Syntheses and photodynamic activity of some glucose-conjugated BODIPY dyes

Shivran, Neelam; Tyagi, Mrityunjay; Mula, Soumyaditya; Gupta, Pooja; Saha, Bhaskar; Patro, Birija Sankar; Chattopadhyay, Subrata

doi:10.1016/j.ejmech.2016.06.050

Cited by 78 publications

(36 citation statements)

References 66 publications

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“…Exogenous and endogenous apoptosis induced by PDT generally does not happen separately. In many studies, PDT mediated by phenalenone[ 181 ], coralyne[ 185 ], ALA[ 186 ], hypericin[ 187 ], dipyrromethene boron difluoride(BODIPY)[ 188 ], and zinc phthalocyanine[ 189 ] can cause both endogenous and exogenous apoptosis. This dual apoptosis phenomenon is generated primarily by signaling molecules, including p38 MAPK, Janus kinase (JAK)-2, and signal transducer and activator of transcription(STAT)-1.…”

Section: Impact Of Ros From Pdt On Cscsmentioning

confidence: 99%

Photodynamic therapy regulates fate of cancer stem cells through reactive oxygen species

Zhang

Wang

et al. 2020

WJSC

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Photodynamic therapy (PDT) is an effective and promising cancer treatment. PDT directly generates reactive oxygen species (ROS) through photochemical reactions. This oxygen-dependent exogenous ROS has anti-cancer stem cell (CSC) effect. In addition, PDT may also increase ROS production by altering metabolism, endoplasmic reticulum stress, or potential of mitochondrial membrane. It is known that the half-life of ROS in PDT is short, with high reactivity and limited diffusion distance. Therefore, the main targeting position of PDT is often the subcellular localization of photosensitizers, which is helpful for us to explain how PDT affects CSC characteristics, including differentiation, self-renewal, apoptosis, autophagy, and immunogenicity. Broadly speaking, excess ROS will damage the redox system and cause oxidative damage to molecules such as DNA, change mitochondrial permeability, activate unfolded protein response, autophagy, and CSC resting state. Therefore, understanding the molecular mechanism by which ROS affect CSCs is beneficial to improve the efficiency of PDT and prevent tumor recurrence and metastasis. In this article, we review the effects of two types of photochemical reactions on PDT, the metabolic processes, and the biological effects of ROS in different subcellular locations on CSCs.

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Section: Impact Of Ros From Pdt On Cscsmentioning

confidence: 99%

Photodynamic therapy regulates fate of cancer stem cells through reactive oxygen species

Zhang

Wang

et al. 2020

WJSC

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“…For these reasons, recently, a number of small-molecule carbohydrate-based fluorophores have been involved in the investigation of biological processes. [29] Among them, sugar-conjugated BODI-PYs have been studied as fluorescent labels for carbohydrates, [30] candidates for photodynamic therapy (PDT), [31] substrates in the preparation of near-IR fluorescent probes for profiling glycosidase activities [32] or for bioimaging. [33] This last aspect polarized our recent research and in this paragraph we describe our effort in the synthesis of biocompatible NIR carbohydrate-BODIPY imaging probes.…”

Section: Carbohydrates and Bodipys: Access To Biocompatible Nir Probesmentioning

confidence: 99%

BODIPY on Board of Sugars: A Short Enlightened Journey up to the Cells

et al. 2020

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BODIPY dyes have unique properties including: good stability in many solvents, high extinction coefficients, stability to light, sharp fluorescence emissions in the visible region with high fluorescence quantum yields. Moreover, through small chemical modifications of the skeleton, their luminescence properties can be finely tuned. As a consequence, during the last decades, this family of chromophores found extensive application in a wide range of fields. Carbohydrates play a relevant role in living organisms: their tasks range from energy storage to structural constituents of cells and tissues, they are involved in a variety of molecular recognition phenomena of physiological and biological relevance. The cyclic structure of natural D‐monosaccharides, also offers the conditions to use carbohydrates as building‐blocks in the construction of more complex, supramolecular structures. With these assumptions, in the last years our research in this field has focused on the study of synthesis, the photophysical features, and the application in the biomedical field of molecules that bear the synergic presence of these two tools. Pointing on the rationalization of this research, this article will provide a synthetic review of our last‐year's results in the field of BODIPY/glycosyl species, that can be classified in two principal sections: a) the rational synthesis and the photophysical studies of BODIPY dyads and antennas containing different kind of sugar units as scaffolds, ranging from mono‐ to disaccharide patterns, and b) the synthetic functionalization and modification of suitable BODIPY structures, for their punctual application in the field of bio‐imaging.

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“… 1 Traditional cancer therapeutic approaches, including surgery, chemotherapy and radiotherapy, sometimes suffer from invasion, high systemic damage, and no targeting and may inevitably destroy the immune system and result in an increased incidence of side effects. 2 – 5 Therefore, it is essential to develop more effective approaches for cancer treatment as the global cancer morbidity rises. Photodynamic therapy (PDT), as a non-invasive and potentially effective alternative to conventional approaches, has attracted much attention over the past few decades.…”

Section: Introductionmentioning

confidence: 99%