Synergy of Hofmeister effect and ligand crosslinking enabled the facile fabrication of super-strong, pre-stretching-enhanced gelatin-based hydrogels

Zeng, Cheng; Wu, Pengxi; Guo, Jinglun; Zhao, Nan; Ke, Cheng; Liu, Guoqiang; Zhou, Feng; Liu, Weimin

doi:10.1039/d2sm01158a

Cited by 5 publications

(2 citation statements)

References 42 publications

(46 reference statements)

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“…The chemical composition of hydrogels, such as the type and concentration of crosslinking agents, can affect their cycle life and fatigue properties. Hydrogels with a higher degree of physical cross-linking typically have a higher cycle life and fatigue resistance [ 227 ]. On the other hand, hydrogels with a higher water content are generally more susceptible to fatigue damage than those with lower water content.…”

Section: Hweb Propertiesmentioning

confidence: 99%

Electrochemical Wearable Biosensors and Bioelectronic Devices Based on Hydrogels: Mechanical Properties and Electrochemical Behavior

Saeidi,

Chenani,

Orouji

et al. 2023

Biosensors

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Hydrogel-based wearable electrochemical biosensors (HWEBs) are emerging biomedical devices that have recently received immense interest. The exceptional properties of HWEBs include excellent biocompatibility with hydrophilic nature, high porosity, tailorable permeability, the capability of reliable and accurate detection of disease biomarkers, suitable device–human interface, facile adjustability, and stimuli responsive to the nanofiller materials. Although the biomimetic three-dimensional hydrogels can immobilize bioreceptors, such as enzymes and aptamers, without any loss in their activities. However, most HWEBs suffer from low mechanical strength and electrical conductivity. Many studies have been performed on emerging electroactive nanofillers, including biomacromolecules, carbon-based materials, and inorganic and organic nanomaterials, to tackle these issues. Non-conductive hydrogels and even conductive hydrogels may be modified by nanofillers, as well as redox species. All these modifications have led to the design and development of efficient nanocomposites as electrochemical biosensors. In this review, both conductive-based and non-conductive-based hydrogels derived from natural and synthetic polymers are systematically reviewed. The main synthesis methods and characterization techniques are addressed. The mechanical properties and electrochemical behavior of HWEBs are discussed in detail. Finally, the prospects and potential applications of HWEBs in biosensing, healthcare monitoring, and clinical diagnostics are highlighted.

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Section: Hweb Propertiesmentioning

confidence: 99%

Electrochemical Wearable Biosensors and Bioelectronic Devices Based on Hydrogels: Mechanical Properties and Electrochemical Behavior

Saeidi,

Chenani,

Orouji

et al. 2023

Biosensors

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show abstract

“…The role of the Hofmeister effect is generally considered to be based on the strong hydration of the Hofmeister series of kosmotropic ions, by immersing pristine protein hydrogels in specific solutions to obtain hydrogels with high strength and toughness. Zeng et al 19 introduced ligand cross-linking and hydrogen bonding to create ultrahigh-strength gelatin-based hydrogels. Utilizing the Hofmeister effect allowed for selfstrengthening through prestretching, offering ionic stimulus response and shape restoration capabilities.…”

Section: Introductionmentioning

confidence: 99%

Breathable Gelatin Conductive Hydrogels Using a Template Method and Reverse Use of Hofmeister Effect for Wearable Sensors

Ma,

Xu,

Chen

et al. 2024

ACS Appl. Polym. Mater.

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Hydrogel-based wearable sensing devices are attractive and have broad application prospects on motion intention recognition and health monitoring. The research on the aspect of their wearable comfort and the improvement of breathability is essential. In this paper, a breathable porous hydrogel film was prepared using a template method combined with the inverse Hofmeister effect. Different from conventional hydrogels that utilize the Hofmeister effect by using lyophilic ions for toughening, our approach involved the reverse application of the Hofmeister effect, the use of chaotropic ions, which induced a loosening effect within the hydrogel interior, thereby achieving a more uniform pore distribution. The prepared hydrogel film has excellent mechanical properties (elongation at break of 404%, tensile strength of 173 kPa), air permeability (9.96 mg·cm–2·h–1), and sensitivity (GF = 4.41). The film is used as a wearable sensor with high sensitivity and accuracy to monitor human finger, wrist, and large joint movements, human electrophysiological signals [electromyogram (EMG) and electrocardiogram (ECG)], small changes in vocal cord vibration, and manipulation of electronic devices for gaming. This work provides an approach for the preparation of breathable hydrogel films as wearable sensors.

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Acid-mediated strategies designed for stretchable and durable polyacrylamide/sodium alginate dual-network hydrogels toward flexible capacitors and wearable sensors

Li,

Wei,

Xing

et al. 2024

International Journal of Biological Macromolecules

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Synergy of Hofmeister effect and ligand crosslinking enabled the facile fabrication of super-strong, pre-stretching-enhanced gelatin-based hydrogels

Abstract: Hydrogels are becoming increasingly popular in biomedical and soft machine manufacturing, but their practical application is limited by poor mechanical properties. In recent years, Hofmeister effect-enhanced gelatin hydrogels have become...

Cited by 5 publications

References 42 publications

Electrochemical Wearable Biosensors and Bioelectronic Devices Based on Hydrogels: Mechanical Properties and Electrochemical Behavior

Electrochemical Wearable Biosensors and Bioelectronic Devices Based on Hydrogels: Mechanical Properties and Electrochemical Behavior

Breathable Gelatin Conductive Hydrogels Using a Template Method and Reverse Use of Hofmeister Effect for Wearable Sensors

Acid-mediated strategies designed for stretchable and durable polyacrylamide/sodium alginate dual-network hydrogels toward flexible capacitors and wearable sensors

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