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Background. Synovial sarcoma is a rarely encountered soft tissue sarcoma. Surgery with a wide surgical margin is the treatment of choice. However, there is no consensus on the treatment of head and neck synovial sarcoma in patients with cervical metastasis.Methods. A 20-year-old man was seen with a palpable mass in the right neck. He had been diagnosed with synovial sarcoma of the right tonsil and treated by surgery 1 and a half years before; therefore, the mass detected was thought to be a cervical metastasis of synovial sarcoma. We performed a modified radical neck dissection with no postoperative treatment. The pathological diagnosis was confirmed by detecting the SSspecific fusion gene SYT-SSX1.Results. The patient remains free of recurrence or metastasis 2 years and 10 months after the surgery.Conclusions. We encountered a case of head and neck synovial sarcoma with cervical metastasis that was successfully treated. V
Background. Synovial sarcoma is a rarely encountered soft tissue sarcoma. Surgery with a wide surgical margin is the treatment of choice. However, there is no consensus on the treatment of head and neck synovial sarcoma in patients with cervical metastasis.Methods. A 20-year-old man was seen with a palpable mass in the right neck. He had been diagnosed with synovial sarcoma of the right tonsil and treated by surgery 1 and a half years before; therefore, the mass detected was thought to be a cervical metastasis of synovial sarcoma. We performed a modified radical neck dissection with no postoperative treatment. The pathological diagnosis was confirmed by detecting the SSspecific fusion gene SYT-SSX1.Results. The patient remains free of recurrence or metastasis 2 years and 10 months after the surgery.Conclusions. We encountered a case of head and neck synovial sarcoma with cervical metastasis that was successfully treated. V
Synovial sarcoma is a malignant mesenchymal neoplasm, most commonly occurring near the joints of the extremities. Its occurrence in the neck is less common. Surgical excision is the first choice of treatment, postoperative radiotherapy and chemotherapy are often required to reduce the risk of recurrence. The size of the malignancy is one of the indicators for prognosis, primary lesions of 5 cm or greater in diameter usually give rise to poorer outcomes [3] . Here, we report a case of massive recurrent synovial sarcoma in the neck which was successfully resected following embolization of the supplying arteries to the tumor. Case reportA 25-year-old female was admitted to our hospital complaining of a gigantic mass in the left cervical area. The mass was recurring. A resection was performed on the mass 6 years ago in the local hospital and a subsequent recurrence was resected 4 years later. It recurred again last year, developed rapidly and was painful. Percutaneous needle biopsy revealed a synovial sarcoma. On admission, physical examination showed a 30 × 28 cm welldefined mass occupying the entire left cervical region. There were petechiae on the surface of the skin overlying the mass with a cutaneous ulceration in the center. Compression of the trachea and oesophagus caused both dyspnea and dysphagia (Fig. 1).Needle biopsy (gauge 20) was repeated to confirm the histological diagnosis of synovial cell sarcoma. No metastatic lesions were found in the lungs on radiological examination. Digital subtraction angiography (DSA) was performed on the left common carotid and subclavian arteries revealing the left external carotid and subclavian arteries as supplying vessels to the tumor. All supplying branches of those arteries were successfully embolized in order to shrink the tumor preoperatively (Fig. 2, 3). Subsequently the tumor was resected along with the left thyroid. The tumor, which measured 15 × 16 × 11 cm, had well-defined smooth margins adjacent to the trachea, oesophagus and the left recurrent laryngeal nerve. The left external carotid vein was invaded by the tumor, which was careful dissected. The left common carotid artery was wrapped in the tumor mass, which was peeled and preserved because the option to replace the artery was not available. As the result, the mass weighing 2.5 kg was completely resected (Fig. 4). The patient was discharged accordingly after recovery from the surgery. The inpatient time was 15 days, during which no sequelae were noticed. Pathological examination revealed biphasic morphology consisting of glandular structures and spindle cells (Fig. 5, 6) with no calcifications. DiscussionSynovial sarcoma accounts for 5%-10% of all soft tissue sarcomas [7, 9] . More than 80% of cases occur in the extremities. The head and neck region is a rare (3%-9%) but a known location [2, 9] . This patient's age is typical for Abstract We report a rare case of massive recurrent synovial sarcoma of the neck in a 25-year-old woman. Physical examination showed a 30 × 28 cm well-defined subcutaneous mass ...
Synovial sarcoma generally is associated with poor prognosis. With recent advances in molecular biology, it has become apparent not all synovial sarcomas share the same tumor biology. 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) is useful for risk assessment in several types of sarcomas. We therefore assessed the clinical value of 18 F-FDG-PET-derived maximum standard uptake value (SUV max ) for predicting survival in patients with synovial sarcoma. 18 F-FDG-PET was performed in 44 patients with synovial sarcoma before therapy and resection. SUV max was calculated for each tumor and then evaluated for prognostic usefulness along with metastasis at presentation, tumor grade, histopathologic subtype, age, gender, postsurgical margins, anatomic location, and tumor size for overall survival and progression-free survival. SUV max ranged from 1.2 to 13.0 (median, 4.35). Pretherapy tumor SUV max predicted overall survival and progression-free survival. Patients presenting with a SUV max greater than 4.35 had a decreased diseasefree survival and were therefore at high risk for having local recurrences and metastatic disease.
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