Syntheses and spectral properties of O,O-disubstituted S-(5,6-dihydro-1,4-dithiine-2,3-dicarboximidomethyl)thiophosphates

Absorption of exaprolol from the in-situ gastrointestinal tract of rats and dogs

“…Exaprolol, 1-(2-cyclohexylphenoxy)-3-isopropylamino-2-propanol (Carissimi et al 1976;Jendrichovsky et al 1978), is another member of the series of P-adrenoceptor blocking drugs having a cycloalkyl group in the ortho-position of the aromatic ring. The cyclopentyl derivative has broad clinical application (Vierhapper et al 1980) and the cyclopropyl (Boissier et al 1971) and cyclohexyl (Tmovec et al 1982: Tomtikovh et a1 1984Hughes et al 1984) derivatives are being investigated.…”