Synovitis in Polymyalgia Rheumatica: An Immunogenetic Study

Salvarani, Carlo; Rossi, F; Macchioni, Pierluigi; Mantovani, W; Veneziani, M; Boiardi, Luigi; Lodi, L.; Portioli, I

doi:10.1093/rheumatology/31.10.720

Cited by 5 publications

(3 citation statements)

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“…Other studies have not found any association between peripheral synovitis and rheumatoid epitope 618 26 Uddhammar et al followed up 47 patients for three years 6. No difference in the percentages of DR4 positive and DR4 negative PMR patients still receiving corticosteroid treatment at the end of follow up was observed.…”

Section: Discussionmentioning

confidence: 92%

HLA-DRB1 alleles associated with polymyalgia rheumatica in northern Italy: correlation with disease severity

Salvarani

Boiardi

Mantovani

et al. 1999

Annals of the Rheumatic Diseases

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Section: Discussionmentioning

confidence: 92%

HLA-DRB1 alleles associated with polymyalgia rheumatica in northern Italy: correlation with disease severity

Salvarani

Boiardi

Mantovani

et al. 1999

Annals of the Rheumatic Diseases

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“…These symptoms differ from patients with rheumatoid arthritis (RA) but occur among patients with other diseases within the SpA group. Other manifestations in patients with PsA include uveitis [11,12] distal extremity swelling with pitting oedema [13], possibly because of lymphatic obstruction [14], and discoloration of the skin over affected joints [15]. As yet neither psoriasis nor PsA have been described as a disease with systemic manifestations.…”

Section: Introductionmentioning

confidence: 99%

Psoriatic Arthritis-New Insights Give New Options for Treatment

Alenius

2007

CMC

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Psoriatic arthritis (PsA), an inflammatory joint disease associated with psoriasis of the skin, has a heterogeneous pattern expressed by different manifestations, such as mild mono-oligoarthritis, a very severe, erosive and destructive polyarthritis indistinguishable from rheumatoid arthritis, and spondylarthropathy with axial involvement or enthesitis. The disease pattern often differs between patients as well as within the same patient over time. Measurable inflammatory activity is not always evident. Early detection of inflamed joints or axial involvement in patients with PsA is important in order to reduce the inflammation and prevent destruction, deformity and functional disability in the joints involved. Several factors, e.g., genetic, immunological, environmental and vascular, have been proposed to be of importance for the aetiology, the expression and prognosis of PsA. The basic treatment for PsA has been administration of non-steroid anti-inflammatory drugs (NSAIDs). Few disease modifying anti-rheumatic drugs (DMARDs) have been available due to a lack of efficacy of most of the DMARDs used for other rheumatic diseases. New insights into genetic, immunological and vascular factors in PsA are of interest as possible targets for future therapy and will be discussed in this review.

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“…Although the pathogenesis of GCA has been extensively studied, the pathogenic mechanisms underlying PMR are less clearly defined. The evidence that PMR occurs almost exclusively in individuals aged over 50 years may indicate that, similarly to GCA, age-related immune alterations in genetically predisposed subjects contribute to the development of the disease (9,10). In this review we will discuss recent findings regarding the pathogenesis of PMR (Figure 1).…”

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confidence: 99%

Pathogenesis of polymyalgia rheumatica

Guggino¹,

Ferrante²,

Macaluso³

et al. 2018

Reumatismo

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REVIEW SUMMARYPolymyalgia rheumatica (PMR) is a chronic, inflammatory disorder of unknown cause, almost exclusively occurring in people aged over 50 and often associated with giant cell arteritis. The evidence that PMR occurs almost exclusively in individuals aged over 50 may indicate that age-related immune alterations in genetically predisposed subjects contribute to development of the disease. Several infectious agents have been investigated as possible triggers of PMR even though the results are inconclusive. Activation of the innate and adaptive immune systems has been proved in PMR patients as demonstrated by the activation of dendritic cells and monocytes/macrophages and the altered balance between Th17 and Treg cells. Disturbed B cell distribution and function have been also demonstrated in PMR patients suggesting a pathogenesis more complex than previously imagined. In this review we will discuss the recent findings regarding the pathogenesis of PMR.

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Synovitis in Polymyalgia Rheumatica: An Immunogenetic Study

Cited by 5 publications

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HLA-DRB1 alleles associated with polymyalgia rheumatica in northern Italy: correlation with disease severity

HLA-DRB1 alleles associated with polymyalgia rheumatica in northern Italy: correlation with disease severity

Psoriatic Arthritis-New Insights Give New Options for Treatment

Pathogenesis of polymyalgia rheumatica

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