Synovial inflammation in arthroscopically obtained biopsy specimens from the temporomandibular joint: A review of the literature and a proposed histologic grading system

Gynther, Göran; Dijkgraaf, Leonore C; Reinholt, Finn P.; Holmlund, Anders; Liem, Rsb; Bont, Lambert G.M. de

doi:10.1016/s0278-2391(98)90609-7

Cited by 62 publications

(47 citation statements)

References 16 publications

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“…Some studies have graded the number of cell layers and reported its proliferation on TMJs showing disc displacement, osteoarthritis, and following induced trauma. [8][9][10] Laser phototherapy (LPT) is an option for the treatment of musculoskeletal disorders due to its analgesic, antiinflammatory and regenerative effects. 11 This therapy has been used on TMDs and showed good patient acceptance and reduction of the use of drugs.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Laser Phototherapy in the Inflammatory Process of the Rat's TMJ Induced by Carrageenan

Carvalho

Lacerda

Neto

et al. 2011

Photomedicine and Laser Surgery

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Section: Introductionmentioning

confidence: 99%

Evaluation of Laser Phototherapy in the Inflammatory Process of the Rat's TMJ Induced by Carrageenan

Carvalho

Lacerda

Neto

et al. 2011

Photomedicine and Laser Surgery

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“…24,25 Synovial hyperplasia, vasucularity and an increase in inflammatory cells are all characteristic changes brought about by synovitis. 14,15 In an arthroscopic study, Segami et al 17 investigated whether JE indicated the presence of synovitis by comparing amounts of JE and degree of synovitis. They found that joints with effusion had more pronounced synovitis than joints with no effusion, and, moreover, amount of 8 JE increased according to severity of synovitis.…”

Section: Discussionmentioning

confidence: 99%

“…13 Furthermore, microscopic investigation revealed that JE may reflect synovitis. 14,15 Gynther et al 16 found that the inflammatory changes brought about by synovitis in the TMJ induced hyperplasia of the synovial cell layer. Segami et al 17 suggested that there was a strong correlation between hyperplastic synovial tissue and amount of JE.…”

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confidence: 99%

Potential of fluid-attenuated inversion recovery (FLAIR) in identification of temporomandibular joint effusion compared with T2-weighted images

Imoto

Otonari-Yamamoto

Nishikawa

et al. 2011

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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Objective. The purpose of this study was to determine the potential of fluid attenuated inversion recovery (FLAIR) sequence images in the identification of joint effusion (JE) in comparison with T2-weighted images.Study design. A total of 31 joints (28 patients) with JE were investigated by magnetic resonance imaging. Regions of interest were placed over JE, cerebrospinal fluid (CSF) and gray matter (GM) on T2-weighted and FLAIR images and their signal intensities compared. The signal intensity ratios (SIRs) of JE and CSF were calculated used GM as the reference point. The Pearson product-moment correlation coefficient was used for the statistical analysis.Result. The SIR of JE showed a strong correlation between T2-weighted and FLAIR images. However, no correlation was observed for CSF. The average suppression ratio for JE was lower than that for CSF. According to the inclusion and exclusion criteria (Table I), 201 joints were excluded from this study. A total of 31 joints of 28 patients were studied. A total of 31 joints of 28 patients were studied. There were 4 males and 24 females. The mean age of the patients was 39.9 years with an age range of 13 to 76 years. ConclusionAll images were obtained with the 1. The signal intensity ratio (SIR)s of JE and CSF were calculated as follows: SIR = the signal intensity of JE or CSF/the signal intensity of GM. In the FLAIR sequence images, the patients were divided into Group A (TE, 122 ms) and Group B (TE, 168 ms) for the statistical analysis. The Pearson product-moment correlation coefficient was used to assess the correlation between the SIRs on the T2-weighted and FLAIR images of both JE and CSF. A probability of less than 0.05 was considered statistically significant. The suppression ratios of the signal intensities in FLAIR imaging were also compared according to the following equation: (SIR of T2-weighted imagesSIR of FLAIR images)/SIR of T2-weighted images × 100 (Figure 3). 6 ResultsThe SIRs obtained for JE and CSF on T2-weighted and FLAIR images are shown in Table III. The average SIR of JE was higher than that of CSF on both T2-weighted and FLAIR images in both Groups A and B.A strong correlation between T2-weighted images and FLAIR images was obtained for JE in both groups. The correlation coefficient was 0.81 in Group A and 0.94 in Group B (Figures 4 and 5). On the other hand, no correlation was found between the two sets of images for CSF (0.09 in Group A、-0.33 in Group B).The average suppression ratio for the signal intensity of JE by FLAIR imaging was 36.9% in Group A and 16.3% in Group B. The ratio for CSF was 75.6% in Group A and 71.7% in Group B (Table IV). The signal intensity of CSF was suppressed more markedly than that of JE.7 DiscussionJoint effusion is considered to be a pathological collection of joint fluid that can only be observed on T2-weighted images. Hitherto, the only way to determine the presence of JE has been by amount of fluid present in the joint. We hypothesized that the FLAIR technique would provide additional inform...

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“…Several studies have also indicated that an increased level of IL-1β in the synovial fluid is associated with pain and hyperalgesia in the TMJ (6,7). The condition (known as synovitis) often accompanies DD/ID and OA of the TMJ and is characterized by chronic inflammatory changes, including hyperplasia of the synovial lining (8,9), growth of small new blood vessels (9) and infiltration of inflammatory cells (9)(10)(11). Synovial fibroblasts are a major source of the mediators of joint inflammation.…”

Section: Introductionmentioning

confidence: 99%

“…In this study, we performed DNA microarray analysis to search for differentially expressed genes under the notion that they could provide diagnostic and therapeutic markers for pathogeneInt J Oral-Med Sci 12(1): [5][6][7][8][9][10][11][12]2013sis and lead to new treatments for IL-1β-related diseases. In addition, we performed a pathway analysis of microarray data to investigate the key functions and signaling pathways involved in inflammation and joint destruction.…”

Section: Introductionmentioning

confidence: 99%

Microarray Analysis Detection of Signaling Pathway Responsive to IL-1β in Synovial Fibroblasts from TMJ

Kishida

Ogura

2013

Int J Oral-Med Sci

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Interleukin-1β (IL-1β) has important roles in the inflammation and connective tissue destruction observed in joint diseases such as rheumatoid arthritis. IL-1β is also a key mediator of intracapsular pathologic conditions of the temporomandibular joint (TMJ), including disk displacement/internal derangement and osteoarthritis. To identify putative IL-1β-responsive genes from arthritic disease tissues, gene expression of IL-1β treated and untreated synovial fibroblasts was measured using DNA microarray, and IL-1β-responsive genes were analyzed with GeneSpring. To measure the expression of 8,793 genes in synovial fibroblasts from five TMJ patients, significant changes between controls and IL-1β-treated cells (p < 0.05) were detected in 170 genes; 139 up-regulated genes, and 31 down-regulated genes. In addition, the biological interactions of IL-1β-regulated genes were investigated using Ingenuity Pathway Analysis, and it was found that IL-1β affects the expression of several genes in the NFκB signaling pathway. NFKB1 gene expression increased in synovial fibroblasts by IL-1β treatment. Gene expression of IKBa, TNFAIP3 and TNIP1, which are negative-feedback regulators, were also increased after IL-1β treatment in synovial fibroblasts. The increase in the expression of these genes was confirmed by real time-PCR analysis. The results suggest that IL-1β-responsive genes play important roles in the progression of inflammation and destruction of joint components.

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Synovial inflammation in arthroscopically obtained biopsy specimens from the temporomandibular joint: A review of the literature and a proposed histologic grading system

Cited by 62 publications

References 16 publications

Evaluation of Laser Phototherapy in the Inflammatory Process of the Rat's TMJ Induced by Carrageenan

Evaluation of Laser Phototherapy in the Inflammatory Process of the Rat's TMJ Induced by Carrageenan

Potential of fluid-attenuated inversion recovery (FLAIR) in identification of temporomandibular joint effusion compared with T2-weighted images

Microarray Analysis Detection of Signaling Pathway Responsive to IL-1β in Synovial Fibroblasts from TMJ

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