Synovial sarcoma of the hypopharynx – a case report and literature review

Kamhieh, Yasmine; Fox, Hannah; Holland, P; Passant, C

doi:10.1016/j.bjorl.2016.04.001

Cited by 6 publications

(8 citation statements)

References 7 publications

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“…CT is useful for evaluation of airway compromise and compression. Lymph node invasion in head and neck SS is seen in CT in 12.5% of cases [8] , [9] . There is no correlation between imaging and histological findings [8] , [9] .…”

Section: Discussionmentioning

confidence: 98%

“…Lymph node invasion in head and neck SS is seen in CT in 12.5% of cases [8] , [9] . There is no correlation between imaging and histological findings [8] , [9] . On the other hand, immunohistochemistry of synovial sarcomas is complex and unique, it includes mesenchymal markers expression such as vimentin and epithelial markers as cytokeratins 19 and 7 and epithelial membrane antigen that are presented in 90% of all cases [4] , [5] , [10] , [11] , [12] .…”

Section: Discussionmentioning

confidence: 98%

“…Consequently, symptoms will depend on mass effect over adjacent structures and may range from mild throat discomfort, hoarseness to dysphagia and dyspnea [2] , [5] . SS are multinodular masses that may vary diameter from 1 to 15 cm [5] , [7] , [8] , they can be classified into monophasic or biphasic. Monophasic synovial sarcomas (MSS) can be epithelial, poor differentiated, calcified, and mixed due to their histological characteristics [4] , [5] .…”

Section: Discussionmentioning

confidence: 99%

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Biphasic synovial sarcoma of the hypopharynx: Case report and literature review

Girón

Rodríguez

Rey

et al. 2022

International Journal of Surgery Case Reports

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Introduction Synovial Sarcoma is a rare malignancy that accounts between 8 and 10% of soft tissue neoplasms, with the highest presentation rate in extremities, an extremely uncommon condition in head and neck. Clinical findings We present a case of an 18-year-old male with synovial sarcoma situated at hypopharynx who underwent surgical resection and postoperative radiotherapy. Conclusion Synovial Sarcoma represents a rare head and neck malignancy with challenging diagnostic approach due to its frequency and nonspecific clinical manifestations. Surgical treatment must assure good free margins. Adjuvant radiotherapy has a positive impact in local recurrence and survival.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Biphasic synovial sarcoma of the hypopharynx: Case report and literature review

Girón

Rodríguez

Rey

et al. 2022

International Journal of Surgery Case Reports

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“…Synovial sarcoma is a primitive mesenchymal malignant tumor with a poor prognosis that frequently occurs in adolescents and young adults [3]. It generally arises near joints, but it can develop in unexpected locations such as the head and neck, heart, kidney, lung, and abdomen, which can result in a preoperative misdiagnosis [4][5][6][7]. In the head and neck region, it most commonly occurs in the hypopharynx, but it can also occur in the prevertebral, parapharyngeal, laryngeal, and maxillofacial areas [8,9].…”

Section: Discussionmentioning

confidence: 99%

Primary pharyngeal synovial sarcoma in a pediatric patient: A case report

Bae

Kim

Cha

et al. 2021

Preprint

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BackgroundSynovial sarcoma is a rare malignant tumor that typically originates from the soft tissue of the extremities. The occurrence of primary pharyngeal synovial sarcoma (PPSS) is even rarer, and few studies have reported its radiological features. Here, we report a case of pediatric PPSS and describe the conventional and advanced magnetic resonance imaging (MRI) findings with pathologic correlation.Case presentationAn 11-year-old girl presented to the otolaryngologic clinic with dysphagia. Laryngoscopy revealed a large mass in the oropharynx. MRI revealed a well-defined soft tissue mass with a maximal diameter of approximately 5 cm originating from the submucosal space of the oropharynx. The mass was primarily solid and showed homogeneous contrast-enhancement. The mass was hypointense on T1-weighted images and hyperintense on T2-weighted images. The mass showed a homogeneously low apparent diffusion coefficient value on diffusion-weighted imaging, which indicated high tumor cellularity. Dynamic contrast-enhanced MRI revealed a hypovascular tumor with low values of the volume transfer constant between the extracellular extravascular space and blood plasma and blood plasma volume per unit tissue volume. Amide proton transfer-weighted MRI revealed a relatively high amide proton transfer signal in the tumor, indicating a high protein/peptide component. The patient underwent surgical resection of the tumor, and the diagnosis of biphasic synovial sarcoma was confirmed on postoperative pathological examination. The patient was started on chemotherapy with vincristine, ifosfamide, doxorubicin, and etoposide, and the patient is still under follow-up.ConclusionSynovial sarcoma should be considered in the differential diagnosis of pediatric oropharyngeal submucosal tumors. Multimodal MRI may aid diagnosis, although the final diagnosis should be based on the postoperative pathological examination findings.

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“…Synovial sarcoma is a primitive mesenchymal malignant tumor with a poor prognosis that frequently occurs in adolescents and young adults [3] . It generally arises near joints, but it can develop in unexpected locations such as the head and neck, heart, kidney, lung, and abdomen, which can result in a pre-operative misdiagnosis [4–7] . In the head and neck region, it most commonly occurs in the hypopharynx, but it can also occur in the prevertebral, parapharyngeal, laryngeal, and maxillofacial areas [8,9] .…”

Section: Discussionmentioning

confidence: 99%

Primary pharyngeal synovial sarcoma in a pediatric patient

et al. 2021

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Rationale: Synovial sarcoma is a rare malignant tumor that typically originates from the soft tissue of the extremities. The occurrence of primary pharyngeal synovial sarcoma is even rarer, and few studies have reported its radiological features. Here, we report a case of pediatric primary pharyngeal synovial sarcoma and describe the conventional and advanced magnetic resonance imaging (MRI) findings with pathologic correlation. Patient concerns: An 11-year-old girl presented to the otolaryngologic clinic with dysphagia. Diagnosis: Laryngoscopy revealed a large mass in the oropharynx. MRI revealed a well-defined soft tissue mass with a maximal diameter of approximately 5 cm originating from the submucosal space of the oropharynx. The mass was primarily solid and showed homogeneous contrast-enhancement. The mass was hypointense on T1-weighted images and hyperintense on T2-weighted images. The mass showed a homogeneously low apparent diffusion coefficient value on diffusion-weighted imaging, which indicated high tumor cellularity. Dynamic contrast-enhanced MRI revealed a hypovascular tumor with low values of the volume transfer constant between the extracellular extravascular space and blood plasma and blood plasma volume per unit tissue volume. Amide proton transfer-weighted MRI revealed a relatively high amide proton transfer signal in the tumor, indicating a high protein/peptide component. The patient underwent partial surgical resection of the tumor, and the diagnosis of biphasic synovial sarcoma was confirmed on postoperative pathological examination. Intervention: The patient was started on chemotherapy with vincristine, ifosfamide, doxorubicin, and etoposide. Outcomes: The tumor did not respond to the 3 cycles of the chemotherapy. Thus, the patient underwent second surgery and subsequent radiation therapy. The patient is now under ifosfamide/carboplatin/etoposide chemotherapy. Lesson: Synovial sarcoma should be considered in the differential diagnosis of pediatric oropharyngeal submucosal tumors. Multimodal MRI may aid diagnosis, although the final diagnosis should be based on the postoperative pathological examination findings.

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Synovial sarcoma of the hypopharynx – a case report and literature review

Cited by 6 publications

References 7 publications

Biphasic synovial sarcoma of the hypopharynx: Case report and literature review

Biphasic synovial sarcoma of the hypopharynx: Case report and literature review

Primary pharyngeal synovial sarcoma in a pediatric patient: A case report

Primary pharyngeal synovial sarcoma in a pediatric patient

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