Synovial immunopathology in haemochromatosis arthropathy

Abstract

The histological picture of the synovium in HH arthropathy largely resembles a process reminiscent of OA. Neutrophil invasion is, however, markedly increased in HH arthropathy, especially in joints with iron deposition. Accumulation of neutrophils may be crucial for the production of matrix enzymes, which enables cartilage degradation and more rapidly progressive articular damage.

Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stress

“…The total area of hemosiderin deposits in the synovial membrane was measured as previously described [7]. Measurements were made using a semi-automatic image analysis software (ImageJ v1.49).…”

Characteristics of the arthropathy described in hereditary hemochromatosis

“…In the synovium, deposits of iron have been observed, particularly in the synovial lining cells (6,7,(31)(32)(33). Indeed, deposition here as opposed to in the sublining layers or synovial stroma differentiates between HH and secondary forms of hemochromatosis, such as occurs in thalassemia major (34).…”

“…Deposition may be effectively irreversible and accompanied by slowly progressive chondral resorption, even in subjects who undergo regular venesection (12,32). Iron deposition may itself be seriously detrimental to the joint.…”

Role of Interleukin 1 in the Development of Human Diseases

“…Тем не менее в другом исследовании было показано, что мАТ к ИЛ1Р (AMG108) оказались эффективными у части пациентов с ОА коленного сустава [193], что связывают с их более мощ-ным и длительным подавлением биологических эффектов ИЛ1 по сравнению с анакинрой. Предполагается также, что ИЛ1 играет более важную роль при некоторых субтипах ОА, например связанном с гемохроматозом [194,195].…”