Syntheses and biomedical applications of hollow micro-/nano-spheres with large-through-holes

Abstract

Hollow micro-/nano-spheres with large-through-holes in shells (denoted as HMLS) have demonstrated great potential in biomedical applications owing to the combination of hollow structure and their porous shells. In this review, we provide a comprehensive overview of synthesis methods of HMLS obtained from the template-directed approach, shell-breaking method, Ostwald ripening and galvanic replacement primarily based on the formation mechanism of the large-through-holes in the shell. We further discuss the biomedical applications of HMLS including guest adsorption and encapsulation of proteins, drug/gene delivery, biomedical imaging, and theranostics. We conclude this review with some perspectives on the future research and development of the HMLS with desired morphologies and properties.

Micelle-template synthesis of hollow silica spheres for improving water vapor permeability of waterborne polyurethane membrane

“…Most studies on the filler materials of PU membrane have only focused on solid materials of macro-range and overlooked hollow micro-nano materials with mesoporous structure13, which resulted in an insufficient performance improvement. The usage of inorganic nanoparticles would be desirable filler materials to overcome the aforementioned limitations.…”

The Horizon of the Emulsion Particulate Strategy: Engineering Hollow Particles for Biomedical Applications

“…Currently, hollow particles with multilevel intrinsic architectures have been fabricated via solvent evaporation and suspension polymerization of the middle phase. Phase separation occurred with continual decomposition along the spinodal line to constitute a double emulsion (Figure 4c, [3][4]. Phase separation was triggered by solvent depletion.…”

“…[1] Owing to the hierarchical architecture and substantial surface area, multilevel encapsulations of biomolecules can be achieved with controlled behavior and high loading efficiency. [3] www.advmat.de www.advancedsciencenews.com engineered extracellular matrices for stem-cell-based tissue regenerations. [3] www.advmat.de www.advancedsciencenews.com engineered extracellular matrices for stem-cell-based tissue regenerations.…”

Porous nano-structured micro-granules from silica-milk bi-colloidal suspension: Synthesis and characterization

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