Synovial sarcoma of the head and neck

Bukachevsky, Roman; Pincus, Robert; Shechtman, Frank G.; Sarti, E; Chodosh, Paul L.

doi:10.1002/hed.2880140110

Cited by 95 publications

(76 citation statements)

References 11 publications

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“…The disease is more common in men than women with a 3:2 ratio [1][2][3][4][5][6][7][8][9][10][11][12][13]. The histology of sarcomas is complex and immunohistochemical analysis is often required to differentiate one subtype from another.…”

Section: Expert Commentarymentioning

confidence: 99%

Treatment outcomes for patients with synovial sarcoma of the head and neck

Lee¹,

Shin²

2008

Expert Review of Anticancer Therapy

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Evaluation of: Harb WJ, Luna MA, Patel SR, Ballo MT, Roberts DB, Sturgis EM. Survival in patients with synovial sarcoma of the head and neck: association with tumor location, size, and extension. Head Neck 29, 731-740 (2007). Synovial sarcoma of the head and neck occurs most commonly in males in their third decade of life. Synovial sarcoma of the head is rare, accounting for less than 10% of all head and neck sarcomas. Due to its rarity, there are very few publications on the treatment approach for these tumors. However, it is uniformly accepted that all head and neck synovial sarcomas should undergo complete surgical resection followed by postoperative radiation therapy in those at high risk for locoregional recurrence. In terms of chemotherapy, there are also emerging data on its effectiveness in the treatment of synovial sarcoma of the head and neck. The paper under evaluation reports a single institution's 36-year experience on the treatment of synovial sarcoma of the head and neck. This paper highlights the importance of a multidisciplinary approach in the treatment of this disease.

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Section: Expert Commentarymentioning

confidence: 99%

Treatment outcomes for patients with synovial sarcoma of the head and neck

Lee¹,

Shin²

2008

Expert Review of Anticancer Therapy

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“…Although these tumors occur mostly in the extremities, they are also known to arise in the head and neck region [6,7,10]. The first description of a head and neck synovial sarcoma of hypopharynx was given by Jernstrom [9] in 1954.…”

Section: Discussionmentioning

confidence: 99%

“…The neoplasm often originates in proximity to the major joints, particularly the lower limbs, while other localizations, such as the retroperitoneum [2], pleura, lung [3,4], thorax and mediastinum [5] are unusual sites. Synovial sarcoma of head and neck are very rare and account for only 3% to 9% of all sarcomas [6,7]. The first case of synovial sarcoma of the neck was reported by Jernstrom in 1954 [8][9][10] since then only about 85 cases have been reported [6,8].…”

Section: Introductionmentioning

confidence: 99%

“…Synovial sarcoma of head and neck are very rare and account for only 3% to 9% of all sarcomas [6,7]. The first case of synovial sarcoma of the neck was reported by Jernstrom in 1954 [8][9][10] since then only about 85 cases have been reported [6,8]. Two different histological types have been identified and are generally referred to as the classic biphasic type which is composed of epithelial cells and a spindle cell with a growth pattern which may be either glandular or solid, and a monophasic type in which a single cellular component is dominant; furthermore, other histological types of synovial sarcoma exist which are poorly differentiated and have a much lower incidence.…”

Section: Introductionmentioning

confidence: 99%

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Synovial Sarcoma of the Head and Neck: a Report of 2 Cases

Nath¹,

Gupta²,

Sp³

et al. 2016

JCR

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Abstract:Synovial sarcoma is a rare malignant tumor which arises from a mesenchymal precursor stem cell that is unrelated to mature synovial tissue. Synovial sarcoma mostly affects extremities usually lower limbs between the ages of 15 and 40 years and the proportion of male-to-female patients is 3:2. It is very rare in the head and neck region especially in laryngopharynx. Till date, only six cases of synovial sarcoma involving laryngopharynx have been reported in the literature. Painless mass, hoarseness, upper respiratory distress, and dysphagia characterize the original complaints in laryngopharyngeal synovial sarcoma. Because head and neck synovial sarcoma in clinical practice is so uncommon, early diagnosis is difficult and the treatment protocol is unclear. The authors report two rare cases of synovial sarcoma of head and neck. First case was synovial sarcoma of larynx was treated by complete excision via the laryngofissure approach followed by radiotherapy. There has been no recurrence after 2 years of the complete excision and serial punch biopsies have come out to be negative. The second case is synovial sarcoma of the parotid treated by radiotherapy.

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“…In theory, the greatest significance of chemotherapy is prevention and/or postponement of the occurrence of distant metastases, although this opinion has not been proved yet [25].…”

Section: Discussionmentioning

confidence: 99%

Synovial sarcoma of carotid space

et al. 2012

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AbstractSynovial sarcomas are malignant tumors of mesenchymal origin, extremely rarely located in the area of the head and neck. Histologically they can be monophasic, biphasic or poorly differentiated with numerous differential diagnostic dilemmas. A 54-year-old male with synovial sarcoma of the carotid space is presented. The patient refused suggested postoperative radiotherapy and, nine months after the primary surgery, local relapse was verified. Following surgical resection of the local relapse, postoperative radiotherapy treatment was utilized. Ten months after the second surgery, secondary deposits in the lungs were radiographically confirmed, and local recurrence was noticed again. Treatment was continued with symptomatic therapy and eleven months later patient died. Synovial sarcomas of the carotid space are extremely rare, with complex surgical approaches and pathohistological differential diagnostic dilemmas. Diagnosis requires determination of the immunophenotype of the tumor cells, whereas therapy requires an aggressive surgical approach and postoperative radiotherapy.

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Synovial sarcoma of the head and neck

Cited by 95 publications

References 11 publications

Treatment outcomes for patients with synovial sarcoma of the head and neck

Treatment outcomes for patients with synovial sarcoma of the head and neck

Synovial Sarcoma of the Head and Neck: a Report of 2 Cases

Synovial sarcoma of carotid space

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