Syntheses, crystal structures, hirshfeld surface analyses and electrochemical etoposide/camptotechin sensor applications of acetaldehyde oxime derivatives

Topkaya, Cansu Gökçe; Aslan, Sema; Hökelek, Tuncer; Göktürk, Tolga; Kıncal, Sultan; Altuntaş, Derya Bal; Güp, Ramazan

doi:10.1016/j.molstruc.2022.133339

Cited by 9 publications

(2 citation statements)

References 47 publications

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“…[22] The binding capacity of the drug with the protein determines its pharmacodynamic properties like distribution, retention, excretion, and dosage frequency. [23][24][25] A large binding constant lessens free drug concentration in plasma and thus therapeutic effects would enhance. Drug toxicity dwindled with decreasing frequent use and increasing the binding with albumin protein.…”

Section: Introductionmentioning

confidence: 99%

“…Disulfide bonds organize the BSA single chain into nine loops for binding, while hydrogen bonds can easily be disrupted under the influence of chemical denaturants [22] . The binding capacity of the drug with the protein determines its pharmacodynamic properties like distribution, retention, excretion, and dosage frequency [23–25] . A large binding constant lessens free drug concentration in plasma and thus therapeutic effects would enhance.…”

Section: Introductionmentioning

confidence: 99%

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Comprehensive Biological, Photodegradation, Density Functional Theory, and Docking Exploration of Zn(II) and Mn(II) complexes of Piroxicam

Maha,

Tajammal,

Samra

et al. 2023

ChemistrySelect

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The biological evaluation of coordination complexes is an active research area ascribed to structural modification and synergistic action due to metal ions. The mononuclear complexes of Zn(II) and Mn(II) piroxicam were evaluated for their encyclopedic biological activities, DFT, and docking exploration. Different antioxidant methods were used to assess their antioxidant potential. DNA cleavage and protein binding properties of the complexes were monitored through gel electrophoresis and UV‐visible spectrophotometry. The low IC50 value of both complexes implies more potency than the piroxicam. The percent cleavage and binding constant values indicated that the complexes bind with DNA and BSA more efficiently than the piroxicam. In SD rats, complexes were screened for analgesic, anti‐anxiety, anti‐inflammatory, and anti‐hyperglycemic effects. The complexes demonstrated statistically significant results for in‐vivo analysis. Photodegradation results of the metal complexes under UV lamp exhibited abrupt degradation than the piroxicam. Docking results also validate a better propensity of both complexes to bind with DNA and BSA. Hydrogen bonding and Van der Waals forces play a key role in stabilizing complexes in DNA and BSA binding pockets. These metal complexes have evident therapeutic potential more than piroxicam and could be promising drugs for relieving pain, anxiety, inflammation, and associated comorbidities with good pharmacodynamic properties.

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