Synthèse et propriétés biologiques des pyrazolo〚4,3-c〛triazolo〚4,3-a〛〚1,5〛benzodiazépines

(4Z)-4-(2-Oxopropylidene)-1,3-bis(prop-2-en-1-yl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one

“…1,5-Benzodiazepine derivatives have attracted much attention as they exhibit pronounced anxiolytic, sedative, hypnotic and anticonvulsant activities with low toxicity (Landquist et al, 1984;Hamor et al, 1984;Ben-Cherif et al, 2010). They are also used as an intermediates for the synthesis of new heterocyclic systems (Ahabchane et al, 2001;Minnih et al, 2014). In a continuation of our work on the synthesis and structure of 1,5benzodiazepine derivatives (Sebhaoui et al, 2016), we report here the preparation and crystal structure of the title compound.…”

1-Ethyl-4-phenyl-1H-1,5-benzodiazepin-2(3H)-one

“…Benzodiazepines are very important compounds widely used as psychotropic agents (Zellou et al, 1998a;Kanyonga et al, 2009) and hypnotic agents (Zellou et al, 1998b). Background to the class of 2,3-dihydro-1H-1,5-benzodiazepin-2-ones is given by Ahabchane et al (2001). Continuing our interest in the synthesis of new 1,5-benzodiazepin-2one derivatives, we report herein on the synthesis and crystal structure of the title compound, obtained under phase-transfer catalysis conditions.…”

A Convenient Method for the Synthesis of 1,5-benzodiazepin-2-one

“…These beneficial health properties have led to several investigations on their chemical structures and have initiated a number of synthetic efforts to access 1,5-benzodiazepine derivatives [15,[19][20][21][22][23][24][25][26][27][28]. In this work, we describe a new method for the synthesis of 3-hydroxy-1,5-benzodiazepin-2ones based on the condensation of o-phenylenediamines with a cis and trans ethyl 3-phenylglycidate.…”