Synthesen und spektroskopische Untersuchungen substituierter cis‐ und trans‐Dichlorobis(triphenylphosphan)platin(II)‐Verbindungen

Abstract

Verbindungen des Typs cis-und trans-Dichlorobis(triphenylphosphan)platin(II) (3), deren an denPhosphor gebundene Phenyl-Ringe in yerschiedenen Positionen mit Substituenten unterschiedlichen elektronischen Charakters substituiert sind, werden dargestellt. Mit den Kopplungskonstanten 1J[1"Pt,31P] und den Platin-Chlor-Valenzschwingungsfrequenzen werden Kriterien fur die sichere Unterscheidung zwischen ckund truns-Konfiguration am Platin aufgezeigt; es besteht ein h e a r e r Zusammenhang zwischen der Summe der Substituenten-Konstanten der in das Triphenylphosphan eingefuhrten Substituenten und den Kopplungskonstanten 1J['gSPt,3'P]. Syntheses and Spectroscopic Investigations of Substituted cisand trans-Dichlorobis-(triphenylphosphane)platinum(II) CompoundsCompounds of the type cis-and truns-dichlorobis(triphenylphosphane)platinum(II) (3) with substituents of different electronic character in the phenyl rings bonded to phosphorus have been synthesized. The coupling constants 'J['9SPt,3'P] and the chloro-platinum valence vibrational frequencies are demonstrated to be criteria for unambiguous discrimination between cis-and trans-configurations at platinum; a linear correlation exists between the sum of the a-constants of the substituents at the triphenylphosphane and the coupling constants 'J['95Pt,31P].

In Vitro Anticancer Activity of Nanoformulated Mono‐ and Di‐nuclear Pt Compounds

“…It should be noted that when the single crystals of 4 were immersed in CD 2 Cl 2 overnight, its 31 P NMR indicated that the singlet at 18.6 ppm shifted to 12.0 ppm, suggesting a trans ‐to‐ cis structural change (Figure S5a, and S5b). Similar observation was also made by Brune et al [16] . who demonstrated that 4 undergoes a trans ‐to‐ cis structural change in CH 2 Cl 2 at r.t.…”

“…singlet at 18.6 ppm shifted to 12.0 ppm, suggesting a trans-tocis structural change (Figure S5a, and S5b). Similar observation was also made by Brune et al [16] who demonstrated that 4 undergoes a trans-to-cis structural change in CH 2 Cl 2 at r.t. The purities of all five complexes were confirmed by microanalyses and Fourier-transform infrared (FT-IR) spectra.…”

“…[3,5e,11c,13] In this work, we have studied the nanoparticle formation of a class of mononuclear and dinuclear Pt-based complexes featuring P-and/or S-based ligands using amphiphilic polymer Pluronic® F-127. [14] These complexes included mononuclear cis-PtCl 2 (PPh 3 ) 2 (1), [15] [Pt-(PPh 3 ) 2 (LÀ Cys)] • H 2 O (3, LÀ Cys = L-cysteinate), trans-PtCl 2 (PPh 2 PhNMe 2 ) 2 (4, PPh 2 PhNMe 2 = 4-(dimethylamine) triphenylphosphine) [16] and trans-PtI 2 (PPh 2 PhNMe 2 ) 2 (5), as well as a dinuclear Pt cluster Pt 2 (μ-S) 2 (PPh 3 ) 4 (2). [17] We hypothesized that the use of a strong-field P-based ligand would facilitate the dissociation of PtÀ Cl (1), PtÀ S (2, 3), or PtÀ N (3) bonds at the trans position to facilitate DNA cross-linking, similar to the action mechanism of cisplatin.…”

The development of a ‘safety‐catch’ arylgermane for biaryl synthesis by palladium‐catalysed germyl‐stille cross‐coupling

“…The reaction mixture was then heated at reflux for 24 h, before being partitioned between Et 2 O (3 × 10 ml) and distilled water (10 ml). Organic washings were combined, dried with MgSO 4 , filtered and concentrated in vacuo, before being purified on a silica SPE cartridge (5 g, cyclohexane) to give 4-methyl-3 , 5 -bis(trifluoromethyl)biphenyl 11a 97 …”

Cover Picture: On the Importance of Anion–π Interactions in the Mechanism of Sulfide:Quinone Oxidoreductase (Chem. Asian J. 11/2013)

“…(4‐CF 3 C 6 H 4 ) 3 P,23 (3‐CF 3 C 6 H 4 ) 3 P,24 (4‐ClC 6 H 4 ) 3 P,25 and (3,4,5‐F 3 C 6 H 2 ) 3 P26 were synthesized according to the literature. Other materials were obtained from commercial suppliers.…”