Synovial sarcoma with t(X:18) chromosomal translocation, cardiac involvement, and peripheral embolus

Hall, Thomas C.; Jensen, Dag A.; Lohse, James R.; Shokeir, M. Omar

doi:10.1002/(sici)1096-911x(199902)32:2<141::aid-mpo13>3.0.co;2-n

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Cardiac metastasis of synovial sarcoma is reported in a few cases in the literature. To our knowledge, none of these were from primary laryngeal synovial sarcoma 4–10. A 2021 review of laryngeal synovial sarcomas found 39 total cases in the literature prior to 2018, five of which had local disease recurrence, as with this case, and two with metastasis, but neither with cardiac metastasis 1.…”

Section: Discussionmentioning

confidence: 78%

Cardiogenic and obstructive shock: primary laryngeal synovial sarcoma with cardiac metastasis

Matthews,

Salman,

Mustafa

et al. 2023

BMJ Case Rep

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A man in his 20s with a history of laryngeal synovial sarcoma presented with dyspnoea. Imaging revealed a large right ventricular (RV) mass, which was resected, and histological analysis indicated synovial sarcoma recurrence. Within 1 month of RV mass resection, the tumour progressed with paratracheal metastasis. The lumen was nearly obliterated, and right ventricular outflow tract (RVOT) obstruction led to rapid deterioration with mixed cardiogenic and obstructive shock. We present a rare case of primary laryngeal synovial sarcoma metastasising to the heart.

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Section: Discussionmentioning

confidence: 78%

Cardiogenic and obstructive shock: primary laryngeal synovial sarcoma with cardiac metastasis

Matthews,

Salman,

Mustafa

et al. 2023

BMJ Case Rep

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“…At radiologic analysis, synovial sarcomas typi cally manifest as heterogeneous masses that occa sionally contain calcium (42). At MR imaging, these tumors demonstrate heterogeneous signal intensity on T1-and T2-weighted images and may have fluid-fluid levels due to hemorrhage and necrosis within cystic components of the tumor (43).…”

Section: Synovial Sarcomamentioning

confidence: 99%

Primary Thoracic Sarcomas

Gladish¹,

Sabloff²,

Munden³

et al. 2002

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170

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Primary sarcomas of the thorax are rare. The diagnosis is established only after sarcomalike primary lung malignancies and metastatic disease have been excluded. Primary sarcomas of the thorax are classified according to their histologic features and constitute a large group of tumors that occur in the lung, mediastinum, pleura, and chest wall. Angiosarcoma, leiomyosarcoma, rhabdomyosarcoma, and mesothelioma (sarcomatoid variant) are the most common primary intrathoracic sarcomas. Ewing sarcoma, primitive neuroectodermal tumor, chondrosarcoma, malignant fibrous histiocytoma, osteosarcoma, synovial sarcoma, and fibrosarcoma usually arise in the chest wall. Although primary thoracic sarcomas commonly manifest as large, heterogeneous masses, they have a wide spectrum of radiologic manifestations, including solitary pulmonary nodules, central endobronchial tumors, and intraluminal masses within the pulmonary arteries. The different histologic types of sarcomas are frequently indistinguishable at radiologic analysis. However, differences in clinical presentation and the location of the tumor, as well as morphologic features such as calcification within the mass and rib involvement, can be useful in suggesting the appropriate diagnosis. For example, a large rib mass in a child with fever and malaise indicates a Ewing sarcoma, a mass with a calcified matrix is likely a chondrosarcoma or osteosarcoma, and a pulmonary artery mass is likely a leiomyosarcoma.

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“…Synovial sarcomas chiefly occur in the para‐articular deep soft tissues of the extremities of young adults. However, a minority of this type of tumor occur in unusual anatomical sites 2–31 …”

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confidence: 99%

Primary synovial sarcoma of the kidney: Report of a case confirmed by molecular detection of the SYT‐SSX2 fusion transcripts

Koyama

Morimitsu

Morokuma

et al. 2001

Pathology International

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We describe an unusual case of primary synovial sarcoma of the kidney. A 47-year-old woman had a tumor massively replacing the right kidney. There were no primary extrarenal neoplastic lesions. Microscopically, the tumor was composed of a cellular proliferation of relatively uniform spindle-shaped cells having atypical spindle or oval nuclei arranged in fascicles with tumor necrosis, without epithelial areas. Immunohistochemically, a small number of the tumor cells were positive for epithelial markers such as cytokeratin and epithelial membrane antigen. The SYT-SSX2 fusion transcripts were detected by a reverse transcription-polymerase chain reaction (RT-PCR) using RNA extracted from formalin-fixed, paraffin-embedded tissue. ETV6-NTRK3 fusion gene transcripts that result from t(12; 15)(p13;q25), which is characteristic of cellular congenital mesoblastic nephroma, were not demonstrated. To our knowledge, this is the ninth case of primary renal synovial sarcoma. This case report indicates that synovial sarcoma should be taken into account for the differential diagnosis of renal spindle cell tumors and the molecular assay detecting the SYT-SSX fusion transcripts is useful for the final diagnosis of synovial sarcoma arising in an unusual location.

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Synovial sarcoma with t(X:18) chromosomal translocation, cardiac involvement, and peripheral embolus

Cited by 6 publications

References 23 publications

Cardiogenic and obstructive shock: primary laryngeal synovial sarcoma with cardiac metastasis

Cardiogenic and obstructive shock: primary laryngeal synovial sarcoma with cardiac metastasis

Primary Thoracic Sarcomas

Primary synovial sarcoma of the kidney: Report of a case confirmed by molecular detection of the SYT‐SSX2 fusion transcripts

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