CI 28.8-61.5). The results suggest that additive interactions exist between poor sleep quality, abdominal obesity, and family history of diabetes in relation to impaired fasting glucose.

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Synergy of BMI and family history on diabetes: the Humboldt Study

Cited by 13 publications

References 33 publications

The Risk of Type 2 Diabetes in Men Is Synergistically Affected by Parental History of Diabetes and Overweight

The Risk of Type 2 Diabetes in Men Is Synergistically Affected by Parental History of Diabetes and Overweight

Parental History of Diabetes, Positive Affect, and Diabetes Risk in Adults: Findings from MIDUS

Interaction of poor sleep quality, family history of type 2 diabetes, and abdominal obesity on impaired fasting glucose: a population-based cross-sectional survey in China

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