Syntheses and antimicrobial activities of ogipeptin derivatives

Total Synthesis and Structural Elucidation of Ogipeptins

“…Recently, we studied the structure–activity relationships of ogipeptin derivatives using combinatorial semisynthetic approaches . In that study, we obtained novel acyl side-chain replacement ogipeptin derivatives that have antibacterial activity against Gram-negative bacteria and significantly reduced nephrotoxicity compared to that of colistin.…”

“…7−9 Recently, we studied the structure−activity relationships of ogipeptin derivatives using combinatorial semisynthetic approaches. 10 In that study, we obtained novel acyl sidechain replacement ogipeptin derivatives that have antibacterial activity against Gram-negative bacteria and significantly reduced nephrotoxicity compared to that of colistin. On the basis of those results, we thought that there was not enough acyl side-chain replacement to enhance the antimicrobial activity of ogipeptin derivatives.…”