Synthesen in der »Oxazinreihe«

Abstract

Ale s Oxazine Q bezeichnet man eine Reihe von Farbstoffen I), welche sich von dem Chromogen ableiten, das A. B e r n t h s e n a) unlangst durch Erhitzen von o -Amidophenol mit Brenzcatechin dargestellt und als 2 Phenazoxin Q bezeichnet hat.0. W i d m a n 3) fasst in seiner Abhaodlung Bzur N o m e n c l a t u r d e r V e r b i n d u n g e n , w e l c h e S t i c k s t o f f k e r n e e n t h a l t e n a d e n Begriff der B O x a z i n e c oder ~A z o x i n e~)~ noch weiter, indem er die Definition giebt: s A z o x i n b e d e u t e t e i n e s o l c h e V e r b i n d u n g , w e l c h e e i n e n s e c h s g l i e d r i g e n , aus e i n e m S t i c k s t o f f -, e i n e m S a u e r s t o f f -u n d v i e r K o h l e n s t o f f a t o m e n b e s t e h e n d e u , v o n 8 B i n d u n g e n z u s a m m e n g e h a l t e n e n K e r n e n t h a l t a . Er unterscheidet drei Klassen von Azoxioen, welche sich von den drei Kernen

Kinetic Data on the Inhibition of High‐affinity Choline Transport into Rat Forebrain Synaptosomes by Choline‐like Compounds and Nitrogen Mustard Analogues

“…Recrystallization of the quaternary salt was from ethanol. A sharp melting point was found at 160°C, which is in agreement with the results ofKnorr (1904).O t h e r m a t e r i a l s w e r e o b t a i n e d a s f o l l o w s : hemicholinium-3 from Aldrich Chemical Co. Inc.; Milwaukee, Wisconsin; [N-Me-"Hlcholine chloride (10. l Ci/mmol) and Phase Combining System (PCS) from A m e r s h a m C o r p . , O a k v i l l e , O n t a r i o , C a n a d a : trichloroacetic acid from BDH Chemical Co., Toronto, Canada; precoated TLC sheets, cellulose #553 1 (without fluorescence indicator), 0.10-mm layer thickness, aluminum support from EM Laboratories Inc., BDH Chemical Co., Toronto, Canada; Tris-HCI and Tham from Fisher Scientific Co., Toronto, Canada: sodium thiosulphate, Mallinckrodt, St. Louis, Missouri; and choline iodide and albumin crystallized from bovine serum from Sigma Chemical Co., St. Louis, Missouri.…”

Synthesis of 2-(alkylamino)-1-phenylethane-1-thiosulfuric acids, potential schistosomicides

“…The literature describes various synthetic methods for the preparation of β-aminoalcohols, including the substitution reaction of primary and secondary amines with alkylene chlorohydrins [19][20] ; the reduction of α-hydroxyamides 21 and the opening of 1,2-epoxyalkanes by primary and secondary amines 22 . This last method was chosen because of its simplicity and the availability of starting materials.…”

Alkanolamides Sterically Related to Ergometrine

“…Synthesis of alkanolamides by reaction of acid chlorides and aminoalcohols does not appear to have been widely investigated, and published work (Knorr and Rossler, 1903;Brinziger and Koddebusch, 1949) has been largely concerned with reactions of aromatic acid chlorides. We have found that the acid chloride of 3-dimethylaminopropionic acid in chloroform reacts with ethanolamine to produce almost exclusively the unwanted O,N-bis-(3'-dimethylaminopropionyl)-2-aminoethanol (XXV), with a small yield of 2-aminoethyl 3-dimethylaminopropionate (XXVI).…”