Synovial fluid cytokines and proteinases as markers of temporomandibular joint disease

Kubota, Eiro; Kubota, Takao; Matsumoto, Jun; Shibata, Takanori; Murakami, Ken-Ichiro

doi:10.1016/s0278-2391(98)90868-0

Cited by 216 publications

(132 citation statements)

References 20 publications

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“…6 Further studies showed that IL-6 is one of the most important pro-inflammatory cytokines that contribute to the pathogenesis of internal derangement in the TMJ. [6][7][8] Sato et al 9 detected the substance in nearly 50% of the synovial tissue specimen taken from TMJs with internal derangement. Other chemical mediators like a new peptide such as substance p and serotonin have also been detected in the TMJs and are thought to contribute to internal derangement.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of oral and parafunctional habits in Nigerian patients suffering temporomandibular joint pain and dysfunction

Saheeb¹

2009

Journal of Medicine and Biomedical Research

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Pain and dysfunction of the temporo-mandibular joint (TMJ) still pose a therapeutic dilemma to the oral and maxillofacial surgeon. Epidemiological data on the disorder in Nigerians appear not to be available, as only few studies are recorded.1 Studies from North America revealed a prevalence rate of 12.1% amongst adults, 2 although some authors have claimed that pain, clicking and locking have been experienced by approximately 20% of the general population. Pain in the joint and muscles is often distressing to patients. Advances in research in this area have thrown more light on the probable causes of the pain. The concept of inflammatory changes in the joint synovium, capsule or retrodiscal tissues as the principal underlying cause of pain has been documented. 4 Large quantities of inflammatory mediators of pain were identified in the synovial fluid of Prevalence of oral and parafunctional habits in Nigerian patients suffering temporomandibular joint pain and dysfunction BDO Saheeb ABSTRACTThis study was conducted to determine the prevalence of oral and parafunctional habits in Nigerian patients suffering temporomandibular joint pain and dysfunction. It consisted of patients that were referred for treatment at the oral and maxillofacial surgery clinic of the University of Benin Teaching Hospital, Benin City, Nigeria. A pre-designed data form was used to collect information on age, gender, reasons for attendance, joint pain, side of pain, clicking, oral habits known to patient, parafunctional habits, occlusion and dietary habits. A total of 29 patients comprising 48.3% male and 51.7% female in a male to female ratio of 1:1.1 were studied. Their age ranged from 17 to 70 years. Eighty two per cent of them complained of joint pain on presentation while 17.1% complained of muscle pain. The joint pain was mainly unilateral in 62.1% and bilateral in 20.7%. Twenty six (89.7%) patients indulged in oral and parafunctional habits such as unilateral mastication 65.5%, hand-on-chin posture 58.6%, clenching 17.2%, tooth grinding 13.8%, chewing gum 37.9%, and finger and nail biting 24.1%. In all, 31.0% of males and 34.5% of females had clicking joints. Reciprocal click was detected in 52.6% of the study sample. There was a prevalence of 89.7% of oral and parafunctional habits in Nigerian patients suffering temporomandibular joint pain and dysfunction.

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Section: Introductionmentioning

confidence: 99%

Prevalence of oral and parafunctional habits in Nigerian patients suffering temporomandibular joint pain and dysfunction

Saheeb¹

2009

Journal of Medicine and Biomedical Research

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“…In osteoarthritis, the expression of MMP-9 mRNA and protein is increased in articular cartilage and isolated chondrocytes (24.51.71). Such increased expression in the articular chondrocytes may contribute to the increased MMP-9 activity in the joint fluid of human patients with osteoarthritis (41) and in that of horses with ascptic joint disease (13).…”

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confidence: 99%

Biomechanical regulation of matrix metalloproteinase‐9 in cultured chondrocytes

Jin

Sah

et al. 2000

Journal Orthopaedic Research

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Summary:Abnormal mechanical loading of joints may induce degeneration of articular cartilage. Shear stress is one mode of mechanical loading that may regulate chondrocyte metabolism. We investigated the mechanism by which shear stress induccs the gene encoding matrix metalloproteinase-9, a mediator of the progressive degradation of articular cartilage in ostcoarthritis. In vifro experiments using passaged rabbit chondrocytes in monolayer culture subjected to a shear stress of 16 dynicn? (1.6 Pa) in a flow channel showed increased expression of the matrix mctalloproteinase-9 gcne. The induction of matrix metalloproteinase-9 appeared to depend on a region in the 5' promoter of the gcnc that contains a 12-0-tetradecanoylphorbol 13-acetateresponsive element. Transfection experiments using a construct containing a luciferase reporter driven by a 12-0-tetradecanoylphorbol 13-acetate-responsive clement indicated that shear stress activated a 12-0-tetradecanoylphorbol 13-acetate-responsive element-mediated transcription in chondrocytes. Similar experiments showed that shear stress induced a matrix metalloproteinase-9 promoter construct (matrix metalloproteinase-9-luciferase). Shear stress activated c-Jun NH1-terniinal kinasc, cxtraccllular signal-regulated kinase. and p3X. 'Transfection of matrix inetalloproteinase-9-lucifcrase together with thc dominant negative mutant of c-.Tun NH,-terminal kinase. hut not with that of cxtraccllular signal-regulated kinase or p38. attenuated the shearinduced matrix metalloproteinasc-9 promoter activity. In addition. transfection of constructs encoding dominant negative mutants o C Ras. Rac. and Cdc42 attenuated the induction of c-Jun transcriptional activity by shear stress. Thus. shear stimulation of chondrocytes stimulates Kas, Rac, and Cdc42, which subsequcntly activate c-Jun NH?-terminal kinasc to induce a 12-0-tetradecanoylphorhol 13-acetate-responsive clementmcdiatcd expression of matrix metalloproteinase-9. ~The metabolic activity of chondrocytes is regulated by mechanical factors (28). Such biomechanical regulation map affect the balance between anabolic and catabolic processes in articular cartilage. In osteoarthritis, a metabolic imbalance results in lie1 matrix degradation and the degeneration of articular cartilage (59). Many in vivo and in vitro studies have examined the effect of biomechanical stimuli on the synthesis of matrix proteins by chondrocytes (28). However. relatively few studies have analyzed the extracellular or cellular mechanisms by which mechanical stimuli may alter cartilage matrix degradationincluding the modulation of matrix protcinascs and their inhibitors (68)-and thereby contribute to the initiation or progression of osteoarthritis.In osteoarthritis, the synthesis of matrix metalloprotcinascs (MMPs) by chondrocytes is incrcased (20) and the balancc betwcen proteases and protease

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“…Furthermore, synovial fluid was reported to show quantitative and qualitative changes in response change in the TMJ 17) . A biochemical analysis revealed that various components in synovial fluid were related to pain 8,24) . One study reported that the release or activation of matrix metalloproteinases and collagenases in fibroblasts and chondrocytes in tissues are involved when regressive changes in the synovial membrane are present.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Signal Intensity from Retrodiscal Tissue Related to Joint Effusion Status and Disc Displacement in Elderly Patients with Temporomandibular Joint Disorders

Ohkubo

Sano

Otonari-Yamamoto

et al. 2009

Bull. Tokyo Dent. Coll.

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Magnetic resonance imaging (MRI) on patients with temporomandibular joint disorders (TMD) has revealed that a decrease and/or increase in signal intensity from retrodiscal tissue, joint effusion (the excessive accumulation of joint fluid) and articular disc displacement are related to TMD. However, the effect of aging on these phenomena has yet to be clarified. This study was carried out to explore the relationship between changes in signal intensity from retrodiscal tissue, joint fluid status and pathological disc conditions in elderly patients with TMD. Twenty patients aged over 60 years were examined. They consisted of one man and 19 women, and ranged between 60 and 79 years in age (mean, 66.0 years). The relationships between decreased signal intensity on proton-density-weighted (PDW) images and increased signal intensity on T2-weighted (T2W) MR images from retrodiscal tissue, joint fluid status and state of articular disc were examined. Joint fluid status was classified into 5 levels by extent of high signal areas in upper and lower articular spaces on T2W images. Disc displacement status was evaluated by PDW images. The Wilcoxon test was applied for the statistical analysis. The group showing increased T2W signal intensities from the retrodiscal tissue consisted of 31 out of 40 joints (77.5%). This group showed a significant difference in comparison with the other groups in which no apparent joint fluid was shown (pϽ0.05). There were no statistically significant differences among other categories. The results suggest a negative relationship between joint fluid and increased signal intensity from retrodiscal tissue due to reflection of the inflammatory reaction in TM joints.

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Synovial fluid cytokines and proteinases as markers of temporomandibular joint disease

Cited by 216 publications

References 20 publications

Prevalence of oral and parafunctional habits in Nigerian patients suffering temporomandibular joint pain and dysfunction

Prevalence of oral and parafunctional habits in Nigerian patients suffering temporomandibular joint pain and dysfunction

Biomechanical regulation of matrix metalloproteinase‐9 in cultured chondrocytes

Magnetic Resonance Signal Intensity from Retrodiscal Tissue Related to Joint Effusion Status and Disc Displacement in Elderly Patients with Temporomandibular Joint Disorders

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