Synovitis, Acne pustulosa, pustuläre Psoriasis, Hyperostosis und Osteitis (= SAPHO), Chronische, rekurrierende, multifokale Osteomyelitis (= CRMO) und Spondarthritiden - eine Zusammenfassung

Schilling, F.

doi:10.1055/s-2001-19059

Cited by 10 publications

(6 citation statements)

References 10 publications

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“…Following the treatment protocol of Schilling 8 we started treatment with oral azithromycin 500 mg daily for 3 days and then every third day, as well as calcitonin 100 IE every third day as a subcutaneous injection, both for a total of 4 weeks. The patient did not tolerate the injections and had nausea and diarrhea.…”

Section: Therapymentioning

confidence: 99%

Chronic recurrent multifocal osteomyelitis presenting as pseudoseptic sacroiliac joint arthritis: a case report and review of literature

El-Zayat¹,

Efe²,

Fuchs-Winkelmann³

et al. 2010

Current Orthopaedic Practice

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Section: Therapymentioning

confidence: 99%

Chronic recurrent multifocal osteomyelitis presenting as pseudoseptic sacroiliac joint arthritis: a case report and review of literature

El-Zayat¹,

Efe²,

Fuchs-Winkelmann³

et al. 2010

Current Orthopaedic Practice

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“…Die CRMO ist zwar neu definiert und einerseits als sterile "primär chronische Poly-Osteomyelitis" charakterisiert worden (49). Deren osteomyelitisches Substrat andererseits aber imponiert als eine immunpathologische reaktive Entzündung, die als Analogon zur reaktiven Arthritis verstanden werden kann.…”

Section: Diskussionunclassified

“…spezifischen Therapie, wobei sich eine kombinierte Langzeitmedikation aus Azithromycin und Calcitonin (45,49) nach unseren eigenen Erfahrungen bewährt hat und vom Darm bislang sehr gut vertragen wird. Die Makrolide haben sich vielfach als antiphlogistisch und immunmodulatorisch erwiesen, und speziell Azithromycin zeigt pharmakokinetisch eine hohe Gewebsanreicherung im lymphatischen System einschließlich Knochenmark.…”

Section: Diskussionunclassified

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Die chronische rekurrierende multifokale Osteomyelitis in Assoziation mit chronisch entz�ndlichen Darmerkrankungen: Die enteropathische CRMO

Schilling

Märker‐Hermann

2003

Zeitschrift f�r Rheumatologie

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The enterogenic reactive arthritides and entheropathic spondyloarthropathies are well-known entities. The so-called gut iteropathy concept offers an interesting working hypothesis to link the gut inflammation and the lymphocytic infiltration of the synovium. However, the association of rheumatic diseases belonging to the entity of the SAPHO syndrome with inflammatory bowel diseases (IBD) has only been rarely described in the literature. Among 138 cases of our (heterogenic) SAPHO cohort, we detected 5 patients (1 male, 4 females) with a proven association of SAPHO syndrome with IBD (in 4 cases Crohn's disease, in 1 case ulcerative colitis). Two patients belonged to the juvenileadolescent form and 3 to the adult form of SAPHO syndrome. In all cases the underlying osteoarticluar disease was classified as chronic recurrent multifocal osteomyelitis (CRMO), 2 of them presenting as inflammatory anterior chest wall syndrome. There was a strong association with psoriatic pustular dermatitis. Thus, we present 5 cases of "enteropathic CRMO" demonstrating several analogies to the enteropathic spondyloarthropathies. Both disease entities have in common i) metachronic development with osteoarticluar manifestations often preceding the gastrointestinal disease; ii) Crohn's like lesions that may develop from the stomach to the colon; iii) concomittent or intermittent skin pustulosis which mostly resolves; iiii) the gastrointestinal disease that often dominates the whole syndrome namely in the longterm follow-up. We suggest to transfer the hypothesis of the gut-synovium axis of enteropathic spondyloarthropathies to the entity of CRMO. This concept offers an opportunity to link the target organs gut mucosa, bone marrow and the skin via homing of antigen specific lymphocytes. This concept may help to better understand the pathogenesis of the "Skibo" (i. e., skin-bone) disease CRMO.

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“…Auch gibt es neben der "POPP" weitere sehr seltene Krankheitsbilder, die (im weitesten Sinn) differentialdiagnostisch zu erwägen sind: die pustulöse Akroosteitis (8), die psoriatische Akropachydermie (6), das SAPHO-Syndrom, die chronisch-multifokale rekurrierende Osteomyelitis (9,11,12) und die noch vor 5 bis 10 Jahren publizierte "floride reaktive Periostitis". Letztere wurde vom periostalen Osteosarkom abgegrenzt und mit Antibiotika behandelt.…”

unclassified

Psoriatrische Onycho-Pachydermo-Periostitis

Miehle

2002

Zeitschrift f�r Rheumatologie

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Synovitis, Acne pustulosa, pustuläre Psoriasis, Hyperostosis und Osteitis (= SAPHO), Chronische, rekurrierende, multifokale Osteomyelitis (= CRMO) und Spondarthritiden - eine Zusammenfassung

Cited by 10 publications

References 10 publications

Chronic recurrent multifocal osteomyelitis presenting as pseudoseptic sacroiliac joint arthritis: a case report and review of literature

Chronic recurrent multifocal osteomyelitis presenting as pseudoseptic sacroiliac joint arthritis: a case report and review of literature

Die chronische rekurrierende multifokale Osteomyelitis in Assoziation mit chronisch entz�ndlichen Darmerkrankungen: Die enteropathische CRMO

Psoriatrische Onycho-Pachydermo-Periostitis

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