Synthesen auf dem Phenothiazin‐Gebiet. 3. Mitteilung. Neue Phenothiazinderivate

Bourquin, Jean-Pierre; Schwarb, G.; Gamboni, G.; Fischer, R.; Ruesch, L.; Guldimann, S.; Theus, V.; Schenker, E.; Renz, J.

doi:10.1002/hlca.19590420124

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Cited by 8 publications

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Synthesen auf dem Phenothiazin‐Gebiet. 4. Mitteilung. N‐substituierte Mercapto‐azaphenothiazin‐Derivate

Bourquin¹,

Schwarb²,

Gamboni³

et al. 1959

Helvetica Chimica Acta

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Im Rahmen unserer Untersuchungen uber Mercaptophenothiazin-Derivate I 2), die durch geeigncte Substitution am Ringstickstoff 3, zu pharmakologisch wirksamen Substanzen gefiihrt habcn, wurden durch entsprechende Synthese auch analoge Mercapto-azaphenothiazine I1 dargestellt. SUMMARYThe synthesis of a series of pharmacologically interesting N-substituted derivates of 6-methylmercapto-azaphenothiazine is described.Pharmazeutisch-chemisches Laboratorium SANDOZ, Base1

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Synthesen auf dem Phenothiazin‐Gebiet. 4. Mitteilung. N‐substituierte Mercapto‐azaphenothiazin‐Derivate

Bourquin¹,

Schwarb²,

Gamboni³

et al. 1959

Helvetica Chimica Acta

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Synthesis of possible metabolites of chlorpromazine. I. 7‐hydroxy derivatives of chlorpromazine, nor₁‐chlorpromazine and nor₂‐chlorpromazine

Nodiff

Ina

Oda

et al. 1967

Journal of Heterocyclic Chem

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A new ring closure reaction of 2‐phenoxyphenols and 3‐(phenoxy)pyridines. Synthesis of halogenated 10‐methylphenoxazines and 10‐methyl[1,4]benzoxazino[3,2‐b]pyridines

Fuhrer

Sutter

Weis

1979

Journal of Heterocyclic Chem

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The cyclization of 2‐(2‐chloro(bromo)phenoxy)anilines and 3‐(phenoxy)pyridines to 10‐methylphenoxazines and 10‐methyl[1,4]benzoxazino[3,2‐b]pyridines, respectively, by means of dimethyl methylphosphonate is reported. The cyclization reaction proceeded with expulsion of methyl ether. Demethylation of some 10‐methylphenoxazines was achieved with pyridine hydrobromide. Nitration was carried out with sodium nitrite, and by reduction of the nitro groups the corresponding amines were prepared.

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Synthesen auf dem Phenothiazin‐Gebiet. 3. Mitteilung. Neue Phenothiazinderivate

Abstract: The synthesis and properties of various N‐ and C‐3‐substituted derivatives of phenothiazine are described.

Cited by 8 publications

References 20 publications

Synthesen auf dem Phenothiazin‐Gebiet. 4. Mitteilung. N‐substituierte Mercapto‐azaphenothiazin‐Derivate

Synthesen auf dem Phenothiazin‐Gebiet. 4. Mitteilung. N‐substituierte Mercapto‐azaphenothiazin‐Derivate

Synthesis of possible metabolites of chlorpromazine. I. 7‐hydroxy derivatives of chlorpromazine, nor₁‐chlorpromazine and nor₂‐chlorpromazine

A new ring closure reaction of 2‐phenoxyphenols and 3‐(phenoxy)pyridines. Synthesis of halogenated 10‐methylphenoxazines and 10‐methyl[1,4]benzoxazino[3,2‐b]pyridines

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Synthesen auf dem Phenothiazin‐Gebiet. 3. Mitteilung. Neue Phenothiazinderivate

Abstract: The synthesis and properties of various N‐ and C‐3‐substituted derivatives of phenothiazine are described.

Cited by 8 publications

References 20 publications

Synthesen auf dem Phenothiazin‐Gebiet. 4. Mitteilung. N‐substituierte Mercapto‐azaphenothiazin‐Derivate

Synthesen auf dem Phenothiazin‐Gebiet. 4. Mitteilung. N‐substituierte Mercapto‐azaphenothiazin‐Derivate

Synthesis of possible metabolites of chlorpromazine. I. 7‐hydroxy derivatives of chlorpromazine, nor1‐chlorpromazine and nor2‐chlorpromazine

A new ring closure reaction of 2‐phenoxyphenols and 3‐(phenoxy)pyridines. Synthesis of halogenated 10‐methylphenoxazines and 10‐methyl[1,4]benzoxazino[3,2‐b]pyridines

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Synthesis of possible metabolites of chlorpromazine. I. 7‐hydroxy derivatives of chlorpromazine, nor₁‐chlorpromazine and nor₂‐chlorpromazine