Syntheses and Antiulcer Activities of Novel 2-((6,7,8,9-Tetrahydro-5H-cyclohepta(b)pyridin-9-yl)sulfin-yl)-1H-benzimidazole Analogues.

Yamada, Shin‐ichi; Goto, T.; Shimanuki, Eiji; Narita, Sen-ichi

doi:10.1248/cpb.42.718

Cited by 4 publications

(2 citation statements)

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“…Anti-Alzheimer's agents [192]- [194], Angiotensin II -AT1 Receptor Antagonist [195]- [200], Antiulcer activity [201]- [204], Anti-Tubercular activity [205]- [211],…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…In addition to the above medical applications, benzimidazole derivatives have been widely used as an essential part of biological applications including: antihypertensive activity, 154 155 156 157 158 antiprotozoal activity, 159–163 antiviral activity, 164–167 anthelmintic activity, 168 169 170 171 172 antidiabetic agents, 173 174 175 176 177 analgesic activity, 78 , 178 179 180 181 antispasmodic activity, 182 183 antidepressant activity, 184 185 186 187 188 189 sphingosine kinase 1 inhibitor, 190 191 anti-Alzheimer’s agents, 192 193 194 angiotensin II-AT1 receptor antagonists, 195 196 197 198 199 200 antiulcer activity, 201 202 203 204 anti-tubercular activity, 205 206 207 208 209 210 211 anti-HIV agents, 212 213 214 215 216 217 218 and anti-secretory activity. 219 220 221…”

Section: Biological Activity Of Benzimidazole Derivativesmentioning

confidence: 99%

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A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications

Alheety,

Mohammed,

Farhan

et al. 2023

SynOpen

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Benzimidazole is a heterocyclic compound formed by fusing the benzene ring with an imidazole ring that contains two nitrogen atoms. Benzimidazole and its derivatives are prepared in different ways, including condensation of o-phenylenediamine with carbonyl compounds (aldehydes and ketones) or with carboxylic acids and their derivatives. The benzimidazoles can also be prepared by rearranging other heterocyclic compounds such as quinoxaline derivatives, triazole derivatives, etc. In recent decades, benzimidazoles were prepared using green methods such as microwaves, ultrasound, and the use of an environmentally friendly catalyst, as well as photochemical reactions. Benzimidazoles have attracted the interest of scientists and researchers due to the great medical efficacy shown by them for various diseases. The benzimidazole derivatives show many pharmacological activities such as anticancer, anti-inflammatory, antioxidant, anticoagulant, antiviral, etc. This review focuses on shedding light on benzimidazole and its derivatives, the most important methods used to prepare it, as well as the biological applications in our daily lives.

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“…Anti-Alzheimer's agents [192]- [194], Angiotensin II -AT1 Receptor Antagonist [195]- [200], Antiulcer activity [201]- [204], Anti-Tubercular activity [205]- [211],…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Biological Activity Of Benzimidazole Derivativesmentioning

confidence: 99%

A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications

Alheety,

Mohammed,

Farhan

et al. 2023

SynOpen

View full text Add to dashboard Cite

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ChemInform Abstract: Synthesis and Antiulcer Activities of Novel 2‐((6,7,8,9‐Tetrahydro‐5H‐ cyclohepta(b)pyridin‐9‐yl)sulfinyl)‐1H‐benzimidazole Analogues.

et al. 1994

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Synthesis of Novel Thiophene, Thiazole and Coumarin Derivatives Based on Benzimidazole Nucleus and Their Cytotoxicity and Toxicity Evaluations

Mohareb

Abdallah

Mohamed³

2018

Chem. Pharm. Bull.

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The reactivity of compounds 2-(1-(2-chloroacetyl)-1H-benzo[d]imidazol-2-yl)acetonitrile 2 and 3-(1-(2-chloroacetyl)-1H-benzo[d]imidazol-2-yl)-2H-chromen-2-one 8 towards different chemical reagents were studied and a series of novel benzimidazole derivatives were obtained (2-6a-d and 8-12a-d). Moreover, in vitro growth inhibitory effect of the newly synthesized compounds were evaluated in term of [IC µM] against the six cancer cell lines, human lung carcinoma (A549), lung cancer (H460), human colorectal (HT29), gasteric cancer cell (MKN-45), glioma cell line (U87MG) and cellosaurus cell line (SMMC-7721) where foretinib was used as standard reference. The results showed that compounds 2 (only for A549 cell line), 3a, 4, 6c, 6d, 8, 9a, 9e and 9f were the most active compounds towards the six cancer cell lines. On the other hand, the toxicity of these most potent compounds against shrimp larvae indicated that compounds 3a, 4, 6d, 9e and 9f were non toxic while compounds 6c and 8 were very toxic and compounds 2 and 9a were harmful against the tested organisms.

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Syntheses and Antiulcer Activities of Novel 2-((6,7,8,9-Tetrahydro-5H-cyclohepta(b)pyridin-9-yl)sulfin-yl)-1H-benzimidazole Analogues.

Cited by 4 publications

References 0 publications

A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications

A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications

ChemInform Abstract: Synthesis and Antiulcer Activities of Novel 2‐((6,7,8,9‐Tetrahydro‐5H‐ cyclohepta(b)pyridin‐9‐yl)sulfinyl)‐1H‐benzimidazole Analogues.

Synthesis of Novel Thiophene, Thiazole and Coumarin Derivatives Based on Benzimidazole Nucleus and Their Cytotoxicity and Toxicity Evaluations

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