Synovial sarcoma of the larynx in a 79-year-old woman, confirmed by karyotyping and fluorescence in situ hybridization analysis

Mhawech‐Fauceglia, Paulette; Ramzy, Peter; Bshara, Wiam; Sait, Sheila; Rigual, Néstor R.

doi:10.1016/j.anndiagpath.2006.02.007

Cited by 9 publications

(5 citation statements)

References 14 publications

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“…Chemo/radiotherapy also seemed to be useful in the treatment of distant metastases and local recurrence 10,14. Some reports had a very short follow-up period (<2 years), and the exact outcomes require a further investigation 2,4–6,9,11,13. Although our case involved multiple therapeutic strategies, including surgery, radiotherapy, repeated chemotherapies, and targeted therapies, the outcome was poor.…”

Section: Discussionmentioning

confidence: 81%

“…Of the 17 patients for whom data were available2–7,9–18, 16 (94.1%) had tumour located in the supraglottic and 1 (5.9%) had tumour in the subglottis; no patient had tumour in the glottis area. For the 16 patients for whom follow-up data were available, the follow-up times ranged from 3 months to 16 years 2–6,8–11,13–18. Of these 16 patients, only four (including our patient) developed recurrence and three developed distant metastases.…”

Section: Discussionmentioning

confidence: 99%

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Poor outcome of comprehensive therapy in a case of laryngeal synovial sarcoma

Bao¹,

Wang²,

Zhou³

et al. 2013

Radiology and Oncology

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BackgroundSynovial sarcoma is common in the extremities. Our search revealed only 17 cases of synovial sarcoma of the larynx in the English-language literature.Case reportWe report an additional case of a 37-year-old man with primary laryngeal synovial sarcoma who underwent positron emission tomography/computed tomography (PET/CT) following the treatment. Although the patient received comprehensive therapy including surgery, radiotherapy, repeated chemotherapies, and targeted therapies, he had an unfavourable outcome and died of distant metastases.ConclusionsIn synovial sarcoma of the larynx, PET/CT can detect recurrence and metastasis. PET/CT can also predict the treatment effect in patients with synovial sarcoma.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Poor outcome of comprehensive therapy in a case of laryngeal synovial sarcoma

Bao¹,

Wang²,

Zhou³

et al. 2013

Radiology and Oncology

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“…To the best of our knowledge, ours is only the fourth case of laryngeal synovial sarcoma to feature a demonstration of t(X;18) by karyotyping, and only the second to do so by the FISH methodology. 21,25,27 Based on our review of the literature, the treatment of choice for laryngeal synovial sarcoma is surgery. According to reports of other rare laryngeal tumors, conservation surgery has been shown to provide as much local control as radical surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors in the United States have argued that these tumors should always be treated without organ preservation surgery. 22,27 However, these opinions were based on single cases with little follow-up; no objective evidence for such a strategy exists. The introduction of CO 2 laser surgery for the management of laryngeal synovial sarcomas has shown some promise in terms of local control in cases with followups ranging from 15 months to 3 years.…”

Section: Discussionmentioning

confidence: 99%

Synovial Sarcoma of the Larynx Treated by Supraglottic Laryngectomy: Case Report and Literature Review

Luna-Ortiz

Cano-Valdez²,

Cunha

et al. 2013

Ear Nose Throat J

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We describe a case of synovial sarcoma of the larynx, and we discuss the use of fluorescence in situ hybridization (FISH) in confirming the diagnosis. The patient was a 21-year-old woman who presented with a recurrence of a previously resected supraglottic tumor of the aryepiglottic folds. A horizontal supraglottic laryngectomy was performed, and the 0.5-cm tumor was resected. Histopathologic study suggested that it was a biphasic malignant tumor compatible with a synovial sarcoma. The diagnosis of synovial sarcoma was confirmed by FISH immunohistochemistry with the use of an SYT break-apart probe. The patient recovered satisfactorily, but at follow-up 5 years and 4 months later, tumoral activity was evident in the left side of the neck. A biopsy found that 5 lymph nodes contained a metastasis of the synovial sarcoma. Again, a bilateral neck dissection was performed, and it revealed that 16 of 16 right-side nodes and 36 of 36 left-side nodes were negative. Two months later, the patient received 46 Gy of radiotherapy in 23 sessions. She remained free of disease during 2 more years of follow-up. Synovial sarcoma of the larynx is a rare entity. Organ preservation seems to be indicated in these cases. The histologic diagnosis may be difficult. In this case, the identification of a genetic mutation corroborated the diagnosis.

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“…20-22 Of laryngeal sarcomas, chondrosarcoma is the most common, but other types such as leiomyosarcoma, rhabdomyosarcoma, osteosarcoma, liposarcoma, and synovial sarcoma, have also been described. 23-29 Sarcomas of the larynx may develop in any portion of the organ. Similar to carcinomas, however, they tend to originate in the vocal cords where they usually present as a painless submucosal mass.…”

Section: Discussionmentioning

confidence: 99%

Low-Grade Myofibroblastic Sarcoma of the Larynx

Covello¹,

Licci

Pichi³

et al. 2011

Int J Surg Pathol

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Low-grade myofibroblastic sarcoma is an uncommon sarcoma with myofibroblastic differentiation. It occurs in a wide variety of sites and has a predilection for the head and neck region. Biologically, low-grade myofibroblastic sarcoma has a propensity for local recurrence and is associated with a low risk of metastatic spread. Histologically, it can mimic a variety of different types of benign and malignant processes and often requires immunohistochemical analysis for its accurate identification. This report describes a case and discusses the differential diagnosis of a low-grade myofibroblastic sarcoma that arose in the larynx of a 69-year-old woman with a history of metastatic skin melanoma. To the best of the authors' knowledge this is the first description in the English literature of low-grade myofibroblastic sarcoma originating in the larynx.

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Synovial sarcoma of the larynx in a 79-year-old woman, confirmed by karyotyping and fluorescence in situ hybridization analysis

Cited by 9 publications

References 14 publications

Poor outcome of comprehensive therapy in a case of laryngeal synovial sarcoma

Poor outcome of comprehensive therapy in a case of laryngeal synovial sarcoma

Synovial Sarcoma of the Larynx Treated by Supraglottic Laryngectomy: Case Report and Literature Review

Low-Grade Myofibroblastic Sarcoma of the Larynx

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