Syntheses and crystal structures of diorganotin(IV) bis(2‐pyridinethiolato‐N‐oxide) complexes

Abstract

(3) are synthesized and characterized by elemental analyses, IR, 1 H, 13 C, 119 Sn NMR spectroscopy, and their structures are determined by X-ray crystallography. In complex 1 the coordination geometry at tin is a skewtrapezoidal bipyramid, with cis-S,S and cis-O,O atoms occupying the trapezoidal plane and two n-butyl groups occupying the apical positions, which also exhibits strong π -π stacking interactions. In complexes 2 and 3 the geometry at tin is distorted cis-octahedral, with cis-O,O and cis-C,C atoms occupying the equatorial plane and trans-S,S atoms occupying the apical positions. Their in vitro cytotoxicity against two human tumour cell lines, MCF-7 and WiDr is reported. The ID 50 values found are comparable to those found for cis-platin, but lower than for many other diorganotin compounds.

Investigation on coordination modes of organotin(IV) complexes with 6-thiopurine and related ligands

“…Thus we can conclude that two S,N-chelating ligand asymmetrically coordinate to the center tin atom, different from that of complex 1, which adopts modes C and D simultaneously. And the conclusion is complementary to BarbieriÕs prediction according to the data of infrared and Mö ssbauer spectroscopy [9]. In addition, intermolecular hydrogen bonding (N(7)-H(7)Á Á ÁN(4) 2.766(7) Å , N(7)-H(7)-N(4) 164.87°for A and N(15)-H(15)Á Á ÁN (12) 2.867 (7) Å , N(15)-H(15)-N(12) 164.35°for B) is recognized, which associates the discrete molecule into a dimer.…”

“…In our previous work, we have studied the coordination behavior of five-and six-membered thiol/thione heterocycles to organotin(IV) [8,9]. As an extension of this research program and in connection with our current interest in the coordination chemistry of organotin(IV) compounds with heterocyclic thionates, we choose three fascinating ligands: Htpu, H 2 thpu and H 2 dtpu.…”

Antiproliferative and anti-tumor activity of organotin compounds

“…The screening results indicate that the activities of complexes 159, 160 and 161 are greater than cisplatin and comparable to diorganotin(IV) pyridine-2,6-dicarboxylates, but they are all less than those of the fluorinated aromatic carboxylates and polyoxaalkyltin compounds [52]. Complex 159, the most active among the three complexes, is comparable to or slightly better than doxorubicin against MCF-7 and tin fluorine-substituted aromatic carboxylates against WiDr [52]. Malignant gliomas are the most common primary brain tumors in humans [53].…”

“…The complexes di-n-butyldi(2-pyridinethiolato-N-oxide) tin(IV) (159), diphenyldi(2-pyridinethiolato-N-oxide)tin(IV) (160) and dibenzyldi(2-pyridinethiolato-N-oxide)tin(IV) (161) were evaluated for their in vitro cytotoxicity [52] (Table 5). The screening results indicate that the activities of complexes 159, 160 and 161 are greater than cisplatin and comparable to diorganotin(IV) pyridine-2,6-dicarboxylates, but they are all less than those of the fluorinated aromatic carboxylates and polyoxaalkyltin compounds [52].…”

Synthesis, Infrared and Mössbauer Studies of New Mono- Di- and Trinuclear Oxalato Triphenyltin (Iv) Derivatives

“…This paper reports the synthesis of new compounds containing the complex-anions [(C 2 0 4 ) 2 (SnPh 3 ) 3 All the precipitates were stirred no less than two hours , filtered and washed with hot ethanol.…”