Syntheses and Evaluation of New High-Capacity Gastric Antacids I

Schmank, Horst W.; Holbert, Jame S.M.; Beekman, Stewart M.

doi:10.1002/jps.2600540913

Journal of Pharmaceutical Sciences

1965

DOI: 10.1002/jps.2600540913

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Syntheses and Evaluation of New High-Capacity Gastric Antacids I

Horst W. Schmank¹,

Jame S.M. Holbert²,

Stewart M. Beekman³

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1966

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Cited by 5 publications

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Precipitation of Alkaline‐earth Metal Hydroxoberyllate, Hydroxoaluminates and Allied Salts from Aqueous Solution: Ionic Equilibria, Crystalline Phases and Precipitation Mechanisms

Packter¹

1981

Cryst Res and Technol

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The precipitations of alkaline-earth metal hydroxoberyllates and zincates, hydroxochromates (111), ferrates (111), aluminates and gallates, hydroxotitanates, zirconates and stannates (IV) and hydroxoantimonates (V) from different aqueous solutions are surveyed. The relevant ionic equilibria (hydroxoanion formation, precipitation of hydroxosalts, amphoteric metal hydroxides and alkaline-earth metal hydroxides) that may influence these precipitations are examined. The crystalline phases precipitated from different systems are tabulated and precipitation mechanisms are analysed.Die Fiillungen der Alkalinerdmetallhydroxoberyllete und zinkate, hydroxochromate(111) ferrate(III), aluminate und gallate, hydroxotitanate, zirkonate und stannate(1V) und hydroxoantimonate(V) werden in einer ubersicht dargestellt. Die wichtigen Typen der Ionengleichgewichte (hydroxoanion Bildung, Fiillung der Hydroxosalze und Hydroxide), die diese Fiillungen beeinflussen kiinnten, werden betrachtet. Die kristallinen Phasen, die in den verschiedenen Systemen ausfallen, werden tabellarisch wiedergegeben und die Fiillungsmechanismen analysiert.

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Precipitation of Alkaline‐earth Metal Hydroxoberyllate, Hydroxoaluminates and Allied Salts from Aqueous Solution: Ionic Equilibria, Crystalline Phases and Precipitation Mechanisms

Packter¹

1981

Cryst Res and Technol

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The precipitation of magnesium hydroxoaluminate hydrate powders from sodium hydroxoaluminate solutions: Precipitate phases and precipitation mechanisms

Packter¹,

Slaughter²

1984

Cryst. Res. Technol.

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Magnesium hytlroxoalnminate hydrates were prwipitated from different sodium hyrlroxoaluminate and hydroxoaluminate-hydroxide solutions at arnhient temperature, at C A~ = 0.1 M, OH/AI ratios = 4 -9 arid XS OH/AI ratios = 1-6. T h e precipitations were monitored hy potentio~netric (pH) measiiremerits while t h e final precipitate compositions were examined by chetnical analysis, infra-red spectrophotometry and thermal analysis.

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The coprecipitation of magnesium hydroxide aluminium hydroxide powders from aqueous solution with sodium hydroxide: Precipitate compositions and coprecipitation mechanisms

Packter

Panesar

1985

Cryst. Res. Technol.

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Magncsirim alumiiiiiim hydroxides woro coprecipitatcd from different mixed rrietal cation solutions -a t total CAI = 0.1 M and Mg/AI, ratios from 1 to 6 -with sodium hydroxide solut,iori at ambicnt temperature, with diffcrent prc-ageing conditions for tho aluminiiim hydroxidc prc-precipitate. The coprccipitatioris were monitored by poteritiometric ( p H ) titratiori and the final precipitate compositions were examined by chemical analysis, infrarcd spcctrophotometry and thermal analysis.Magnesium hydroxide was coprecipitated onto completely recrystallised aluminium hydroxidc as a simple mixture.Gencrally, with no to t,hree days pre-ageing, microcrystalline aluminium hydroxide was first precipitatcd at pH about 4; this then partially redissolved o n further addition of sodium hydroxide (to form hydroxoaluminate anion) and inagneaium alumiriium hydroxidc coprccipitates were formcd continuously a t pHs from 8. liitroductiuiiMagnesiuiii hydroxide -alu uiiniuiii hydroxide coprecipitate powders have iiiany useful industrial applications. High surface-area adsorbents and seini-conductor catalysts for many organic syntheses are prepared by the controlled thernial decoiiipositiori of these powders (ASILMORI': ; CIAEKE ; NURIO). 'l'he refractory niagnesiuni aluitiinatc (Spinel) can he prepared by the dehydration of suitable coprecipitates and then solid-state reaction of the aiiiorphous magnesia-alumina 'proto-spinel' product (BRAT-TON ; IVANUVA) ; KAMESWARI; MORTLANU). These powders also have important iiiedical applications in gastric anti-acid formulations (Anon. Chattanooga ; Anon. Heruies ; Anon. Keystone ; Anon. Kyowa ; SCHWANK). Previous experimental studies on the coprecipitations from mixed cation solutions with sodium hydroxide and the conipositions and structures of the coprecipitates have been reported by inorganic chemists (CHALYI; FEITKNECHT) and by soil chemists and geologists (BRINDLEY ; OASTIJCHE ; MASCOLO) ; these latter workers have proposed a brucite-aluminium hydroxide solid solution composition with a 'hydrotalcite' structure.

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Syntheses and Evaluation of New High-Capacity Gastric Antacids I

Cited by 5 publications

References 10 publications

Precipitation of Alkaline‐earth Metal Hydroxoberyllate, Hydroxoaluminates and Allied Salts from Aqueous Solution: Ionic Equilibria, Crystalline Phases and Precipitation Mechanisms

Precipitation of Alkaline‐earth Metal Hydroxoberyllate, Hydroxoaluminates and Allied Salts from Aqueous Solution: Ionic Equilibria, Crystalline Phases and Precipitation Mechanisms

The precipitation of magnesium hydroxoaluminate hydrate powders from sodium hydroxoaluminate solutions: Precipitate phases and precipitation mechanisms

The coprecipitation of magnesium hydroxide aluminium hydroxide powders from aqueous solution with sodium hydroxide: Precipitate compositions and coprecipitation mechanisms

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