Syntheses and Applications of Functionalized Bicyclo[3.2.1]octanes: Thirteen Years of Progress

Abstract

International audienc

Organocatalyzed Synthesis of [3.2.1] Bicyclooctanes

“…There are several reviews on this subject, as the excellent reviews of Rodriguez et al [10,11]. Taking in to account these reviews, the reactions appeared in the literature for the synthesis of the bicyclo[3.2.1] systems using organocatalysis from January 2013 to February 2018 and they are considered in this work.…”

Functionalization of the benzobicyclo[3.2.1] octadiene skeleton possessing one isolated double bond via photocatalytic oxygenation

“…Generally, the continual research of interest in the chemistry of this framework (functionalized bicyclo[3.2.1] skeleton) is mainly due to its ubiquity in numerous families of biologically active natural products coupled with its versatile reactivity, making it a very useful building block with a valuable impact in modern organic synthesis. 22 Moreover, our specific synthetic approach, photochemical cycloaddition followed by photooxygenation, for the preparation of this framework is connected directly with the important applications to the total synthesis of some natural products.…”

Formation of Polycyclic Skeletons by Photochemical Transformations of Pyridyl‐ and Thienylbutadiene Derivatives

“…[1] The bicyclo[3.2.1]octane skeleton is the basic framework of numerous important biologically active natural compounds and their diverse metabolites. [3,4] The benzobicyclo[3.2.1]octadiene skeleton can thus be even more useful, as it can easily be transformed by adding various functional groups to the isolated double bond. This makes these derivatives powerful building blocks in organic synthetic strategies.…”