Synthèse de polyglycérols linéaires et cycliques. Tensioactifs polyglycérylés : synthèse et caractérisations

Debaig, Catherine; Benvegnu, Thierry; Plusquellec, Daniel

doi:10.1051/ocl.2002.0155

Cited by 7 publications

(3 citation statements)

References 21 publications

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“…In contrast to the aforementioned chain growth mechanisms, low molecular weight linear oligoglycerols have been prepared as perfectly monodisperse oligomers by various multistep syntheses. , …”

Section: Synthetic Strategies For Linpgmentioning

confidence: 99%

Beyond Poly(ethylene glycol): Linear Polyglycerol as a Multifunctional Polyether for Biomedical and Pharmaceutical Applications

2014

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Polyglycerols (sometimes also called "polyglycidols") represent a class of highly biocompatible and multihydroxy-functional polymers that may be considered as a multifunctional analogue of poly(ethylene glycol) (PEG). Various architectures based on a polyglycerol scaffold are feasible depending on the monomer employed. While polymerization of glycidol leads to hyperbranched polyglycerols, the precisely defined linear analogue is obtained by using suitably protected glycidol as a monomer, followed by removal of the protective group in a postpolymerization step. This review summarizes the properties and synthetic approaches toward linear polyglycerols (linPG), which are at present mainly based on the application of ethoxyethyl glycidyl ether (EEGE) as an acetal-protected glycidol derivative. Particular emphasis is placed on the manifold functionalization strategies including, e.g., the synthesis of end-functional linPGs or multiheterofunctional modifications at the polyether backbone. Potential applications like bioconjugation and utilization as a component in degradable biomaterials or for diagnostics, in which polyglycerol acts as a promising PEG substitute are discussed. In the last section, the important role of linear polyglycerol as a macroinitiator or as a highly hydrophilic segment in block co- or terpolymers is highlighted.

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Section: Synthetic Strategies For Linpgmentioning

confidence: 99%

Beyond Poly(ethylene glycol): Linear Polyglycerol as a Multifunctional Polyether for Biomedical and Pharmaceutical Applications

2014

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“…[64] However, to obtain satisfactory yields of the target oligoglycerol, various strategies involving protective agents, allylic ethers, glycidol, or epichlorhydrin were usually required. [65,66] As a result of environmental concerns, the direct and catalytic oligomerization of glycerol is much more attractive. However, as for any polymerization reaction, control of the glycerol polymerization with the aim of selectively producing one desired oligomer remains an important scientific challenge.…”

Section: Catalytic Cleavage Of Dibenzyl Ether Bondsmentioning

confidence: 99%

Rational Design of Solid Catalysts for the Selective Use of Glycerol as a Natural Organic Building Block

2008

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Glycerol is the main co-product of the vegetable oils industry (especially biodiesel). With the rapid development of oleochemistry, the production of glycerol is rapidly increasing and chemists are trying to find new applications of glycerol to encourage a better industrial development of vegetable oils. In this Review, attention is focused on the selective use of glycerol as a safe organic building block for organic chemistry. An overview is given of the different heterogeneous catalytic routes developed by chemists for the successful and environmentally friendly use of glycerol in sustainable organic chemistry. In particular, the effects of different catalyst structural parameters are discussed to clearly highlight how catalysis can help organic chemists to overcome the drawbacks stemming from the use of glycerol as a safe organic building block. It is shown that heterogeneous catalysis offers efficient routes for bypassing the traditional use of highly toxic and expensive epichlorohydrin, 3-chloro-1,2-propanediol, or glycidol, which are usually used as a glyceryl donor in organic chemistry.

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“…Although polyglycerol based surfactants are already well known 11,12 and common, especially in the food and cosmetic industries, 13,14 low molecular weight glycerol derivatives have been almost totally ignored during the last century. Only a few of them are used, e.g.…”

Section: Introductionmentioning

confidence: 99%

Short chain glycerol 1-monoethers—a new class of green solvo-surfactants

et al. 2006

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The synthesis of short eco-friendly amphiphilic compounds derived from glycerol was carried out. These compounds, called solvo-surfactants, are of great interest since they exhibit both properties of solvents, e.g. volatility, solubilization of organics, and surfactants, e.g. reduction of interfacial tensions, formation of emulsions and microemulsions. Their surface activity was studied, and binary phase diagrams with water were drawn. Their sensitivity to various electrolytes from Hofmeister's series was also investigated. Short chain glycerol 1-monoethers constitute a new class of green solvo-surfactants with excellent properties, that should be seriously considered for the replacement of reprotoxic glycol ethers. They have, moreover, the advantage of helping to solve the problem of an over-production of glycerol, which is a major side-product of the biocarburant industry.

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Synthèse de polyglycérols linéaires et cycliques. Tensioactifs polyglycérylés : synthèse et caractérisations

Cited by 7 publications

References 21 publications

Beyond Poly(ethylene glycol): Linear Polyglycerol as a Multifunctional Polyether for Biomedical and Pharmaceutical Applications

Beyond Poly(ethylene glycol): Linear Polyglycerol as a Multifunctional Polyether for Biomedical and Pharmaceutical Applications

Rational Design of Solid Catalysts for the Selective Use of Glycerol as a Natural Organic Building Block

Short chain glycerol 1-monoethers—a new class of green solvo-surfactants

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