Synovial sarcoma: A rare tumor of larynx

Poor outcome of comprehensive therapy in a case of laryngeal synovial sarcoma

“…No recurrences or metastases occurred, and the longest survival time was 16 years 15. Chemo/radiotherapy also seemed to be useful in the treatment of distant metastases and local recurrence 10,14. Some reports had a very short follow-up period (<2 years), and the exact outcomes require a further investigation 2,4–6,9,11,13.…”

Synovial sarcoma presenting as a parotid mass: Case report and review of literature

“…There is limited literature on the appropriate therapy for head and neck synovial sarcoma due to the low incidence in this site. Surgery followed by radiotherapy has been advocated by most,4–9, 18, 25 and chemotherapy with ifosfamide has been tried in some cases 25, 26. However, most studies support a primary role for surgery and do not advocate use of chemotherapy or radiotherapy as the sole treatment modality 3, 15.…”

Submucosal neoplasms of the laryngeal introitus

“…Laryngeal synovial cell sarcomas represented a relatively large proportion of malignant submucosal tumours in this series (four out of 22), but only a handful of cases are discussed in the literature. 15,16 These aggressive malignancies arise from pluripotent mesenchymal progenitor synovial cells (which exist in the soft tissues of the anterior larynx, particularly the thyrohyoid ligament) and much less frequently from the synovial lining of joints within the head and neck. Around 200 synovial cell sarcomas involving various sites within the head and neck (with deep neck soft tissues slightly more commonly involved than aerodigestive tract) have been described since the first report in 1954, 16 but a literature search revealed only 15 previously described cases in the larynx.…”