Syntheses, equilibrium, and structural studies of copper(II) and nickel(II) complexes with a tripodal alanine-based ligand

Tuning the coordination properties of multi-histidine peptides by using a tripodal scaffold: solution chemical study and catechol oxidase mimicking

“…25 A tren-based, alanine-containing tripodal ligand (tris[(L)-alanyl-2-carboxamidoethyl]amine) forms highly stable, amide coordinated mono-and dinuclear complexes with copper(II). 26 Copper(II) complexes of some histidine-containing branched peptides have also been studied. 27,28 Surprisingly, oligonuclear complexes were not detected in spite of the high number of available donor sites.…”

“…Several tripodal peptides with different platforms have been designed as receptors of either organic molecules 16 or metal ions. [17][18][19][20][21][22][23][24][25][26][27][28][29] These ligands have several advantages in addition to the pre-organized structure and enhanced chelate effect. Using different amino acids, it is relatively easy to fine-tune the metal ion binding ability.…”

“…Only a few reports are available in the literature describing metal ion interactions with tripodal peptides, [17][18][19][20][21][22][23][24][25][26][27][28] most of them are related to sulphur-containing ligands. [17][18][19][20][21] A series of tricarboxylic acids have been used 22 …”

New peptide-type tripodal ligands and their metal complexes

“…As example for non-histidyl compounds, a tren-based alanine ligand has been synthesized by Mohamadou et al, and characterized in presence of Cu(II) and Ni(II) ions. Interestingly, formation of dinuclear copper(II) complexes has been detected at metal excess, which, beside UV-Vis and EPR analyses, was also confirmed by ESI-MS results [40].…”

Stability prediction of copper(II) complexes with peptides containing cysteinic disulfide bridge by models based on the connectivity index 3χv

“…This chemically poorly defined, but very important class of compounds encompasses chelates of biogenic amines, amino acids, oligopepties, and nucleotides as well as their mixed complexes [13][14][15][16].…”