Synovial sepsis diagnostics and antimicrobial resistance: a one-health perspective

Abstract

This article, as part of the Currents in One Health series, reviews the current state of diagnostics for synovial sepsis. Synovial sepsis is a condition that affects veterinary and human medicine and requires coordinated efforts from both parties, as well as environmental considerations to accurately diagnose and preserve effective treatments. The article discusses best practices to identify the causative agent in septic synovitis, trends in bacterial identification and antimicrobial resistance patterns across common bacterial species, and a one-health perspective to optimize diagnostics across species. Antimicrobial resistance is a challenge facing both human and veterinary medicine and requires mindful and attentive prescribing to reduce the development of antimicrobial resistance and preserve antimicrobials for future application. The current standard of care for bacterial identification in veterinary practice is culture and antimicrobial susceptibility; however, positive culture rates from synovial sepsis cases often remain < 50%. Recent developments in advanced bacterial identification present opportunities for improved bacterial identification in synovial sepsis. Increased bacterial isolation will also help guide empirical antimicrobial therapy. Utilizing information and recommendations from both the human and veterinary literature will improve timely and accurate bacterial identification and therefore rapid and effective treatment of synovial sepsis across species and limit the development of antimicrobial resistance.

Faster perfusate instillation time results in more systemic leakage of amikacin sulfate when performing intravenous regional limb perfusion in horses

“…spp, Staphylococcus spp, and Enterobacteriaceae spp. [14][15][16][17] With a spectrum including gram-negative bacteria as well as Staphylococcus spp, amikacin continues to be a good choice that has been proven to be effective against these common isolates. 18 Additionally, performing IVRLP using aminoglycoside antibiotics is advantageous as a higher ratio of maximum drug concentration (C MAX ) to the minimum inhibitory concentration (MIC) results in an improved bactericidal effect.…”